Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,601–26,625 of 27,380 studies, newest first · page 1065 of 1096.
November 1994 9
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1994-11-01
The Canadian Study of Health and Aging: risk factors for Alzheimer's disease in Canada
59/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: This study confirmed a number of previously reported risk factors for AD, but provided little support for others. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-11-01
The MDS Cognition Scale: a valid instrument for identifying and staging nursing home residents with dementia using the minimum data set
52/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society
Key finding: We report the development and validation of an MDS-based cognitive index, the MDS Cognition Scale (MDS-COGS), by evaluating it against two popular dementia rating scales, the Global Deterioration Scale (GDS) and the Mini-Mental State Examination (MMSE). +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-11-01
Non-fibrillar beta-amyloid protein is associated with smooth muscle cells of vessel walls in Alzheimer disease
40/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of neuropathology and experimental neurology
Key finding: Serial sections were stained with thioflavine S and Congo red and immunostained for the presence of beta-amyloid precursor protein (beta PP) and beta-protein and for smooth muscle-specific proteins myosin, alpha-actin, and desmin. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-11-01
Conformation and fibrillogenesis of Alzheimer A beta peptides with selected substitution of charged residues
44/100 ✓ Peer-reviewed Risk genes beyond APOE Journal of molecular biology
Key finding: The major component is the 39 to 42 residue amyloid beta protein (A beta), which is an internal proteolytic fragment of the membrane-associated amyloid precursor protein. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-11-01
High expression on Kunitz-type protease inhibitor-containing substances in the cerebral vessels of patients with Down syndrome
28/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The Tohoku journal of experimental medicine
Key finding: The high expression of KPI in DS vessels may be one of the predisposing factors to vascular diseases and amyloid deposition associated with DS.
Full summary, score breakdown and related studies → Original source
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1994-11-01
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease
49/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: In vitro, tau binds avidly to apoE3, but not to apoE4, forming a bimolecular complex. +4 more findings
Full summary, score breakdown and related studies → Original source
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1994-11-01
Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments
57/100 ✓ Peer-reviewed Genetics Nature
Key finding: The protease inhibitor alpha 1-antichymotrypsin and the lipid transport protein apolipoprotein E (apoE) are intimately associated with the 42-amino-acid beta-peptide (A beta) in the filamentous amyloid deposits of Alzheimer's disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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1994-11-01
Gene expression in Alzheimer neocortex as a function of age and pathologic severity
32/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: Northern analysis revealed a marked (> 50%) decline in expression of transcripts for the neurofilament light subunit and the major amyloid precursor protein (APP) isoforms in both PAD and SAD. +1 more finding
Full summary, score breakdown and related studies → Original source
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1994-11-01
S100 beta protein expression in Alzheimer disease: potential role in the pathogenesis of neuritic plaques
41/100 ✓ Peer-reviewed Biomarkers Journal of neuroscience research
Key finding: In AD, tissue levels of S100 beta (two- to fivefold that of controls) were significantly correlated with the number of Tau-2+ plaques (R = 0.82, P < .01). +3 more findings
Full summary, score breakdown and related studies → Original source
October 1994 4
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1994-10-01
One hundred years of schizophrenia: a meta-analysis of the outcome literature
79/100 ✓ Peer-reviewed Getting a diagnosis The American journal of psychiatry
Key finding: Overall, less than half of patients diagnosed with schizophrenia have shown substantial clinical improvement after follow-up averaging nearly 6 years. +4 more findings
Full summary, score breakdown and related studies → Original source
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1994-10-01
Risk of dementia after stroke in a hospitalized cohort: results of a longitudinal study
47/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: The RR of dementia associated with stroke compared with controls was 5.5 (95% CI, 2.5 to 11.1) after adjusting for demographic factors. +2 more findings
Full summary, score breakdown and related studies → Original source
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1994-10-01
Clinical characteristics of a family with chromosome 17-linked disinhibition-dementia-parkinsonism-amyotrophy complex
49/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: We studied the neuropathology of six individuals, five of whom had been examined in life. +4 more findings
Full summary, score breakdown and related studies → Original source
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1994-10-01
Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome
43/100 ✓ Peer-reviewed Caregiving Annals of neurology
Key finding: Like others, we found that multinucleated giant cells were present in only half of the dementia patients.
