Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,801–15,825 of 27,380 studies, newest first · page 633 of 1096.
September 2016 25
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2016-09-09
Strategy-Based Cognitive Training for Improving Executive Functions in Older Adults: a Systematic Review
74/100 ✓ Peer-reviewed Prevention trials Neuropsychology review
Key finding: Despite heterogeneous study designs and SCT programs, 11/13 trials reported significant EF improvements, generally of moderate effect size (Hedges' g > 0.3). +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-09-09
Age-Related Sensory Impairments and Risk of Cognitive Impairment
65/100 ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society
Key finding: The relationship between sensory impairment and cognitive impairment was not unique to one sensory system, suggesting that sensorineural health may be a marker of brain aging. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-09-08
Cognitive change is more positively associated with an active lifestyle than with training interventions in older adults at risk of dementia: a controlled interventional clinical trial
45/100 ✓ Peer-reviewed Prevention trials BMC psychiatry
Key finding: The associations of an active lifestyle with cognitive change over time in a dementia risk group were stronger than the effects of short-term, specific training interventions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-08
Repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training is a safe and effective modality for the treatment of Alzheimer's disease: clinical experience
43/100 ✓ Peer-reviewed Prevention trials Journal of neural transmission (Vienna, Austria : 1996)
Key finding: The previous clinical trials showed that combinations of rTMS and cognitive training (rTMS-COG), as provided by the NeuroAD medical device system, offer a novel, safe, and effective method improving mild-to-moderate AD patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-09-08
Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students
51/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurochemistry
Key finding: In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases.
Full summary, score breakdown and related studies → Original source
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2016-09-07
Florbetapir-PET to diagnose cerebral amyloid angiopathy: A prospective study
41/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: The CAA and HTN-ICH groups had similar age (66.9 vs 67.1), sex, and leukoaraiosis volumes (31 vs 30 mL, all p > 0.8). +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-07
Rates of Recovery to Pre-Fracture Function in Older Persons with Hip Fracture: an Observational Study
47/100 ✓ Peer-reviewed Costs and economics Journal of general internal medicine
Key finding: Recovery rates are low, even among those with higher levels of pre-fracture functional status, and are worse for patients who are older, cognitively impaired, and who have multiple comorbidities. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-06
Neurological Disease as a Failure of Brain-Immune Crosstalk: The Multiple Faces of Neuroinflammation
42/100 ✓ Peer-reviewed Inflammation and the immune system Trends in immunology
Key finding: It is now recognized that neuroinflammation in chronic neurodegenerative conditions, including Alzheimer's disease (AD) and age-related dementia, is distinct from the inflammation that accompanies relapsing-remitting multiple sclerosis (RRMS), and its experimental animal model, experimental autoimmune encephalomyelitis (EAE). +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-06
Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease
63/100 ✓ Peer-reviewed Lewy body dementia FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Key finding: Synaptic dysfunction occurs early in senile dementias, presumably as a result of decreased levels of functional synaptic proteins as found in autopsied brains of patients with Alzheimer's disease (AD) or frontotemporal dementia (FTD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-04
Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses
71/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Dementia is a heterogeneous neurodegenerative disease, whose etiology results from a complex interplay between environmental and genetic factors. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-04
Systematic review of dementia prevalence and incidence in United States race/ethnic populations
75/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Dementia prevalence rates reported for age 65+ years from a low of 6.3% in Japanese Americans, 12.9% in Caribbean Hispanic Americans, 12.2% in Guamanian Chamorro and ranged widely in African Americans from 7.2% to 20.9%. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-09-02
Effect of a Home‐Based Palliative Care Program on Healthcare Use and Costs
52/100 ✓ Peer-reviewed Health systems and care delivery Journal of the American Geriatrics Society
Key finding: Intervention participants in all four disease groups had less hospital use and lower hospital costs nonintervention participants, which drove lower overall healthcare costs. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-02
Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression
44/100 ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica communications
Key finding: TREM2 encodes a cell surface receptor expressed on microglia and related cells, and the R47H variant associated with AD appears to affect the ability of TREM2 to bind extracellular ligands. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-09 month only
Sleep Disturbances in Frontotemporal Dementia
38/100 ✓ Peer-reviewed Risk factors Current neurology and neuroscience reports
Key finding: Insomnia and excessive daytime sleepiness commonly occur in patients with FTD and significantly contribute to caregiver burden and burnout.
