Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,776–12,800 of 27,380 studies, newest first · page 512 of 1096.
June 2019 22
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2019-06-06
Association of 3-Year Multidomain Intervention and Omega-3 Supplementation with Frailty Incidence
64/100 ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society
Key finding: In community-dwelling older persons, the combination of a long-term lifestyle MI and omega-3 supplementation did not reduce frailty level or incidence. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-05
Tau Positron Emission Tomography Binding Is Not Elevated in HIV-Infected Individuals
39/100 ✓ Peer-reviewed Brain scans and imaging The Journal of infectious diseases
Key finding: Older HIV-positive individuals are not at increased risk of tau-mediated neurodegeneration.
Full summary, score breakdown and related studies → Original source
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2019-06-04
The costs of dementia subtypes to California Medicare fee-for-service, 2015
46/100 ✓ Peer-reviewed Costs and economics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: 3,001,987 Medicare beneficiaries were identified, of which 8.2% had a dementia diagnosis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-04
Self-reported needs and experiences of people with dementia living in nursing homes: a scoping review
45/100 ✓ Peer-reviewed End-of-life care Aging & mental health
Key finding: A total of 41 articles met the eligibility criteria. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-04
Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
77/100 ✓ Peer-reviewed Prevention trials Alzheimer's research & therapy
Key finding: The FINGER MRI exploratory sub-study did not show significant differences between the intervention and control groups on changes in regional brain volumes, regional cortical thicknesses, or WML volume after 2 years in at-risk elderly without substantial impairment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-04
Measuring gait speed to better identify prodromal dementia
64/100 ✓ Peer-reviewed Caregiving Experimental gerontology
Key finding: Of 39 studies selected, including overall 57,456 participants, 33 reported a significant association between gait speed and cognitive outcomes, including dementia.
Full summary, score breakdown and related studies → Original source
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2019-06-03
Single-cell transcriptomics unveils gene regulatory network plasticity
41/100 ✓ Peer-reviewed Genetics Genome biology
Key finding: We devise a conceptually different computational framework based on a holistic view, where single-cell datasets are used to infer global, large-scale regulatory networks. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-03
Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors
49/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration
Key finding: Autophagy and endolysosomal homeostasis need to be maintained throughout life as they are major cellular mechanisms involved in both the production of toxic amyloid peptides and the clearance of misfolded or aggregated proteins. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-06 month only
HDL from an Alzheimer's disease perspective
39/100 ✓ Peer-reviewed Vascular contributions Current opinion in lipidology
Key finding: RECENT FINDINGS: Many epidemiological studies have observed that circulating HDL levels associate with decreased Alzheimer's disease risk. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-01
Deaths: Leading Causes for 2017
38/100 ✓ Peer-reviewed Disparities National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System
Key finding: In 2017, the 10 leading causes of death were, in rank order: Diseases of heart; Malignant neoplasms; Accidents (unintentional injuries); Chronic lower respiratory diseases; Cerebrovascular diseases; Alzheimer disease; Diabetes mellitus; Influenza and pneumonia; Nephritis, nephrotic syndrome and nephrosis; and Intentional self-harm (suicide).
Full summary, score breakdown and related studies → Original source
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2019-06-01
Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody
45/100 ✓ Peer-reviewed Drug development Brain : a journal of neurology
Key finding: Second, by using K18 P301L tau fibrils to induce pathology, we further demonstrated that antibody D was also capable of blocking the progression of tau pathology to distal brain regions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-06-01
Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease
41/100 ✓ Peer-reviewed Prevention trials Current nutrition reports
Key finding: Nutrition is known to modulate the immune system and may alter neuroinflammatory processes implicated in the pathogenesis of Alzheimer's disease (AD) and progression of neurodegeneration.
