Newest studies

Longitudinal tau PET in ageing and Alzheimer's disease

57/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

Key finding: At a group-wise level, observable rates of short-term serial tau accumulation were only seen in the presence of abnormal amyloid. +4 more findings

• Brain Scans

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Comparison of multiple interventions for older adults with Alzheimer disease or mild cognitive impairment: A PRISMA-compliant network meta-analysis

83/100 ✓ Peer-reviewed Cognitive tests and assessment Medicine

Key finding: As the first NMA comparing different interventions for AD and MCI, our study suggests that PE and CCT might have a significant improvement in cognition and neuropsychiatric symptoms respectively. +3 more findings

• Diagnosis
• Early Stage
• Treatments

Full summary, score breakdown and related studies → Original source

Amyloid blood biomarker detects Alzheimer's disease

52/100 ✓ Peer-reviewed Biomarkers EMBO molecular medicine

Key finding: Diagnostic tools for detection of AD are either invasive like cerebrospinal fluid (CSF) biomarkers or expensive such as positron emission tomography (PET) scanning. +4 more findings

• Biomarkers
• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Trauma-Informed Hospice and Palliative Care

38/100 ✓ Peer-reviewed End-of-life care The Gerontologist

Key finding: Moreover, there is emerging evidence for multiple additional opportunities for exposure to psychological trauma at or near the end of life. +4 more findings

• End-of-Life Care

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Cognitive Effects of Multi-Domain Interventions Among Pre-Frail and Frail Community-Living Older Persons: Randomized Controlled Trial

66/100 ✓ Peer-reviewed Prevention trials The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: Among frail older persons, cognitive training conferred the greatest cognitive benefits. +2 more findings

• Clinical Trials

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Be a Super Shopper!

25/100 ✓ Peer-reviewed Risk factors Better Safe Than Sorry

Key finding: This chapter examines how grocery stores and Whole Foods Market in particular, have driven the rise of precautionary consumption. +3 more findings

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Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

58/100 ✓ Peer-reviewed TREM2 and immune genetics Cell

Key finding: Accumulating evidence suggests that disease-associated microglia (DAM), a recently identified subset of CNS resident macrophages found at sites of neurodegeneration, might play such a protective role. +2 more findings

• Brain Biology

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Data-driven models of dominantly-inherited Alzheimer's disease progression

67/100 ✓ Peer-reviewed Risk genes beyond APOE Brain : a journal of neurology

Key finding: We use emerging techniques in generative data-driven disease progression modelling to characterize dominantly-inherited Alzheimer's disease progression with unprecedented resolution, and without relying upon familial estimates of years until symptom onset. +3 more findings

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Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer's disease

54/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology

Key finding: The results demonstrated that regional spectral patterns of resting state activity could be separated into several types of MEG signatures as follows: (i) the effects of amyloid-β deposition were expressed as the alpha band power augmentation in medial frontal areas; (ii) the delta band power increase in the same region was associated with disease progression within the Alzheimer's disease continuum and was correlated with entorhinal atrophy and an Alzheimer's disease-like regional decrease in glucose metabolism; and (iii) the global theta power augmentation, which was previously considered to be an Alzheimer's disease-related EEG/MEG signature, was associated with general cognitive decline and hippocampal atrophy, but was not specific to Alzheimer's disease because these changes could be observed in the absence of amyloid-β deposition. +1 more finding

• Early Stage
• Brain Scans

Full summary, score breakdown and related studies → Original source

Speech-Language Pathologist Interventions for Communication in Moderate-Severe Dementia: A Systematic Review

53/100 ✓ Peer-reviewed Digital health tools American journal of speech-language pathology

Key finding: Preliminary evidence was found to support communication interventions for people with moderate-severe dementia. +1 more finding

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Sleep disorders in the elderly: a growing challenge

46/100 ✓ Peer-reviewed How common it is Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Key finding: Other common medical problems of old age such as hypertension diabetes mellitus, renal failure, respiratory diseases such as asthma, immune disorders, gastroesophageal reflux disease, physical disability, dementia, pain, depression, and anxiety are all associated with sleep disturbances.

