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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 14,126–14,150 of 27,380 studies, newest first · page 566 of 1096.

April 2018 3

  1. 2018-04-01

    Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections-a Nationwide, Population-Based Cohort Study in Taiwan

    ✓ Peer-reviewed Prevention and risk Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    Key finding: This analysis revealed an adjusted hazard ratio of 2.564 (95% CI: 2.351-2.795, P < 0.001) for the development of dementia in the HSV-infected cohort relative to the non-HSV cohort. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2018-04-01

    Glial alterations in human prion diseases: A correlative study of astroglia, reactive microglia, protein deposition, and neuropathological lesions

    ✓ Peer-reviewed Biomarkers Medicine

    Key finding: Proteinopathies such as Alzheimer, Parkinson, and Huntington diseases, where aberrant proteins spread throughout the brain during disease progression, may share a molecular basis and mechanisms of propagation. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2018-04 month only

    NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

    ✓ Peer-reviewed Getting a diagnosis Alzheimer's & Dementia

    Key finding: Introduced the A (amyloid)/T (tau)/N (neurodegeneration) biomarker classification framework +3 more findings

    Full summary, score breakdown and related studies → Original source

March 2018 22

  1. 2018-03-31

    Mediterranean Diet and Health Outcomes in the SUN Cohort

    ✓ Peer-reviewed Prevention trials Nutrients

    Key finding: After reviewing 21 publications from the SUN cohort on the effects of the MedDiet, we conclude that this cohort has provided good evidence that a high MedDiet adherence is associated with a reduced incidence of all-cause mortality, fatal and non-fatal major cardiovascular disease (CVD), type 2 diabetes, weight gain, metabolic syndrome, depression, cognitive decline, and nephrolithiasis. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2018-03-30

    Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

    ✓ Peer-reviewed Genetics The Journal of clinical investigation

    Key finding: There is compelling evidence that apoE influences Alzheimer disease (AD) in large part by affecting amyloid β (Aβ) aggregation and clearance; however, the molecular mechanism underlying these findings remains largely unknown. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2018-03-29

    Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice

    ✓ Peer-reviewed Drug development Brain, behavior, and immunity

    Key finding: Cognitive dysfunction and neuroinflammation are typical in Alzheimer's disease (AD), but are also associated with normal aging, albeit less severely. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2018-03-29

    TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function

    ✓ Peer-reviewed TREM2 and immune genetics The Journal of biological chemistry

    Key finding: The rare variant R47H TREM2 is associated with an increased risk for Alzheimer's disease, supporting the hypothesis that TREM2 loss of function may exacerbate disease progression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2018-03-29

    Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

    ✓ Peer-reviewed TREM2 and immune genetics Stem cell reports

    Key finding: We describe a robust method for the derivation of human microglia from stem cells, which are phenotypically and functionally comparable with primary microglia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2018-03-28

    Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: The ability of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers (amyloid β peptide 1-42, total tau, and phosphorylated tau) to discriminate AD from related disorders is limited. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2018-03-28

    Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Genetic risk factors of AD dementia demonstrate effects related to Aβ, as well as synergistic interactions with Aβ. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2018-03-27

    Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization

    ✓ Peer-reviewed Treatments Journal of Nanobiotechnology

    Key finding: The production parameters were optimized by design of experiments. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2018-03-27

    Virtual reality-based cognitive-motor training for middle-aged adults at high Alzheimer's disease risk: A randomized controlled trial

    ✓ Peer-reviewed Prevention trials Alzheimer's & dementia (New York, N. Y.)

    Key finding: Current pharmacologic therapies are for symptomatic AD patients, whereas nonpharmacologic training is administrable before symptom onset.

