Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 20,801–20,825 of 27,380 studies, newest first · page 833 of 1096.
May 2010 25
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2010-05-18
Recording care time in nursing homes: development and validation of the "RUD-FOCA" (Resource Utilization in Dementia-Formal Care)
51/100 ✓ Peer-reviewed Treatments International psychogeriatrics
Key finding: Overall time and the times for ADL care and supervision can be considered valid estimates. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-05-17
Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain
40/100 ✓ Peer-reviewed Risk factors Particle and fibre toxicology
Key finding: Our results indicate that different brain regions may be uniquely responsive to changes induced by exposure to DEE. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-17
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Proceedings of the National Academy of Sciences of the United States of America
Key finding: The epsilon4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for Alzheimer's disease (AD), but limited work has suggested that APOE genotype may modulate disease phenotype. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-17
Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
56/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of Aging
Key finding: High PiB binding was present in 33% of HC (49% in ApoE-epsilon4 carriers vs 21% in noncarriers) and increased with age, most strongly in epsilon4 carriers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-16
Plasma Abeta42 and Abeta40 as markers of cognitive change in follow-up: a prospective, longitudinal, population-based cohort study
52/100 ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry
Key finding: Low or decreasing plasma Aβ42 during the follow-up is associated with cognitive decline. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-05-14
Exploring the brain network: a review on resting-state fMRI functional connectivity
36/100 ✓ Peer-reviewed Brain scans and imaging European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Key finding: These studies have revealed interesting new findings about the functional connections of specific brain regions and local networks, as well as important new insights in the overall organization of functional communication in the brain network. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-05-14
Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium
40/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of aging
Key finding: LPS-treated ME7 animals showed heightened and prolonged transcription of inflammatory mediators in the central nervous system (CNS), compared with LPS-treated normal animals, despite having equivalent levels of circulating cytokines.
Full summary, score breakdown and related studies → Original source
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2010-05-14
Validity of the telephone interview for cognitive status (TICS) and modified TICS (TICSm) for mild cognitive imparment (MCI) and dementia screening
41/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of gerontology and geriatrics
Key finding: TICS and TICSm were administered to 70 cognitively normal (CN), 75 MCI, and 85 dementia subjects, with mini-mental state examination (MMSE) and other cognitive and functional measures. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-14
Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance
44/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Although one possible explanation is through an effect on beta-amyloid (Abeta) metabolism, its effect remains to be elucidated. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-12
Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline
63/100 ✓ Peer-reviewed Genetics Neurology
Key finding: Longitudinal fMRI provides a reliable indicator of brain activation over time, and may prove useful in identifying functional brain changes associated with cognitive decline on the trajectory toward clinical Alzheimer disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-11
Physical activity and functional limitations in older adults: a systematic review related to Canada's Physical Activity Guidelines
57/100 ✓ Peer-reviewed Prevention and risk The international journal of behavioral nutrition and physical activity
Key finding: Sixty-six studies met inclusion criteria for the relationship between physical activity and functional independence, and 34 were included with a cognitive function outcome. +3 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-07
Glycemia and levels of cerebrospinal fluid amyloid and tau in patients attending a memory clinic
52/100 ✓ Peer-reviewed Tau biomarkers Journal of the American Geriatrics Society
Key finding: In regression analyses across the whole study sample adjusted for age, sex, and diagnostic group, there was no relationship between HbA1c or fasting glucose and CSF tau, p-tau 182, or Abeta42 levels. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-07
Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study
51/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: Both a genotype test, using logistic regression, and an allele test provided consistent evidence that variants in the RELN gene are associated with neuropathology in the context of cognitive health. +2 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-06
Cognition, language, and clinical pathological features of non-Alzheimer's dementias: an overview
37/100 ✓ Peer-reviewed Digital health tools Journal of communication disorders
Key finding: The value and durability of this potential contribution, however, demands an improved discipline-wide knowledge base about the unique features associated with different dementia variants.
Full summary, score breakdown and related studies → Original source
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2010-05-06
Genome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebellar ataxia pathogenesis
40/100 ✓ Peer-reviewed Genetics Neurobiology of aging
Key finding: Neurodegenerative pathologies associated with aging exhibit clinical and morphological features that are relatively specific to humans. +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-05-05
Dual-task performances can be improved in patients with dementia: a randomized controlled trial
69/100 ✓ Peer-reviewed Prevention and risk Neurology
Key finding: Classification of evidence This study provides Class II evidence that specific dual-task training improves dual-task performance during walking under complex S3 conditions in geriatric patients with mild to moderate dementia. +2 more findings
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2010-05-02
Why pleiotropic interventions are needed for Alzheimer's disease
40/100 ✓ Peer-reviewed Treatments Molecular neurobiology
Key finding: This approach would not only focus on blocking early events in pathogenesis, but also adequately correct for loss of synapses, substrates for neuroprotective pathways (e.g., docosahexaenoic acid), defects in energy metabolism, and adverse consequences of inappropriate compensatory responses (aberrant sprouting). +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-02
Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer's disease
44/100 ✓ Peer-reviewed Risk factors Ageing research reviews
Key finding: A growing body of epidemiological evidence suggested that metabolic syndrome (MetS) and Mets components (impaired glucose tolerance, abdominal or central obesity, hypertension, hypertriglyceridemia, and reduced high-density lipoprotein cholesterol) may be important in the development of age-related cognitive decline (ARCD), mild cognitive impairment (MCI), vascular dementia, and Alzheimer's disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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2010-05-01
Deaths: final data for 2007
48/100 ✓ Peer-reviewed Disparities National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System
Key finding: Mortality patterns in 2007, such as the decline in the age-adjusted death rate to a record historical low, were generally consistent with long-term trends.
Full summary, score breakdown and related studies → Original source
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2010-05-01
The assessment of frailty in older adults
36/100 ✓ Peer-reviewed Prevention trials Clinics in geriatric medicine
Key finding: Expanded models of physical frailty (models that included clusters other than the original 5 items such as dementia) increased considerably the predicting capacity of poor clinical outcomes when compared with the predictive capacity of the physical phenotype.
Full summary, score breakdown and related studies → Original source
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2010-05-01
Alzheimer's disease: strategies for disease modification
36/100 ✓ Peer-reviewed Treatments Nature reviews. Drug discovery
Key finding: Current drugs improve symptoms, but do not have profound disease-modifying effects. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative
40/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: We will modernize and expand the MRI protocol for all newly enrolled ADNI-GO and ADNI-2 subjects. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
55/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Major goals include (1) blood sample processing, genotyping, and dissemination, (2) genome-wide association studies (GWAS) of longitudinal phenotypic data, and (3) providing a central resource, point of contact and planning group for genetics within the Alzheimer's Disease Neuroimaging Initiative. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans
64/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Furthermore, these data have facilitated the development of novel clinical trial designs. +4 more findings
Full summary, score breakdown and related studies → Original source
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2010-05-01
Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease
40/100 ✓ Peer-reviewed Biomarkers Glia
Key finding: We found reduction of surface and volume of GFAP profiles from early ages (6 months; 43.84 and 52.76%, respectively), persisting at 12 (40.73 and 45.39%) and 18 months (64.80 and 71.95%) in the dentate gyrus (DG) of 3xTg-AD, whereas in CA1 it appears at 18 months (29.42 and 32.74%). +2 more findings
Full summary, score breakdown and related studies → Original source
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