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Neurotransmitter deficits from frontotemporal lobar degeneration

56/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology

Key finding: Frontotemporal lobar degeneration causes a spectrum of complex degenerative disorders including frontotemporal dementia, progressive supranuclear palsy and corticobasal syndrome, each of which is associated with changes in the principal neurotransmitter systems.

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease

60/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology

Key finding: Compared with noncarriers, cognitively unimpaired mutation carriers had elevated mean cortical Pittsburgh Compound B distribution volume ratio levels in their late 20s, and 7 of 9 carriers older than 30 years reached the threshold for amyloidosis (distribution volume ratio level > 1.2). +3 more findings

• Brain Scans
• Genetics

Full summary, score breakdown and related studies → Original source

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

61/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology

Key finding: Preclinical AD is associated with rest-activity rhythm fragmentation, independent of age or sex. +4 more findings

• Early Stage

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Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease

82/100 ✓ Peer-reviewed Treatments The New England journal of medicine

Key finding: Verubecestat did not reduce cognitive or functional decline in patients with mild-to-moderate Alzheimer's disease and was associated with treatment-related adverse events. +2 more findings

• Clinical Trials

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Projections of multi-morbidity in the older population in England to 2035: estimates from the Population Ageing and Care Simulation (PACSim) model

72/100 ✓ Peer-reviewed Prevention and risk Age and ageing

Key finding: Little is known on how risk factors of younger cohorts will play out in the future burden of multi-morbidity (two or more concurrent long-term conditions). +1 more finding

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[Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model.]

33/100 ✓ Peer-reviewed Biomarkers Biomedica : revista del Instituto Nacional de Salud

Key finding: Our work suggests an anti-inflammatory effect of quercetin in the CA1 hippocampal region of aged triple transgenic Alzheimer's disease mice. +1 more finding

• Brain Biology

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Abnormal clotting of the intrinsic/contact pathway in Alzheimer disease patients is related to cognitive ability

36/100 ✓ Peer-reviewed Biomarkers Blood advances

Key finding: Utilizing clinically relevant assays, thromboelastography and activated partial thromboplastin time, we found impaired clot initiation and formation rate in AD patient plasma. +4 more findings

• Biomarkers
• Brain Biology

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Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease

44/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in neuroscience

Key finding: We recently developed a polygenic hazard score (PHS) that predicted age of AD onset above and beyond APOE . +3 more findings

• Early Stage
• Genetics

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Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

65/100 ✓ Peer-reviewed Long-term cohort studies Ophthalmology

Key finding: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3-82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. +3 more findings

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Could Alzheimer's Disease Originate in the Periphery and If So How So?

46/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurobiology

Key finding: Here, an alternative molecular neurobiological model is proposed. +3 more findings

• Genetics

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Plasma Biomarkers Differentiate Parkinson’s Disease From Atypical Parkinsonism Syndromes

55/100 ✓ Peer-reviewed Biomarkers Frontiers in Aging Neuroscience

Key finding: Plasma a-synuclein level was significantly increased in patients with PD and APS when compared with controls and FTD without parkinsonism (p<0.01). +4 more findings

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Human brain arousal in the resting state: a genome-wide association study

57/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: At the SNP-level, GWAS analyses revealed no genome-wide significant locus (p < 5E-8), although seven loci were suggestive (p < 1E-6). +4 more findings

• Genetics

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Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice

41/100 ✓ Peer-reviewed Disease mechanisms Scientific reports

Key finding: Recent studies suggest that neurovascular integrity could be regulated by the gut microbiome. +4 more findings

• Brain Biology
• Lifestyle

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Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity

38/100 ✓ Peer-reviewed Drug development Brain research

Key finding: Recent studies indicate that metabolic disorders such as diabetes and obesity are a major risk factor of psychiatric diseases. +3 more findings

• Treatments
• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source