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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 7,851–7,875 of 27,380 studies, newest first · page 315 of 1096.

March 2023 25

  1. 2023-03-17

    NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro

    ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry

    Key finding: Alzheimer's disease (AD) is associated with the cerebral deposition of Amyloid-β (Aβ) peptide, which leads to NLRP3 inflammasome activation and subsequent release of interleukin-1β (IL-1β) and interleukin-18 (IL-18). +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2023-03-17

    The clinical application of optimized AT(N) classification in Alzheimer's clinical syndrome (ACS) and non-ACS conditions

    ✓ Peer-reviewed Biomarkers Neurobiology of aging

    Key finding: The concordance of two A-markers (i.e., Aβ42 alone and the Aβ42/Aβ40 ratio) was not significantly different between the ACS (87.4%) and non-ACS (74.1%) groups. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2023-03-17

    Association of biological sex with clinical outcomes and biomarkers of Alzheimer's disease in adults with Down syndrome

    ✓ Peer-reviewed Biomarkers Brain communications

    Key finding: We used within-group locally estimated scatterplot smoothing models to compare the trajectory of biomarker changes with age in females versus males, as well as by apolipoprotein ɛ4 carriership. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2023-03-16

    Alzheimer's Disease and Alzheimer's Disease-Related Dementias in African Americans: Focus on Caregivers

    ✓ Peer-reviewed Disparities Healthcare (Basel, Switzerland)

    Key finding: Histopathological, morphological, and cellular studies revealed how multiple cellular changes are implicated in AD and ADRD, including synaptic damage, inflammatory responses, hormonal imbalance, mitochondrial abnormalities, and neuronal loss, in addition to the accumulation of amyloid beta and phosphorylated tau in the brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2023-03-16

    Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

    ✓ Peer-reviewed Vascular contributions Molecular neurodegeneration

    Key finding: Reducing the levels of APOE4 in astrocytes shifted the deposition of fibrillar Aβ from the brain parenchyma to the cerebrovasculature. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2023-03-16

    Ubiquitin Is Not a Blood Biomarker of an Early Cognitive Decline in the Polish Elderly

    ✓ Peer-reviewed Biomarkers Current issues in molecular biology

    Key finding: No significant disparities in plasma ubiquitin levels for various levels of cognitive functioning were identified. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2023-03-16

    Racial, ethnic and neighborhood socioeconomic differences in incidence of dementia: A regional retrospective cohort study

    ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

    Key finding: Increasing neighborhood disadvantage was associated with increased risk of EHR-documented dementia diagnosis or dementia-related death (most vs. least disadvantaged ADI quintile HR = 1.76, 95% confidence interval = 1.69-1.84) after adjusting for age and sex. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2023-03-16

    Readmission Rates and Episode Costs for Alzheimer Disease and Related Dementias Across Hospitals in a Statewide Collaborative

    ✓ Peer-reviewed Risk factors JAMA Network Open

    Key finding: The study included 722 911 hospitalization episodes, of which 66 676 were related to patients with ADRD (mean [SD] age, 83.4 [8.6] years; 42 439 [63.6%] female) and 656 235 were related to patients without ADRD (mean [SD] age, 66.0 [15.4] years; 351 246 [53.5%] female). +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2023-03-16

    Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies

    ✓ Peer-reviewed Brain tissue and pathology Science (New York, N.Y.)

    Key finding: TDP-43 mislocalization results in cryptic splicing and polyadenylation of pre-messenger RNAs (pre-mRNAs) encoding stathmin-2 (also known as SCG10), a protein that is required for axonal regeneration. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2023-03-16

    Plasma phospho-tau in Alzheimer's disease: towards diagnostic and therapeutic trial applications

    ✓ Peer-reviewed Caregiving Molecular neurodegeneration

    Key finding: One such promising biomarker is plasma phosphorylated tau (p-tau), which has demonstrated specificity to AD versus non-AD neurodegenerative diseases, and will be extremely important to inform on clinical diagnosis and eligibility for therapies that have recently been approved.

