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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 14,351–14,375 of 27,380 studies, newest first · page 575 of 1096.

January 2018 25

  1. 2018-01-09

    White matter degeneration in vascular and other ageing-related dementias

    ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry

    Key finding: Leukoaraiosis or rarefied white matter (WM) originally described on computed tomography is one of the most prominent changes which occurs in older age. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2018-01-09

    The Cost-Effectiveness of Using PARO, a Therapeutic Robotic Seal, to Reduce Agitation and Medication Use in Dementia: Findings from a Cluster-Randomized Controlled Trial

    ✓ Peer-reviewed Digital health tools Journal of the American Medical Directors Association

    Key finding: The plush toy used in this study offered marginally greater value for money than PARO in improving agitation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2018-01-09

    Declines in Connected Language Are Associated with Very Early Mild Cognitive Impairment: Results from the Wisconsin Registry for Alzheimer's Prevention

    ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience

    Key finding: Measures of lexical diversity and grammatical complexity were not associated with eMCI status in this group. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2018-01-08

    TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

    ✓ Peer-reviewed Lewy body dementia Nature neuroscience

    Key finding: However, the composition of aggregates and their contribution to the disease process remain unknown. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2018-01-07

    The mitochondrial ATP synthase is a shared drug target for aging and dementia

    ✓ Peer-reviewed Clinical safety Aging cell

    Key finding: J147 was developed using a series of phenotypic screening assays mimicking disease toxicities associated with the aging brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2018-01-06

    Presynaptic endocytic factors in autophagy and neurodegeneration

    ✓ Peer-reviewed Disease mechanisms Current opinion in neurobiology

    Key finding: These findings reveal unanticipated connections between the machineries for synaptic neurotransmission and neuronal proteostasis and identify presynaptic endocytic proteins as potential targets to treat neurodegenerative diseases.

    Full summary, score breakdown and related studies → Original source

  7. 2018-01-06

    Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

    ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Circulating metabolites were consistently associated with cognition, dementia, and lifestyle factors, opening new avenues for prevention of cognitive decline and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2018-01-04

    Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

    ✓ Peer-reviewed Inflammation and the immune system FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Key finding: Furthermore, exosomes from hypoxic progenitor cells exerted better therapeutic effects in organ injury through specific cargoes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2018-01-04

    The effectiveness of physical exercise on cognitive and psychological outcomes in individuals with mild cognitive impairment: A systematic review and meta-analysis

    ✓ Peer-reviewed Prevention and risk International journal of nursing studies

    Key finding: Physical exercise, aerobic exercise in particular, benefits global cognition in MCI patients. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2018-01-02

    A refined concept: α-synuclein dysregulation disease

    ✓ Peer-reviewed Brain tissue and pathology Neurochemistry international

    Key finding: Recent advances in therapeutic approaches offer new antibody-, vaccine-, antisense-oligonucleotide- and small molecule-based options to reduce αSyn protein levels and aggregates in patient's brain. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2018-01-02

    Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech

    ✓ Peer-reviewed Brain scans and imaging Cortex; a journal devoted to the study of the nervous system and behavior

    Key finding: The PPAOS group (n = 14) showed increased tau-PET uptake in the precentral gyrus, supplementary motor area and Broca's area compared to controls.

    Full summary, score breakdown and related studies → Original source

  12. 2018-01-02

    Long-Lasting Neuropsychological Effects of a Computerized Cognitive Training in Patients Affected by Early Stage Alzheimer's Disease: Are They Stable Over Time?

    ✓ Peer-reviewed Cognitive tests and assessment Journal of applied gerontology : the official journal of the Southern Gerontological Society

    Key finding: Patients in the experimental group showed a significant improvement in various neuropsychological domains due to the training, and these effects decreased after 12 months. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2018-01-02

    Alternations of Metabolic Profile and Kynurenine Metabolism in the Plasma of Parkinson's Disease

    ✓ Peer-reviewed Biomarkers Molecular neurobiology

    Key finding: Lower kynurenic acid (KA)/KYN ratio, higher quinolinic acid (QA) level, and QA/KA ratio were observed in PD patients compared to HD patients and NCs. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2018 year only

    Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer's Disease

    ✓ Peer-reviewed Disease mechanisms Journal of Alzheimer's disease : JAD

    Key finding: We found that 6-7, but not 2-3-month-old rTg4510 mice exhibited reduced pre-synaptic activation (fiber volley (FV) amplitude, ∼50%) and field excitatory post-synaptic potential (fEPSP) slope (∼40%) compared to wild-type controls. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2018 year only

    Nutrition and Ageing

    ✓ Peer-reviewed Prevention and risk Sub-cellular biochemistry

    Key finding: In humans, plant-based diets such as the Mediterranean dietary pattern are associated with healthier ageing and lower risk of age-related disease, whereas obesity accelerates ageing and increases the likelihood of most common complex diseases including CVD, T2D, dementia, musculoskeletal diseases and several cancers. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2018 year only

    Late-life Depression and Alzheimer Disease: A Potential Synergy of the Underlying Mechanisms

    ✓ Peer-reviewed Risk factors Current medicinal chemistry

    Key finding: The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.

    Full summary, score breakdown and related studies → Original source

  17. 2018 year only

    Metabolic Syndrome and Amyloid Accumulation in the Aging Brain

    ✓ Peer-reviewed Risk factors Journal of Alzheimer's disease : JAD

    Key finding: A total of 165 cognitively normal participants of the Baltimore Longitudinal Study of Aging (BLSA) Neuroimaging substudy, aged 55-92 years (mean baseline age = 76.4 years, 85 participants were male), received an average of 2.5 PET-PiB scans over an average interval of 2.6 (3.08 SD) years between first and last visits. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2018 year only

    Metabolic Syndrome and Its Effect on the Brain: Possible Mechanism

    ✓ Peer-reviewed Risk factors CNS & neurological disorders drug targets

    Key finding: In this review, we will discuss the possible mechanisms which may relate the association between MetS and cognitive decline which include vascular damages, elevation of reactive oxygen species (ROS), insulin resistance and low-grade inflammation.

    Full summary, score breakdown and related studies → Original source

  19. 2018 year only

    [Sleep and wakefulness disorders in neurodegenerative diseases]

    ✓ Peer-reviewed Risk factors Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    Key finding: The article reviews the phenomenology of sleep and wakefulness disorders in Parkinson's disease and Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2018 year only

    The Integrated Alzheimer's Disease Rating Scale (iADRS) Findings from the EXPEDITION3 Trial

    ✓ Peer-reviewed Clinical trials The journal of prevention of Alzheimer's disease

    Key finding: A statistically significant difference between placebo and active drug was observed for iADRS score change from baseline at Week 28 (p=0.028) through Week 80 (p=0.015). +1 more finding

    Full summary, score breakdown and related studies → Original source

  21. 2018 year only

    France Will No More Reimburse Available Symptomatic Drugs Against Alzheimer's Disease

    ✓ Peer-reviewed Treatments Journal of Alzheimer's disease : JAD

    Key finding: This follows the advice delivered by the High Authority for Health in 2016 and 2018 stating an "insufficient medical benefit and dangerousness because of significant side effects".

    Full summary, score breakdown and related studies → Original source

  22. 2018 year only

    Drusen in the Peripheral Retina of the Alzheimer's Eye

    ✓ Peer-reviewed Brain scans and imaging Current Alzheimer research

    Key finding: There was a significant increase in the total number of macular and peripheral hard drusen in older, compared to younger, normal eyes (p<0.05). +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2018 year only

    Default Mode Network Lateralization and Memory in Healthy Aging and Alzheimer's Disease

    ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD

    Key finding: No differences in overall network connectivity between groups were observed, suggesting that the functional lateralization finding is not secondary to general changes in connectivity. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2018 year only

    Amyloid PET Imaging: Standardization and Integration with Other Alzheimer's Disease Biomarkers

    ✓ Peer-reviewed Brain scans and imaging Methods in molecular biology (Clifton, N.J.)

    Key finding: Amyloid plaques are a neuropathologic hallmark of Alzheimer's disease (AD), which can be imaged through positron emission tomography (PET) technology using radiopharmaceuticals that selectively bind to the fibrillar aggregates of amyloid-β plaques (Amy-PET). +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2018 year only

    Depression and Alzheimer's Disease Biomarkers Predict Driving Decline

    ✓ Peer-reviewed Brain scans and imaging Journal of Alzheimer's disease : JAD

    Key finding: Data were available from 131 participants with age ranging from 65.4 to 88.2 years and mean follow up of 2.4 years (SD = 1.0). +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →