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[Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model.]
Vargas-Restrepo F, Sabogal-Guáqueta AM, Cardona-Gómez GP.. Biomedica : revista del Instituto Nacional de Salud, 2018-05-01
Topic: Brain proteins, microglia and lab models
Introduction Alzheimer's disease is the most common form of dementia. It is characterized by histopathological hallmarks such as senile plaques and neurofibrillary tangles, as well as a concomitant activation of microglial cells and astrocytes that release pro-inflammatory mediators such as IL-1β, iNOS, and COX-2, leading to neuronal dysfunction and death. Objective To evaluate the effect of quercetin on the inflammatory response in the CA1 area of the hippocampus in a 3xTg-AD male and female mice model. Materials and methods Animals were injected intraperitoneally with quercetin every 48 hours during three months, and we conducted histological and biochemical studies. Results We found that in quercetin-treated 3xTg-AD mice, reactive microglia and fluorescence intensity of Aβ aggregates significantly decreased. GFAP, iNOS, and COX-2 immunoreactivity also decreased and we observed a clear tendency in the reduction of IL-1β in hippocampal lysates. Conclusion Our work suggests an anti-inflammatory effect of quercetin in the CA1 hippocampal region of aged triple transgenic Alzheimer's disease mice.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Vargas-Restrepo, F., Sabogal-Guáqueta, A. M., & Cardona-Gómez, G. P. (2018). [Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model.]. Biomedica : revista del Instituto Nacional de Salud. https://doi.org/10.7705/biomedica.v38i0.3761
Vancouver
Vargas-Restrepo F, Sabogal-Guáqueta AM, Cardona-Gómez GP. [Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model.]. Biomedica : revista del Instituto Nacional de Salud. 2018. doi:10.7705/biomedica.v38i0.3761. PMID: 29809330.
BibTeX
@article{vargasrestrepo2018-29809330,
author = {Vargas-Restrepo, F. and Sabogal-Guáqueta, A. M. and Cardona-Gómez, G. P.},
title = {{[Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model.]}},
journal = {Biomedica : revista del Instituto Nacional de Salud},
year = {2018},
doi = {10.7705/biomedica.v38i0.3761},
pmid = {29809330},
url = {https://doi.org/10.7705/biomedica.v38i0.3761}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results We found that in quercetin-treated 3xTg-AD mice, reactive microglia and fluorescence intensity of Aβ aggregates significantly decreased.
- GFAP, iNOS, and COX-2 immunoreactivity also decreased and we observed a clear tendency in the reduction of IL-1β in hippocampal lysates.
Why it matters
In aged triple transgenic Alzheimer's disease mice, quercetin treatment reduced markers of inflammation and amyloid aggregates in one hippocampal region. This is animal research only and does not show that quercetin treats, cures, or prevents Alzheimer's disease in people.
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Study details
- Evidence strengthLow
How this study scored 33/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biomedica : revista del Instituto Nacional de Salud) |
| Journal's citation record | 0 / 4 | Biomédica: journal h-index 43 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “transgenic”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 36 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.6 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 2 / 6 | Cited 1.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 8 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Gloria Patricia Cardona‐Gómez: h-index 35 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universidad de Antioquia: institution h-index 298 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29809330) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 33 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.7705/biomedica.v38i0.3761
- PubMed: 29809330
- Original source →
- Free full text: revistabiomedica.org →
Full text: free to read — Unpaywall lists this copy as free to read: the link above (checked 10 Oct 2026).
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