Newest studies

Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts

58/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Although Aβ did not differ by sex, cognitive decline was greater in females with higher Aβ. +2 more findings

• Genetics
• Early Stage

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Racial and Ethnic Disparities in Dementia Risk Among Individuals With Low Education

54/100 ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: As indicated by Cox regression modeling, dementia risk of low-educated individuals was not significantly different between ethnic groups but was related to having an APOE e4 allele (hazard ratio [HR] 1.89), depression (HR 1.67), stroke (HR 1.60), and smoking (HR 1.32). +2 more findings

• Health Equity
• Risk Factors
• Genetics

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Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease

41/100 ✓ Peer-reviewed Genetics Molecular neurodegeneration

Key finding: Gene ontology analyses coupled with bioinformatics approaches revealed drug targets and transcriptional regulators of microglial modules predicted to favorably modulate neuroinflammation in AD. +3 more findings

• Brain Biology
• Genetics
• Treatments

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Cerebral small vessel disease and the risk of dementia: A systematic review and meta-analysis of population-based evidence

79/100 ✓ Peer-reviewed Vascular contributions Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: White matter hyperintensities are associated with an increased risk of all-dementia and Alzheimer's disease in the general population. +2 more findings

• Risk Factors
• Other Dementias

Full summary, score breakdown and related studies → Original source

PET staging of amyloidosis using striatum

57/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: PET can evaluate amyloid expansion from cortex to subcortex.

• Brain Scans

Full summary, score breakdown and related studies → Original source

Cognitive training for freezing of gait in Parkinson's disease: a randomized controlled trial

57/100 ✓ Peer-reviewed Prevention trials NPJ Parkinson's disease

Key finding: The primary outcome of percentage time spent frozen during a gait task was significantly improved in the CT group compared to active controls in the on-state. +2 more findings

• Clinical Trials
• Lifestyle
• Other Dementias

Full summary, score breakdown and related studies → Original source

Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia

58/100 ✓ Peer-reviewed Long-term cohort studies NeuroImage

Key finding: Total hippocampal volume has been consistently linked to cognitive function and dementia. +3 more findings

• Risk Factors

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In Vivo Characterization and Quantification of Neurofibrillary Tau PET Radioligand 18F-MK-6240 in Humans from Alzheimer Disease Dementia to Young Controls

52/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: SUVs in the pons and the inferior cerebellum indicated consistent clearance across all 51 subjects. +4 more findings

• Brain Scans
• Brain Biology

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GWAS on family history of Alzheimer's disease

81/100 ✓ Peer-reviewed Prevention and risk Translational psychiatry

Key finding: These contain genes relevant for AD and neurodegeneration: ADAM10, BCKDK/KAT8 and ACE. +4 more findings

• Genetics

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Impact of Reference and Target Region Selection on Amyloid PET SUV Ratios in the Phase 1b PRIME Study of Aducanumab

62/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Of the reference regions used, subcortical white matter, cerebellar white matter, and the pons, alone or in combination, generated the largest effect sizes. +4 more findings

• Treatments
• Brain Scans

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The cingulum bundle: Anatomy, function, and dysfunction

41/100 ✓ Peer-reviewed Risk factors Neuroscience and biobehavioral reviews

Key finding: To help understand its complex structure, this review begins with detailed, comparative descriptions of the multiple connections comprising the cingulum bundle. +4 more findings

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Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity

41/100 ✓ Peer-reviewed Clinical safety Life science alliance

Key finding: Here, the neuronal interactomes of cytoplasmic GFP-(GR) 149 and nucleolar (PR) 175 -GFP revealed overlapping RNA-binding proteins, including components of stress granules, nucleoli, and ribosomes. +1 more finding

• Side Effects
• Brain Biology

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Transitions to long-term and residential care among older Canadians

48/100 ✓ Peer-reviewed Health systems and care delivery Health reports

Key finding: On Census Day, 1.4% of the study sample were living in a nursing home, 1.2% in a seniors' residence, 7.1% in a private dwelling with additional family, and 90.3% in a private dwelling. +4 more findings

• Care Services

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Better diet quality relates to larger brain tissue volumes: The Rotterdam Study

61/100 ✓ Peer-reviewed Long-term cohort studies Neurology

Key finding: From the population-based Rotterdam Study, 4,447 participants underwent dietary assessment and brain MRI scanning between 2005 and 2015. +3 more findings

• Lifestyle

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Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial

78/100 ✓ Peer-reviewed Treatments BMJ

Key finding: A moderate to high intensity aerobic and strength exercise training programme does not slow cognitive impairment in people with mild to moderate dementia.