    Full summary, score breakdown and related studies → Original source

  11. 2023-03-15

    Effect of renal function on the diagnostic performance of plasma biomarkers for Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

    Key finding: Plasma Aβ42/40 was a robust biomarker for AD which was not affected by renal function. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2023-03-15

    Cognitive Health in Persons With Human Immunodeficiency Virus: The Impact of Early Treatment, Comorbidities, and Aging

    ✓ Peer-reviewed Risk factors The Journal of Infectious Diseases

    Key finding: As persons with HIV age, noninfectious comorbidities occur more frequently compared with persons without HIV. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2023-03-14

    2023 Alzheimer's disease facts and figures

    ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: This article describes the public health impact of Alzheimer's disease, including prevalence and incidence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2023-03-14

    Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study

    ✓ Peer-reviewed Prevention and risk BMC Medicine

    Key finding: Higher adherence to a MedDiet was associated with lower dementia risk, independent of genetic risk, underlining the importance of diet in dementia prevention interventions. +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2023-03-13

    Frequency and implications of coexistent manifestations of serious illness in older adults with dementia

    ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society

    Key finding: Most PWD (67%) met criteria for another manifestation of serious illness (24% advanced medical condition, 44% ADL impairment). +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2023-03-13

    Dementia Caregiving Experiences and Health Across Geographic Contexts by Race and Ethnicity

    ✓ Peer-reviewed Disparities The journals of gerontology. Series B, Psychological sciences and social sciences

    Key finding: Bivariate analyses indicated that nonmetro dementia caregivers were less racially/ethnically diverse (82.7% White, non-Hispanic) and more were spouses/partners (20.2%) than their metro counterparts (66.6% White, non-Hispanic; 13.3% spouses/partners). +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2023-03-13

    Characteristics and Predictors of Sleep Among Spousal Care Dyads Living With Chronic Conditions

    ✓ Peer-reviewed Caregiving The journals of gerontology. Series B, Psychological sciences and social sciences

    Key finding: Sleep was correlated more among dyads living with dementia than those with other chronic conditions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2023-03-13

    The gut microbiome modulates the transformation of microglial subtypes

    ✓ Peer-reviewed Disease mechanisms Molecular psychiatry

    Key finding: Clinical and animal studies have shown that gut microbiome disturbances can affect neural function and behaviors via the microbiota-gut-brain axis, and may be implicated in the pathogenesis of several brain diseases. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2023-03-13

    CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Nature aging

    Key finding: These findings suggest that CSF pT217/T217 and pT205/T205 represent improved CSF biomarkers of amyloid and tau pathology in AD.

    Full summary, score breakdown and related studies → Original source

  20. 2023-03-13

    Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads

    ✓ Peer-reviewed Biomarkers EMBO molecular medicine

    Key finding: When simultaneously including plaque and tangle loads, the Aβ42/40 ratio and p-tau231 were only associated with plaques (ρ Aβ42/40 [95%CI] = -0.53[-0.65, -0.35], ρ p-tau231 [95%CI] = 0.28[0.10, 0.43]), GFAP was only associated with tangles (ρ GFAP [95%CI] = 0.39[0.17, 0.57]), and p-tau217 and p-tau181 were associated with both plaques (ρ p-tau217 [95%CI] = 0.40[0.21, 0.56], ρ p-tau181 [95%CI] = 0.36[0.15, 0.50]) and tangles (ρ p-tau217 [95%CI] = 0.52[0.34, 0.66]; ρ p-tau181 [95%CI] = 0.36[0.17, 0.52]). +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2023-03-11

    [18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data

    ✓ Peer-reviewed Biomarkers Journal of neuroinflammation

    Key finding: We selected the cerebellum as a pseudo-reference region based on the immunohistochemical comparison of age-matched PS2APP and WT mice. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2023-03-10

    Racial and Ethnic Differences in Subjective Cognitive Decline - United States, 2015-2020

    ⚠ Report — not peer-reviewed Disparities MMWR. Morbidity and mortality weekly report

    Key finding: College education was associated with a lower prevalence of SCD among all racial and ethnic groups.

    Scored 22 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  23. 2023-03-10

    Disturb mitochondrial associated proteostasis: Neurodegeneration and imperfect ageing

    ✓ Peer-reviewed Disease mechanisms Frontiers in cell and developmental biology

    Key finding: The disease misfolded proteins impact quality control mechanisms of mitochondria, such as fission, fusion, mitophagy, and proteasomal clearance, to the detriment of neuron. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2023-03-10

    Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: High CSF p-tau235 levels were strongly associated with CSF amyloidosis regardless of the clinical diagnosis, being significantly increased in MCI Aβ+ and dementia Aβ+ when compared with all other Aβ- groups (Paris cohort: P ˂0.0001 for all; BIODEGMAR cohort: P ˂0.05 for all). +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2023-03-10

    The complex genetic architecture of Alzheimer's disease: novel insights and future directions

    ✓ Peer-reviewed Inflammation and the immune system EBioMedicine

    Key finding: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →