Newest studies

Reproductive period, endogenous estrogen exposure and dementia incidence among women in Latin America and China; A 10/66 population-based cohort study

65/100 ✓ Peer-reviewed Disparities PloS one

Key finding: We found no evidence to support the theory that natural variation in cumulative exposure to endogenous oestrogens across the reproductive period influences dementia incidence in late life. +3 more findings

• Risk Factors

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The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms

48/100 ✓ Peer-reviewed Drug development Translational neurodegeneration

Key finding: The mechanisms that have been hypothesized for each effect are seemingly independent from one another and may explain the contradicting results.

Full summary, score breakdown and related studies → Original source

Use of an Alzheimer's disease polygenic risk score to identify mild cognitive impairment in adults in their 50s

50/100 ✓ Peer-reviewed Disparities Molecular psychiatry

Key finding: Toward that end, we showed that an AD polygenic risk score (PRS) could identify mild cognitive impairment (MCI) in adults who were only in their 50s. +4 more findings

• Early Stage
• Genetics

Full summary, score breakdown and related studies → Original source

Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study

56/100 ✓ Peer-reviewed Genetics The Lancet. Neurology

Key finding: The amyloid β subgroups did not differ for any psychobehavioural, cognitive, actigraphy, and structural and functional neuroimaging results after adjustment for age, sex, and level of education More participants positive for amyloid β deposition had the APOE ε4 allele (33 [38%] vs 29 [13%], p<0·0001).

• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease

55/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's research & therapy

Key finding: Neuroinflammation has gained increasing attention as a potential contributing factor in Alzheimer's disease (AD) pathology. +3 more findings

• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Tau positron emission tomography imaging in tauopathies: The added hurdle of off-target binding

45/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Ligands targeting tau for use with positron emission tomography have rapidly been developed during the past several years, enabling the in vivo study of tau pathology in patients with Alzheimer's disease and related non-Alzheimer's disease tauopathies. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Music therapy in UK palliative and end-of-life care: a service evaluation

43/100 ✓ Peer-reviewed End-of-life care BMJ supportive & palliative care

Key finding: Fifty respondents identified themselves as music therapists currently working with clients receiving PEOLC. +3 more findings

• End-of-Life Care
• Treatments

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CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders

51/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Patients with autopsy-confirmed LBD (n = 24) and autopsy-confirmed Alzheimer disease (AD) (n = 23) and cognitively normal (n = 36) controls were studied. +3 more findings

• Biomarkers
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Contribution of alcohol use disorders to the burden of dementia in France 2008-13: a nationwide retrospective cohort study

68/100 ✓ Peer-reviewed Getting a diagnosis The Lancet. Public health

Key finding: Of 31 624 156 adults discharged from French hospitals between 2008 and 2013, 1 109 343 were diagnosed with dementia and were included in the analyses. +1 more finding

• Diagnosis
• Risk Factors
• Lifestyle

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Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in β-amyloid (1-42) injected rats

38/100 ✓ Peer-reviewed Disease mechanisms Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Key finding: Morris water maze results indicated that compared with the Alzheimer group, the Alzheimer-probiotics group had significantly improved spatial memory, including shorter escape latency and travelled distance and greater time spent in the target quadrant. +1 more finding

• Brain Biology

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Amyloid fibril polymorphism: a challenge for molecular imaging and therapy

38/100 ✓ Peer-reviewed End-of-life care Journal of internal medicine

Key finding: For all NDs, current treatment is palliative without addressing the primary cause and is not curative. +4 more findings

• Treatments
• Brain Scans

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Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-α levels in CSF and serum in relation to the clinical diversity of Parkinson's disease

43/100 ✓ Peer-reviewed Mild cognitive impairment Cellular immunology

Key finding: Significantly elevated serum IL-1β and IL-6 and reduced IL-1RA levels were found in the PD group. +2 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

The Nordic Prudent Diet Reduces Risk of Cognitive Decline in the Swedish Older Adults: A Population-Based Cohort Study

57/100 ✓ Peer-reviewed Prevention trials Nutrients

Key finding: We aimed to identify a Nordic dietary pattern index associated with slower cognitive decline compared to the Mediterranean-DASH Intervention for Neurodegenerative Delay, Mediterranean Diet, Dietary Approaches to Stop Hypertension, and Baltic Sea Diet indices. +2 more findings

• Prevention
• Lifestyle

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Recognition of the complexity facing residential care homes: a practitioner inquiry

39/100 ✓ Peer-reviewed Health systems and care delivery Primary health care research & development

Key finding: In Phase 2 she fed these findings back to other care homes (n=11) to check whether the findings from the single case study were unique or resonated with others.

