Newest studies

The smartphone in the memory clinic: A study of patient and care partner's utilisation habits

46/100 ✓ Peer-reviewed Cognitive tests and assessment Neuropsychological rehabilitation

Key finding: Patient participants were less likely to own a smartphone than controls, with increasing age associated with less utilisation of smartphone features in all groups.

• Caregiving
• Digital Tools

Full summary, score breakdown and related studies → Original source

SYNERGIC TRIAL (SYNchronizing Exercises, Remedies in Gait and Cognition) a multi-Centre randomized controlled double blind trial to improve gait and cognition in mild cognitive impairment

75/100 ✓ Peer-reviewed Prevention trials BMC geriatrics

Key finding: The SYNERGIC Trial will establish the efficacy and feasibility of a multimodal intervention to improve cognitive performance and mobility outcomes in MCI. +4 more findings

• Clinical Trials
• Early Stage
• Lifestyle

Full summary, score breakdown and related studies → Original source

Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan

47/100 ✓ Peer-reviewed Inflammation and the immune system Letters in applied microbiology

Key finding: Accumulating evidences link gut microbiota with different diseases and its relationship with neurodegenerative diseases is becoming most intriguing. +3 more findings

• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

TREM2 regulates innate immunity in Alzheimer's disease

40/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

Key finding: The mechanism of this relationship, however, remains unclear. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis

78/100 ✓ Peer-reviewed Caregiving Neuroscience and biobehavioral reviews

Key finding: MRI features of cerebral small vessel disease (CSVD), i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults

58/100 ✓ Peer-reviewed Brain scans and imaging Neurology

Key finding: MeDi groups were comparable for clinical and neuropsychological measures. +1 more finding

• Lifestyle
• Brain Scans
• Biomarkers

Full summary, score breakdown and related studies → Original source

Prevalence of preclinical Alzheimer disease: Comparison of current classification systems

71/100 ✓ Peer-reviewed Genetics Neurology

Key finding: The prevalence of pathologic AD markers was very common (46%) in a representative population sample of 70-year-olds. +2 more findings

• Genetics
• Early Stage

Full summary, score breakdown and related studies → Original source

Education amplifies brain atrophy effect on cognitive decline: implications for cognitive reserve

39/100 ✓ Peer-reviewed Risk factors Neurobiology of aging

Key finding: Importantly, high education was associated with slower decline in individuals with lesser atrophy but with faster decline in those with greater atrophy. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

MicroRNA-Mediated Therapy Modulating Blood-Brain Barrier Disruption Improves Vascular Cognitive Impairment

38/100 ✓ Peer-reviewed Drug development Arteriosclerosis, thrombosis, and vascular biology

Key finding: We here provide the first evidence that the TNFα-miR-501-3p-ZO-1 axis plays an important role in the pathogenesis of cerebral hypoperfusion-induced working memory deficits and white matter lesions, as a result of blood-brain barrier breakdown via tight junction disruption. +3 more findings

• Treatments
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Innate immune memory in the brain shapes neurological disease hallmarks

47/100 ✓ Peer-reviewed Inflammation and the immune system Nature

Key finding: Our results identify immune memory in the brain as an important modifier of neuropathology.

• Brain Biology

Full summary, score breakdown and related studies → Original source

CXCR4 involvement in neurodegenerative diseases

53/100 ✓ Peer-reviewed Disease mechanisms Translational psychiatry

Key finding: Although prior work has identified susceptibility loci associated with various dementias, few, if any, studies have systematically evaluated shared genetic risk across several neurodegenerative diseases. +4 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Aducanumab 36-month data from PRIME: a randomized, double-blind, placebo-controlled Phase 1b study in patients with prodromal or mild Alzheimer’s disease (S2.004)

50/100 ✓ Peer-reviewed Treatments Neurology

Key finding: In patients treated up to 36 months, amyloid plaque levels continued to decrease in a dose- and time-dependent manner, with levels in the 10 mg/kg fixed-dose group reaching and remaining below a quantitative cut-point discriminating a positive/negative scan. 1 Reduced amyloid plaque levels were also observed in patients switched from placebo to aducanumab during the LTE. +4 more findings

• Clinical Trials
• Treatments

Full summary, score breakdown and related studies → Original source

Metabolically healthy obesity and risk of leukoaraiosis; a population based cross-sectional study

59/100 ✓ Peer-reviewed Risk factors Endocrine journal

Key finding: The odds ratios of prevalence of leukoaraiosis were 1.19 (95% CI 0.74-1.90, p = 0.471) for MHO, 1.79 (1.22-2.62, p = 0.003) for MUNO and 1.56 (1.03-2.37, p = 0.037) for MUO individuals after adjusting for sex, age, smoking statues, habit of exercise and alcohol, compared with MHNO individual. +1 more finding

• Risk Factors
• Brain Scans

Full summary, score breakdown and related studies → Original source

Longitudinal Relationship Between Hearing Aid Use and Cognitive Function in Older Americans

64/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: Hearing aids may have a mitigating effect on trajectories of cognitive decline in later life. +1 more finding

• Lifestyle

Full summary, score breakdown and related studies → Original source

Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome

60/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

Key finding: NF-L is a biomarker for neurodegeneration in DS with potential for use in future clinical trials to prevent or delay dementia. +1 more finding

• Biomarkers
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration

43/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurobiology

Key finding: As is typical of most gram-negative bacilli, B. fragilis secretes an unusually complex mixture of neurotoxins including the extremely pro-inflammatory lipopolysaccharide BF-LPS. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

mHealth applications as an educational and supportive resource for family carers of people with dementia: An integrative review

41/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia

Key finding: An integrative literature review approach was used. +4 more findings

• Caregiving

Full summary, score breakdown and related studies → Original source

Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer's Disease using structural MR and FDG-PET images

45/100 ✓ Peer-reviewed Digital health tools Scientific reports

Key finding: Our method delivers 82.4% accuracy in identifying the individuals with mild cognitive impairment (MCI) who will convert to AD at 3 years prior to conversion (86.4% combined accuracy for conversion within 1-3 years), a 94.23% sensitivity in classifying individuals with clinical diagnosis of probable AD, and a 86.3% specificity in classifying non-demented controls improving upon results in published literature.

• Brain Scans
• Digital Tools
• Diagnosis

Full summary, score breakdown and related studies → Original source

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

41/100 ✓ Peer-reviewed Risk factors Frontiers in immunology

Key finding: Several common molecular pathways have been identified that are associated with both aging and low-grade inflammation. +3 more findings

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

β-Amyloid accumulation in the human brain after one night of sleep deprivation

47/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America

Key finding: We show that one night of sleep deprivation, relative to baseline, resulted in a significant increase in Aβ burden in the right hippocampus and thalamus. +4 more findings

• Genetics
• Lifestyle

Full summary, score breakdown and related studies → Original source

Costs of medication in older patients: before and after comprehensive geriatric assessment

45/100 ✓ Peer-reviewed Clinical safety Clinical interventions in aging

Key finding: It was demonstrated that prevalence of polypharmacy, PIM, and PPO could be decreased by CGA including START/STOPP criteria in older adults. +1 more finding

• Treatments
• Policy

Full summary, score breakdown and related studies → Original source

A hypothalamic circuit for the circadian control of aggression

45/100 ✓ Peer-reviewed Clinical safety Nature neuroscience

Key finding: Optogenetic mapping revealed that SPZ GABA neurons receive input from vasoactive intestinal polypeptide suprachiasmatic nucleus neurons and innervate neurons in the ventrolateral part of the ventromedial hypothalamus (VMH), which is known to regulate aggression.

Full summary, score breakdown and related studies → Original source

Vascular Function Is Improved After an Environmental Enrichment Program: The Train the Brain-Mind the Vessel Study

59/100 ✓ Peer-reviewed Treatments Hypertension (Dallas, Tex. : 1979)

Key finding: Compared with controls, patients had at study entry a reduced flow-mediated dilation (2.97±2.14% versus 3.73±2.06%; P =0.03) and hyperemic stimulus (shear rate area under the curve, 19.1±15.7 versus 25.7±15.1×10 -3 ; P =0.009); only the latter remained significant after adjustment for confounders ( P =0.03). +1 more finding

• Clinical Trials

Full summary, score breakdown and related studies → Original source

Advances in Pharmacotherapy of Late-Life Depression

39/100 ✓ Peer-reviewed Risk factors Current psychiatry reports

Key finding: We then review new research on moderators of clinical response and how to use the information for improved efficacy.

Full summary, score breakdown and related studies → Original source

Access to palliative care by disease trajectory: a population-based cohort of Ontario decedents

57/100 ✓ Peer-reviewed End-of-life care BMJ open

Key finding: Terminal illness decedents are more likely to receive any palliative care, with increased intensity and earlier before death than organ failure or frailty decedents. +2 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source