Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 14,576–14,600 of 27,380 studies, newest first · page 584 of 1096.
November 2017 25
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2017-11-24
Centiloid method evaluation for amyloid PET of subcortical vascular dementia
39/100 ✓ Peer-reviewed Brain scans and imaging Scientific reports
Key finding: In 57 [C-11] Pittsburgh compound B (PiB) positive (+) AD and 23 PiB (+) SVaD patients, we assessed standardized PiB uptake and Centiloid scores in disease-specific cortical regions, with several reference regions: cerebellar gray (CG), whole cerebellum (WC), WC with brainstem (WC + B), pons, and white matter (WM). +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-24
Forging a Frailty-Ready Healthcare System to Meet Population Ageing
41/100 ✓ Peer-reviewed End-of-life care International journal of environmental research and public health
Key finding: This paper will describe initiatives within the RHS frameworks of the National Health Group (NHG) and the Alexandra Health System (AHS) to forge a frailty-ready healthcare system across the spectrum, which includes the well healthy ("living well"), the well unhealthy ("living with illness"), the unwell unhealthy ("living with frailty"), and the end-of-life (EoL) ("dying well"). +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-24
Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease
46/100 ✓ Peer-reviewed Inflammation and the immune system Pharmacological research
Key finding: The exact pathophysiology of this disease remains incompletely understood and safe and effective therapies are required. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-24
Idiopathic REM sleep behaviour disorder and neurodegeneration - an update
52/100 ✓ Peer-reviewed Risk factors Nature reviews. Neurology
Key finding: Given the very high risk that patients with idiopathic RBD have of developing α-synucleinopathies, such as Parkinson disease (PD), PD dementia, dementia with Lewy bodies or multiple system atrophy, and the outstandingly high specificity and very long interval between the onset of idiopathic RBD and the clinical manifestations of α-synucleinopathies, the prodromal phase of this disorder represents a unique opportunity for potentially disease-modifying intervention. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-24
Validation of Noninvasive Tracer Kinetic Analysis of 18F-Florbetaben PET Using a Dual-Time-Window Acquisition Protocol
52/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: An acquisition protocol using time windows of 0-30 and 120-140 min with appropriate interpolation of the missing time points provided the best compromise between patient comfort and quantification accuracy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-23
Racial Differences in Caregiving: Variation by Relationship Type and Dementia Care Status
41/100 ✓ Peer-reviewed Disparities Journal of aging and health
Key finding: After covariate adjustment, there were few significant racial differences in caregiving strain, health, and service use. +4 more findings
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2017-11-23
Determinants of late-life depression in residents of long-term care facility
50/100 ✓ Peer-reviewed Risk factors Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Key finding: Depression symptoms were observed in 33.8% of LTCF residents. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-23
Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants
43/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: CSF Aβ1-42 was higher in the T2DM group than the nondiabetic group. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-22
Burden among Family Caregivers of Dementia in the Oldest-Old: An Exploratory Study
52/100 ✓ Peer-reviewed Caregiving Frontiers in medicine
Key finding: Oldest-old care recipients were more impaired in cognitive function and instrumental ADL; there was no difference in behavior and basic ADL. +4 more findings
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2017-11-22
The Role of Glucagon-Like Peptide 1 (GLP1) in Type 3 Diabetes: GLP-1 Controls Insulin Resistance, Neuroinflammation and Neurogenesis in the Brain
41/100 ✓ Peer-reviewed Drug development International journal of molecular sciences
Key finding: Several studies have demonstrated that GLP-1 alleviates learning and memory dysfunction by enhancing the regulation of glucose in the AD brain.
Full summary, score breakdown and related studies → Original source
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2017-11-22
Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimer's disease
38/100 ✓ Peer-reviewed Drug development Biochemical and biophysical research communications
Key finding: We have previously shown that the long-lasting GLP-1 receptor (GLP-1R) agonist lixisenatide plays an important role in memory formation, synaptic plasticity and cell proliferation of rats. +2 more findings
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2017-11-22
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder
45/100 ✓ Peer-reviewed Hippocampus size on brain scans Progress in neuro-psychopharmacology & biological psychiatry
Key finding: Analysis revealed 30 genes differentially expressed in MDD compared to controls (FDR<0.05). +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-21
Computerized cognitive stimulation and engagement programs in older adults with mild cognitive impairment: comparing feasibility, acceptability, and cognitive and psychosocial effects
62/100 ✓ Peer-reviewed Digital health tools Clinical interventions in aging
Key finding: Both interventions were highly feasible and acceptable and allowed improvement in different aspects of cognitive and psychosocial functioning in MCI subjects. +3 more findings
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2017-11-21
Body mass index and risk of dementia: Analysis of individual-level data from 1.3 million individuals
73/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The association between BMI and dementia is likely to be attributable to two different processes: a harmful effect of higher BMI, which is observable in long follow-up, and a reverse-causation effect that makes a higher BMI to appear protective when the follow-up is short.