• Care Services
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Evaluation of Self-reported Patient Experiences: Insights from Digital Patient Communities in Psoriatic Arthritis

45/100 ✓ Peer-reviewed Health systems and care delivery The Journal of Rheumatology

Key finding: Of 15,390 narratives collected from 3139 patients with PsA for exploratory analysis, physical concepts were the most common (81.5%), followed by emotional (50.7%), cognitive (20.0%), role activity (8.1%), and social (5.6%) concepts. +4 more findings

• Digital Tools

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Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

52/100 ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica communications

Key finding: While multiple effective immunomodulatory therapies for MS exist today, they lack the scope of promoting CNS repair, in particular remyelination. +3 more findings

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Vascular cognitive impairment

55/100 ✓ Peer-reviewed Prevention and risk Nature reviews. Disease primers

Key finding: The term vascular cognitive impairment (VCI) was introduced around the start of the new millennium and refers to the contribution of vascular pathology to any severity of cognitive impairment, ranging from subjective cognitive decline and mild cognitive impairment to dementia. +4 more findings

• Other Dementias
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Hearing Loss in the Elderly

39/100 ✓ Peer-reviewed Risk factors Clinics in geriatric medicine

Key finding: Presbycusis, or age-related hearing loss (ARHL), is the result of physiologic and pathologic changes associated with advancing age. +2 more findings

• Risk Factors

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Topographic staging of tau positron emission tomography images

43/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: All three schemes estimated stages that were significantly associated with amyloid status and when dichotomized to tau positive or negative were 90% to 94% concordant in the populations identified. +2 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Predicting cognitive decline with deep learning of brain metabolism and amyloid imaging

66/100 ✓ Peer-reviewed Digital health tools Behavioural brain research

Key finding: The prediction accuracy of the conversion of mild cognitive impairment to AD was compared with the conventional feature-based quantification approach. +2 more findings

• Digital Tools
• Brain Scans

Full summary, score breakdown and related studies → Original source

Twenty years of home-based palliative care in Malappuram, Kerala, India: a descriptive study of patients and their care-givers

45/100 ✓ Peer-reviewed End-of-life care BMC palliative care

Key finding: The changing dynamics over a 20-year period of this palliative care programme in Kerala, India, highlights the need for similar programmes to remain flexible and adapt their services in response to a growing global burden of Non Communicable Diseases. +1 more finding

• End-of-Life Care
• Caregiving

Full summary, score breakdown and related studies → Original source

Measuring cognition and function in the preclinical stage of Alzheimer's disease

45/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (New York, N. Y.)

Key finding: The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. +2 more findings

• Treatments
• Early Stage

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Antimicrobial therapy in palliative care: an overview

38/100 ✓ Peer-reviewed End-of-life care Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Key finding: In the advanced stages of illness, patients often face challenging decisions regarding their treatment and overall medical care.

• End-of-Life Care
• Treatments

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Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults

56/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

Key finding: This analysis combining data from two health systems shows that area deprivation is an independent risk factor for cognitive dysfunction in older adults. +2 more findings

• Health Equity
• Risk Factors

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Decreased hemodynamic response in inferior frontotemporal regions in elderly with mild cognitive impairment

40/100 ✓ Peer-reviewed Digital health tools Psychiatry research. Neuroimaging

Key finding: We found a decreased hemodynamic response in the inferior frontotemporal cortex for the MCI group. +1 more finding

• Early Stage
• Other Dementias

Full summary, score breakdown and related studies → Original source