Full summary, score breakdown and related studies → Original source
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2019-06-01
The efficacy and underlying mechanism of phosphodiesterase- 5 inhibitors in preventing cognitive impairment and Alzheimer pathology: A systematic review of animal studies
51/100 ✓ Peer-reviewed Disease mechanisms Behavioural brain research
Key finding: Cognitive decline in preclinical AD finds tauopathy has a more impact than Aβ-42. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-01
The relationship between sleep duration, cognition and dementia: a Mendelian randomization study
59/100 ✓ Peer-reviewed Long-term cohort studies International journal of epidemiology
Key finding: Linear MR suggested that each additional hour/day of sleep was associated with 1% [95% confidence interval (CI) = 0-2%; P = 0.008] slower reaction time and 3% more errors in visual-memory test (95% CI = 0-6%; P = 0.05). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-01
Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
51/100 ✓ Peer-reviewed TREM2 and immune genetics EMBO molecular medicine
Key finding: A number of variants in genes selectively expressed in microglia are associated with an increased risk for neurodegenerative diseases such as Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-01
Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes
63/100 ✓ Peer-reviewed Mild cognitive impairment Sleep
Key finding: Study objectives To determine the effect of self-reported clinical diagnosis of obstructive sleep apnea (OSA) on longitudinal changes in brain amyloid PET and CSF biomarkers (Aβ42, T-tau, and P-tau) in cognitively normal (NL), mild cognitive impairment (MCI), and Alzheimer's disease (AD) elderly. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-06-01
A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia
72/100 ✓ Peer-reviewed Caregiving Brain : a journal of neurology
Key finding: There was a statistically significant increase in the global estimate of cortical tau burden as measured by standardized uptake value ratio (SUVr) from baseline to 18 months in amyloid-β+ but not amyloid-β- subjects (least squared mean change in flortaucipir SUVr : 0.0524 ± 0.0085, P < 0.0001 and 0.0007 ± 0.0024 P = 0.7850, respectively), and a significant association between magnitude of SUVr increase and baseline tau burden. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-01
Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines
75/100 ✓ Peer-reviewed Prevention and risk Medicine and science in sports and exercise
Key finding: There is moderate-to-strong support that PA benefits cognitive functioning during early and late periods of the life span and in certain populations characterized by cognitive deficits. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-01
Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report
67/100 ✓ Peer-reviewed Prevention and risk Brain : a journal of neurology
Key finding: LATE-NC is a common TDP-43 proteinopathy, associated with an amnestic dementia syndrome that mimicked Alzheimer's-type dementia in retrospective autopsy studies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-06-01
CSF Beta-amyloid 1-42 Concentration Predicts Delirium Following Elective Arthroplasty Surgery in an Observational Cohort Study
59/100 ✓ Peer-reviewed Genetics Annals of surgery
Key finding: Delirium following surgery is common and associated with adverse outcomes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-06-01
Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype
65/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Estimates of AD disease duration become more accurate if age, sex, setting, APOE, and cerebrospinal fluid tau are taken into account. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-06-01
Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia
70/100 ✓ Peer-reviewed Biomarkers JAMA
Key finding: Analyses measured the associations between predictor variables and the memory score, and whether AT(N) biomarker profiles significantly improved prediction of memory z score rates of change beyond a model with clinical and genetic variables only. +2 more findings
Full summary, score breakdown and related studies → Original source
May 2019 3
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2019-05-31
Association Between Relevant Co-Morbidities and Dementia With Atrial Fibrillation-A National Study
55/100 ✓ Peer-reviewed Risk factors Archives of medical research
Key finding: Totally 30,332 patients (5.6%) were diagnosed with dementia during the follow-up, with 14,097 men (4.9%) and 16,235 women (6.5%). +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-05-31
Diagnosis of Alzheimer's Disease via Multi-Modality 3D Convolutional Neural Network
53/100 ✓ Peer-reviewed Digital health tools Frontiers in neuroscience
Key finding: Finally, the results have demonstrated that (1) segmentation is not a prerequisite when using a CNN for the classification, (2) the combination of two modality imaging data generates better results.
Full summary, score breakdown and related studies → Original source
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2019-05-31
Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions
48/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience
Key finding: Numerous population-based studies have suggested that early-life educational attainments and socioeconomic status, midlife work complexity and social engagements, late-life leisure activities (social, physical, and mentally-stimulating activities), certain personality traits (e.g., high neuroticism and low conscientiousness), and depression significantly affect late-life cognitive phenotypes.
Full summary, score breakdown and related studies → Original source
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