    Full summary, score breakdown and related studies → Original source

  10. 2018-03-27

    Cellular players that shape evolving pathology and neurodegeneration following traumatic brain injury

    ✓ Peer-reviewed TREM2 and immune genetics Brain, behavior, and immunity

    Key finding: How the inflammatory cascade resulting from mechanical stress, axonal shearing and the loss of neurons and glia following initial impact in TBI, contributes to the development of AD-like disease is unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2018-03-27

    Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

    Key finding: TREM2 is an innate immune receptor specifically expressed in microglia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2018-03-27

    Improving Recovery and Outcomes Every Day after the ICU (IMPROVE): study protocol for a randomized controlled trial

    ✓ Peer-reviewed Treatments Trials

    Key finding: This study is the first clinical trial to examine the efficacy of combined physical and cognitive exercise on cognitive function in older ICU survivors with delirium.

    Full summary, score breakdown and related studies → Original source

  13. 2018-03-26

    Classification of Alzheimer's Disease Based on Eight-Layer Convolutional Neural Network with Leaky Rectified Linear Unit and Max Pooling

    ✓ Peer-reviewed Digital health tools Journal of medical systems

    Key finding: The numerical experiments demonstrated that leaky ReLU and max pooling gave the greatest result in terms of performance. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2018-03-26

    Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of age

    ✓ Peer-reviewed Risk factors Environmental research

    Key finding: Exposures to fine particulate matter (PM 2.5 ) and ozone (O 3 ) above USEPA standards are associated with Alzheimer's disease (AD) risk. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2018-03-26

    Increased expression of TREM2 in peripheral cells from mild cognitive impairment patients who progress into Alzheimer's disease

    ✓ Peer-reviewed TREM2 and immune genetics European journal of neurology

    Key finding: Neuroinflammation plays a role in the aetiopathogenesis of Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2018-03-26

    Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model

    ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology

    Key finding: Eight candidate predictors entered the prediction model: bulbar versus non-bulbar onset (univariable hazard ratio [HR] 1·71, 95% CI 1·63-1·79), age at onset (1·03, 1·03-1·03), definite versus probable or possible ALS (1·47, 1·39-1·55), diagnostic delay (0·52, 0·51-0·53), forced vital capacity (HR 0·99, 0·99-0·99), progression rate (6·33, 5·92-6·76), frontotemporal dementia (1·34, 1·20-1·50), and presence of a C9orf72 repeat expansion (1·45, 1·31-1·61), all p<0·0001.

    Full summary, score breakdown and related studies → Original source

  17. 2018-03-23

    Protein aggregates and proteostasis in aging: Amylin and β-cell function

    ✓ Peer-reviewed Disease mechanisms Mechanisms of ageing and development

    Key finding: A decline of protein degradation during aging results in the formation of oxidatively damaged and aggregated proteins finally resulting in failure of cellular functionality.

    Full summary, score breakdown and related studies → Original source

  18. 2018-03-23

    Memory decline accompanies subthreshold amyloid accumulation

    ✓ Peer-reviewed Hippocampus size on brain scans Neurology

    Key finding: Memory decline accompanies Aβ accumulation in otherwise healthy, Aβ-negative older adults. +2 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2018-03-21

    An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

    ✓ Peer-reviewed Inflammation and the immune system Frontiers in cellular neuroscience

    Key finding: Unlike a normally beneficial acute inflammatory response, chronic inflammation can lead to tissue damage and ultimately its destruction, and often results from an inappropriate immune response. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2018-03-20

    Pin1 mediates Aβ42-induced dendritic spine loss

    ✓ Peer-reviewed Disease mechanisms Science signaling

    Key finding: Studies suggest that dendritic spine loss is induced by soluble, multimeric amyloid-β (Aβ42), which, through postsynaptic signaling, activates the protein phosphatase calcineurin.

    Full summary, score breakdown and related studies → Original source

  21. 2018-03-20

    Joggin' the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits

    ✓ Peer-reviewed Prevention trials Neuroscience and biobehavioral reviews

    Key finding: Studies regarding exercise and cardiovascular fitness, angiogenesis, neuroinflammation in relation to IGF-1 signalling, regulation of neurotrophins, neurogenesis and plasticity, cognitive training, are briefly described. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2018-03-20

    Aerobic glycolysis and tau deposition in preclinical Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Neurobiology of aging

    Key finding: Our findings demonstrate that in individuals with amyloid burden, lower AG is associated with higher tau deposition. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →