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66/100

✓ Peer-reviewed alzhub usefulness score 66 out of 100. Brain scans and imaging

Topic: Amyloid, tau and blood-test diagnosis

However, the extent to which increasing age, Aβ, and ε4 are associated with memory decline remains unclear, and the age at which memory decline begins for Aβ-positive ε4 carriers and noncarriers has not been determined. Results Of the 447 participants, 203 (45.4%) were men and 244 (54.6%) were women; mean (SD) age was 72.5 (6.6) years. Memory decline diverged significantly from Aβ-negative ɛ4 noncarriers at an earlier age in Aβ-positive ɛ4 carriers (64.5 years) than in Aβ-positive ɛ4 noncarriers (76.5 years), such that by 85 years of age, Aβ-positive ε4 carriers performed approximately 1.5 SD units worse on the episodic memory composite than Aβ-negative ε4 noncarriers and approximately 0.8 SD units worse than Aβ-positive ε4 noncarriers. Conclusions and relevance Prior work has shown that Aβ and ε4 combine to influence memory decline in nondemented older adults. Results of this study indicate that increasing age may further exacerbate these effects. The estimates provided may be used to determine the risk of memory decline associated with Aβ and ε4 at each age.

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APA 7th

Lim, Y. Y., Kalinowski, P., Pietrzak, R. H., Laws, S. M., Burnham, S. C., Ames, D., et al. (2018). Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease. JAMA neurology. https://doi.org/10.1001/jamaneurol.2017.4325

Vancouver

Lim YY, Kalinowski P, Pietrzak RH, Laws SM, Burnham SC, Ames D, et al. Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease. JAMA neurology. 2018. doi:10.1001/jamaneurol.2017.4325. PMID: 29356823.

BibTeX

@article{lim2018-29356823,
  author  = {Lim, Y. Y. and Kalinowski, P. and Pietrzak, R. H. and Laws, S. M. and Burnham, S. C. and Ames, D. and Villemagne, V. L. and Fowler, C. J. and others},
  title   = {{Association of β-Amyloid and Apolipoprotein E ε4 With Memory Decline in Preclinical Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2017.4325},
  pmid    = {29356823},
  url     = {https://doi.org/10.1001/jamaneurol.2017.4325}
}

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Key findings

However, the extent to which increasing age, Aβ, and ε4 are associated with memory decline remains unclear, and the age at which memory decline begins for Aβ-positive ε4 carriers and noncarriers has not been determined.
Results Of the 447 participants, 203 (45.4%) were men and 244 (54.6%) were women; mean (SD) age was 72.5 (6.6) years.
Memory decline diverged significantly from Aβ-negative ɛ4 noncarriers at an earlier age in Aβ-positive ɛ4 carriers (64.5 years) than in Aβ-positive ɛ4 noncarriers (76.5 years), such that by 85 years of age, Aβ-positive ε4 carriers performed approximately 1.5 SD units worse on the episodic memory composite than Aβ-negative ε4 noncarriers and approximately 0.8 SD units worse than Aβ-positive ε4 noncarriers.
Conclusions and relevance Prior work has shown that Aβ and ε4 combine to influence memory decline in nondemented older adults.
Results of this study indicate that increasing age may further exacerbate these effects.

Why it matters

Among 447 participants, memory decline began at an earlier age in amyloid-positive apolipoprotein E ε4 carriers (64.5 years) than in amyloid-positive noncarriers (76.5 years), with larger declines by age 85. This describes how age, amyloid and ε4 combine to affect memory decline and does not provide a treatment or cure.

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Study details

Study designlongitudinal study
Participants1,583
Effect size45.4%; 54.6%; 47.1%
Evidence strengthModerate

How this study scored 66/100

Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	3 / 4	1,583 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 83 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	8.3 citations a year over 10 year(s) since 2018
Impact for its field and year	4 / 6	Cited 8.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 7 other studies in this library
Still being cited	1 / 4	Cited 13 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Paul T. Maruff: h-index 102 (OpenAlex, whole career)
Institution's track record	2 / 3	Yale University: institution h-index 1,927 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 12 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 29356823)
Free to read	0 / 2	Behind a paywall — scores zero
Total	66 / 100	—

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