• Clinical Trials
• Lifestyle

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Processed electroencephalogram and evoked potential techniques for amelioration of postoperative delirium and cognitive dysfunction following non-cardiac and non-neurosurgical procedures in adults

84/100 ✓ Peer-reviewed Clinical safety The Cochrane database of systematic reviews

Key finding: We found moderate-quality evidence that postoperative cognitive dysfunction at three months could be reduced in these patients. +4 more findings

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Serum phosphate levels are related to all-cause, cardiovascular and COPD mortality in men

48/100 ✓ Peer-reviewed Long-term cohort studies European journal of epidemiology

Key finding: To investigate the association between phosphate (P) levels and all-cause and cause-specific mortality, we assessed two cohorts from the Rotterdam Study, with follow-up of 14.5 (RS-I) and 10.9 (RS-II) years until January 2012 with availability of fasting phosphate levels. +3 more findings

• Risk Factors

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Modulation of functional activity and connectivity by acupuncture in patients with Alzheimer disease as measured by resting-state fMRI

47/100 ✓ Peer-reviewed Brain scans and imaging PloS one

Key finding: During the baseline resting state, by using the amplitude of low-frequency fluctuations (ALFF), we found a significantly decreased or increased ALFF in the AD patients relative to the controls. +1 more finding

• Brain Scans

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Alzheimer Disease and Mild Cognitive Impairment: Integrated Pulsed Arterial Spin-Labeling MRI and 18F-FDG PET

47/100 ✓ Peer-reviewed Brain scans and imaging Radiology

Key finding: Analyses revealed high overlap between components, regional and quantitative hypoperfusion, and hypometabolism in patients with AD compared with HC participants in precuneus, parietal, temporal, and occipital cortex. +4 more findings

• Brain Scans
• Early Stage

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Emerging Applications of Optical Coherence Tomography Angiography (OCTA) in neurological research

39/100 ✓ Peer-reviewed Brain scans and imaging Eye and vision (London, England)

Key finding: OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders. +4 more findings

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Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study

54/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood. +3 more findings

• Early Stage
• Risk Factors

Full summary, score breakdown and related studies → Original source

Adaptive template generation for amyloid PET using a deep learning approach

39/100 ✓ Peer-reviewed Brain scans and imaging Human brain mapping

Key finding: The proposed deep learning approach significantly enhanced the quantitative accuracy of MRI-less amyloid PET assessment by reducing the SN error observed when an average amyloid PET template is used.

• Brain Scans
• Digital Tools

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Old Drugs as New Treatments for Neurodegenerative Diseases

41/100 ✓ Peer-reviewed Drug development Pharmaceuticals (Basel, Switzerland)

Key finding: This last source is known as drug repurposing, which is the most advantageous, since the drug’s pharmacokinetic and pharmacodynamic profiles are already established, and the investment put into this strategy is not as significant as for the classic development of new drugs.

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Rich club disturbances of the human connectome from subjective cognitive decline to Alzheimer's disease

51/100 ✓ Peer-reviewed Mild cognitive impairment Theranostics

Key finding: We demonstrated that rich club organization was disrupted, with reduced structural connectivity among rich club nodes, in aMCI and d-AD patients but remained stable in SCD patients. +4 more findings

• Early Stage

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Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia

63/100 ✓ Peer-reviewed Genetics Stroke

Key finding: Genetic variants within the VCAN gene may play a role in the mechanisms underlying microstructural integrity of the white matter in the brain measured as FA and MD. +3 more findings

• Genetics

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