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TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease
Zhang Y, Feng S, Nie K, Li Y, Gao Y, Gan R, Wang L, Li B et al.. Biochemical and biophysical research communications, 2018-04-04
Topic: Brain proteins, microglia and lab models
Neuroinflammation and overactivated microglia underlies the pathogenesis of Parkinson's disease (PD). Furthermore, microglia could polarize into classic inflammatory M1 and immunosuppressive M2 phenotype. Thus, inhibiting the overactivated inflammatory M1 microglia by promoting the transformation of microglia to the protective M2 phenotype provides potential therapy for PD, but the mechanism that modulates microglia polarization remains unknown.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhang, Y., Feng, S., Nie, K., Li, Y., Gao, Y., Gan, R., et al. (2018). TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. https://doi.org/10.1016/j.bbrc.2018.03.226
Vancouver
Zhang Y, Feng S, Nie K, Li Y, Gao Y, Gan R, et al. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. 2018. doi:10.1016/j.bbrc.2018.03.226. PMID: 29621548.
BibTeX
@article{zhang2018-29621548,
author = {Zhang, Y. and Feng, S. and Nie, K. and Li, Y. and Gao, Y. and Gan, R. and Wang, L. and Li, B. and others},
title = {{TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease}},
journal = {Biochemical and biophysical research communications},
year = {2018},
doi = {10.1016/j.bbrc.2018.03.226},
pmid = {29621548},
url = {https://doi.org/10.1016/j.bbrc.2018.03.226}
}
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Key findings
- Furthermore, microglia could polarize into classic inflammatory M1 and immunosuppressive M2 phenotype.
- Thus, inhibiting the overactivated inflammatory M1 microglia by promoting the transformation of microglia to the protective M2 phenotype provides potential therapy for PD, but the mechanism that modulates microglia polarization remains unknown.
- Triggering receptor expressed on myeloid cells-2 (TREM2) is a recently identified immune receptor expressed by the microglia in the brain.
- Emerging evidence indicates that TREM2 enhances the phagocytosis function of microglia and suppress inflammation.
Why it matters
This study discusses TREM2 as a way microglia may shift between inflammatory and protective states in Parkinson's disease. It concerns Parkinson's disease, not Alzheimer's disease treatment or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biochemical and biophysical research communications) |
| Journal's citation record | 3 / 4 | Biochemical and Biophysical Research Communications: journal h-index 393 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 152 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.2 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 3 / 6 | Cited 4.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 2 / 4 | Cited 49 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Yuhu Zhang: h-index 34 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Southern Medical University: institution h-index 497 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29621548) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
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