Full summary, score breakdown and related studies → Original source
September 1994 12
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1994-09-01
Isoform-specific binding of apolipoprotein E to beta-amyloid
40/100 ✓ Peer-reviewed Genetics Journal of Biological Chemistry
Key finding: ApoE is present in the extracellular senile plaques and intracellular neurofibrillary tangles associated with Alzheimer's disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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1994-09-01
Estrogen replacement therapy in older women. Comparisons between Alzheimer's disease cases and nondemented control subjects
59/100 ✓ Peer-reviewed Risk factors Archives of neurology
Key finding: Alzheimer's disease case patients were significantly less likely than control subjects to use estrogen replacement (7% vs 18%), but groups did not differ with regard to the total number of prescription medications or to the most frequently prescribed class of drug (thyroid medication). +2 more findings
Full summary, score breakdown and related studies → Original source
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1994-09-01
Rapid induction of Alzheimer A beta amyloid formation by zinc
41/100 ✓ Peer-reviewed Tau biomarkers Science (New York, N.Y.)
Key finding: It has been shown that human A beta specifically and saturably binds zinc.
Full summary, score breakdown and related studies → Original source
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1994-09-01
Clinical-neuropathological correlations in Alzheimer's disease and related dementias
60/100 ✓ Peer-reviewed Vascular contributions Archives of neurology
Key finding: Clinicians accurately predicted AD pathological findings or their absence in most cases. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-09-01
Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography
42/100 ✓ Peer-reviewed Inflammation and the immune system Neuroscience
Key finding: Monoamine oxidase type B is known to be increased in Alzheimer diseased brains. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-09-01
Mitochondrial DNA sequence variation in human evolution and disease
44/100 ✓ Peer-reviewed Brain tissue and pathology Proceedings of the National Academy of Sciences of the United States of America
Key finding: Germ-line mtDNA mutations, both ancient and recent, have been associated with a variety of degenerative diseases. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-09-01
The Mini-Mental State Examination score and the clinical diagnosis of dementia
44/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of clinical epidemiology
Key finding: All patients were later given a complete, standardized work-up and diagnosis as part of our Alzheimer's Disease Patient Registry protocol. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-09-01
Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers
55/100 ✓ Peer-reviewed Cognitive tests and assessment Dementia (Basel, Switzerland)
Key finding: This battery, which is based on tests used to identify the neural substrates of learning and memory in non-human primates, has now been extensively used in the assessment of various forms of dementia and also validated on patients with neurosurgical lesions of the frontal and temporal lobes. +3 more findings
Full summary, score breakdown and related studies → Original source
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1994-09-01
Age, adaptive behavior, and Alzheimer disease in Down syndrome: cross-sectional and longitudinal analyses
37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of mental retardation : AJMR
Key finding: Cross-sectional analysis showed significant differences related to level of functioning but not to age or etiology of disability. +1 more finding
Full summary, score breakdown and related studies → Original source
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1994-09-01
Measurement of severity in advanced Alzheimer's disease
44/100 ✓ Peer-reviewed Digital health tools Journal of gerontology
Key finding: BANS-S may be a useful tool for the evaluation of different treatment strategies in severe DAT and for the correlation of clinical and pathological findings.
Full summary, score breakdown and related studies → Original source
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1994-09-01
Apolipoprotein E epsilon 4 allele in Alzheimer's disease and vascular dementia
38/100 ✓ Peer-reviewed Genetics Dementia (Basel, Switzerland)
Key finding: We found that the frequency of the apoE epsilon 4 allele was 0.45 in 93 Alzheimer's disease patients, 0.46 in 23 vascular dementia patients, 0.31 in 13 dementia of the frontal type patients, and 0.18 in 51 elderly controls.
Full summary, score breakdown and related studies → Original source
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1994-09-01
Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease
45/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: Neuropathological findings in three aged chimpanzees were compared with those in rhesus monkeys and individuals with Alzheimer disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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