Full summary, score breakdown and related studies → Original source
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2017-11-20
Decreased Complexity in Alzheimer's Disease: Resting-State fMRI Evidence of Brain Entropy Mapping
43/100 ✓ Peer-reviewed Cognitive tests and assessment Frontiers in aging neuroscience
Key finding: Resting-state functional magnetic resonance imaging (rs-fMRI) has been introduced as an alternative approach to assessing brain functional abnormalities in AD patients. +3 more findings
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2017-11-17
Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells
41/100 ✓ Peer-reviewed Drug development Scientific Reports
Key finding: Growing evidence suggests that agonists of glucagon-like peptide (GLP-1) receptor exert neuroprotective and neurorestorative effects across a range of experimental models of neuronal degeneration, and, recently, a pilot clinical trial of Liraglutide in Alzheimer’s disease patients showed improvements in cerebral glucose consumption that signifies disease progression.
Full summary, score breakdown and related studies → Original source
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2017-11-17
Neurotrophic and Neuroregenerative Effects of GH/IGF1
41/100 ✓ Peer-reviewed Costs and economics International journal of molecular sciences
Key finding: Although strong findings have shown the positive effects of GH/IGF-1 administration on neuroregeneration in animal models, a very limited number of clinical studies have been conducted in humans. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-17
Adherence to Mediterranean diet and subjective cognitive function in men
64/100 ✓ Peer-reviewed Prevention trials European journal of epidemiology
Key finding: In a multivariate model, compared with men having a MD score in the lowest quintile, those in the highest quintile had a 36% lower odds of a poor SCF score (odds ratio 0.64, 95% CI 0.55-0.75; P, trend < 0.001) and a 24% lower odds of a moderate SCF score (OR 0.76, 95% CI 0.70-0.83; P, trend < 0.001). +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-11-17
Bile acid quantification of 20 plasma metabolites identifies lithocholic acid as a putative biomarker in Alzheimer's disease
50/100 ✓ Peer-reviewed Mild cognitive impairment Metabolomics : Official journal of the Metabolomic Society
Key finding: Levels of lithocholic acid were significantly enhanced in plasma of AD patients (50 ± 6 nM, p = 0.004) compared to healthy controls (32 ± 3 nM). +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-16
Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers
48/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging
Key finding: Decreased CSF amyloid β42 significantly correlated with increased theta and delta GFP, whereas increased p- and t-tau with decreased alpha and beta GFP. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-16
An overview of systematic reviews of pharmacological and non-pharmacological interventions for the treatment of behavioral and psychological symptoms of dementia
66/100 ✓ Peer-reviewed Treatments International psychogeriatrics
Key finding: ABSTRACTBackground:This systematic overview reports findings from systematic reviews of randomized controlled trials of pharmacological and non-pharmacological interventions for behavioural and psychological symptoms of dementia (BPSD). +2 more findings
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2017-11-16
Hospice Care for Patients With Dementia in the United States: A Longitudinal Cohort Study
69/100 ✓ Peer-reviewed End-of-life care Journal of the American Medical Directors Association
Key finding: Patients with dementia are significantly more likely to be disenrolled from hospice following a long enrollment period compared with patients without dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-15
DHA supplementation improves cognitive function via enhancing Aβ-mediated autophagy in Chinese elderly with mild cognitive impairment: a randomised placebo-controlled trial
76/100 ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry
Key finding: Daily oral DHA supplementation (2 g/day) for 24 months may improve cognitive function and change blood biomarker-related Aβ-mediated autophagy in people with MCI. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-11-15
Cerebral vasoreactivity and intima-media thickness in Down syndrome: A case-control study
42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of the neurological sciences
Key finding: In Alzheimer Disease, impaired vasoreactivity has been reported as the results of vascular amyloid deposition. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-11-14
Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms
38/100 ✓ Peer-reviewed Disease mechanisms Expert review of neurotherapeutics
Key finding: Our studies support the hypothesis that intestinal microbiota may help protect against AD, in part, by supporting the generation of select SCFAs, which interfere with the formation of toxic soluble Aβ aggregates.
Full summary, score breakdown and related studies → Original source
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