Full summary, score breakdown and related studies → Original source
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2016-09-01
Regular Benzodiazepine and Z-Substance Use and Risk of Dementia: An Analysis of German Claims Data
50/100 ✓ Peer-reviewed Digital health tools Journal of Alzheimer's disease : JAD
Key finding: The restricted use of BDZRs may contribute to dementia prevention in the elderly. +3 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-01
Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents
36/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD
Key finding: Exposure to fine particulate matter (PM2.5) and ozone (O3) above US EPA standards is associated with Alzheimer's disease (AD) risk, while Mn toxicity induces parkinsonism. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-01
Pesticide exposure and risk of Alzheimer's disease: a systematic review and meta-analysis
72/100 ✓ Peer-reviewed Risk factors Scientific reports
Key finding: Evidence suggests that lifelong cumulative exposure to pesticides may generate lasting toxic effects on the central nervous system and contribute to the development of Alzheimer's disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-01
Effects of air pollution on human health and practical measures for prevention in Iran
40/100 ✓ Peer-reviewed Risk factors Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
Key finding: Several reports have revealed the direct association between exposure to the poor air quality and increasing rate of morbidity and mortality mostly due to cardiovascular and respiratory diseases.
Full summary, score breakdown and related studies → Original source
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2016-09-01
Age-related hearing loss: prevention of threshold declines, cell loss and apoptosis in spiral ganglion neurons
40/100 ✓ Peer-reviewed Risk factors Aging
Key finding: We found that hearing thresholds and suprathreshold responses significantly improved in the aldosterone-treated mice compared to the non-treatment group. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-01
Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging
60/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: These measurements were compared with each other and used as reference standards for defining an appropriate 20-min window for the SUV ratio (SUVR). +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-09-01
Conceptualization of an evidence-based smartphone innovation for caregivers and persons living with dementia
40/100 ✓ Peer-reviewed Cognitive tests and assessment Technology and health care : official journal of the European Society for Engineering and Medicine
Key finding: A review of the existing literature shows that much of these innovations are focused on the care of patients affiliated with dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-01
Youthful Brains in Older Adults: Preserved Neuroanatomy in the Default Mode and Salience Networks Contributes to Youthful Memory in Superaging
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: We defined superagers (60-80 years old) based on their performance compared to young adults (18-32 years old) on the California Verbal Learning Test Long Delay Free Recall test. +4 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-01
Revisiting DLB Diagnosis: A Consideration of Prodromal DLB and of the Diagnostic Overlap With Alzheimer Disease
36/100 ✓ Peer-reviewed Clinical safety Journal of geriatric psychiatry and neurology
Key finding: Efforts to clinically diagnose cases having dementia with Lewy bodies (DLB) identify those with a characteristic clinical syndrome (probable DLB) at the expense of missing an equal, if not greater, number of cases who have atypical presentations thought to be associated with coexisting Alzheimer pathologies. +1 more finding
Full summary, score breakdown and related studies → Original source
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2016-09-01
Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability
40/100 ✓ Peer-reviewed Disease mechanisms Stem cell reports
Key finding: Frontotemporal dementia (FTD) and other tauopathies characterized by focal brain neurodegeneration and pathological accumulation of proteins are commonly associated with tau mutations. +2 more findings
Full summary, score breakdown and related studies → Original source
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2016-09-01
Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence
36/100 ✓ Peer-reviewed Disease mechanisms CNS drugs
Key finding: Mounting evidence suggests that APOE ε4 contributes to AD pathogenesis through multiple pathways including facilitated amyloid-β deposition, increased tangle formation, synaptic dysfunction, exacerbated neuroinflammation, and cerebrovascular defects.
Full summary, score breakdown and related studies → Original source
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