Newest studies

How Do Scores on the ADAS-Cog, MMSE, and CDR-SOB Correspond?

49/100 ✓ Peer-reviewed Cognitive tests and assessment The Clinical neuropsychologist

Key finding: Clinicians and researchers who measure cognitive dysfunction often use the Alzheimer's Disease Assessment Scale--Cognitive Subscale (ADAS-Cog), the Mini-Mental State Examination (MMSE), or the Clinical Dementia Rating scale (CDR-SOB). +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

52/100 ✓ Peer-reviewed Risk genes beyond APOE Nature communications

Key finding: Defective DNA repair may contribute to neurological disorders, including Alzheimer's disease (AD). +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Nonpharmacological Interventions to Reduce Behavioral and Psychological Symptoms of Dementia: A Systematic Review

74/100 ✓ Peer-reviewed Clinical safety BioMed research international

Key finding: Studies are heterogeneous in many aspects, including size sample, intervention, and instruments of measures. +2 more findings

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The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials

69/100 ✓ Peer-reviewed Getting a diagnosis Ageing research reviews

Key finding: The primary analysis yielded a positive overall effect of physical activity interventions on cognitive function (SMD[95% confidence interval]=0.42[0.23;0.62], p<.01). +3 more findings

• Lifestyle
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Exendin-4 reduces tau hyperphosphorylation in type 2 diabetic rats via increasing brain insulin level

38/100 ✓ Peer-reviewed Drug development Molecular and cellular neurosciences

Key finding: We found that peripheral ex-4 injection in T2D rats reduced hyperphosphorylation of tau protein in rat hippocampus, probably via increasing hippocampal insulin which activated insulin signaling. +2 more findings

• Risk Factors

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Cerebrospinal Fluid Aβ40 Improves the Interpretation of Aβ42 Concentration for Diagnosing Alzheimer's Disease

47/100 ✓ Peer-reviewed Biomarkers Frontiers in neurology

Key finding: Previous studies showed significant heterogeneity in CSF Aβ42 levels to discriminate AD from non-AD patients. +1 more finding

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1

54/100 ✓ Peer-reviewed Risk genes beyond APOE Molecular neurobiology

Key finding: We performed the meta-analysis to obtain a more precise estimation of whether growth factor receptor-bound protein-associated binding protein 2 (GAB2), phosphatidylinositol binding clathrin assembly protein (PICALM), and sortilin-related receptor (SORL1) variants are associated with AD. +4 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

36/100 ✓ Peer-reviewed Disease mechanisms Pharmacology & therapeutics

Key finding: The gut microbiome comprises the collective genome of the trillions of microorganisms residing in our gastrointestinal ecosystem. +3 more findings

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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease

52/100 ✓ Peer-reviewed How common it is Mediators of inflammation

Key finding: As a cause or consequence, the chronic inflammatory response and oxidative stress associated with T2DM, amyloid-β (Aβ) protein accumulation, and mitochondrial dysfunction link T2DM and AD.

• Brain Biology
• Risk Factors

Full summary, score breakdown and related studies → Original source

Intensive care at the end of life in patients dying due to non-cancer chronic diseases versus cancer: a nationwide study in Denmark

52/100 ✓ Peer-reviewed End-of-life care Critical care (London, England)

Key finding: Overall, patients dying as a result of non-cancer diseases were twice as likely to be admitted to ICUs at the EOL as patients dying due to cancer. +4 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

From eyeless to neurological diseases

39/100 ✓ Peer-reviewed Brain scans and imaging Experimental eye research

Key finding: Age-related cataracts are frequently associated with degenerative changes in the ocular lens including the aggregation of proteins - mainly crystallins, but also other proteins including amyloids (Aβ) leading to the hypothesis that cataracts could be used as "biomarkers" for Alzheimer disease. +2 more findings

• Genetics

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Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study

47/100 ✓ Peer-reviewed Biomarkers EBioMedicine

Key finding: Plasma and CSF NFL concentrations were very highly correlated (r = 0.89, P < 0.0001).

• Biomarkers

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Neurotoxicity of traffic-related air pollution

38/100 ✓ Peer-reviewed Risk factors Neurotoxicology

Key finding: Human epidemiological studies and controlled animal studies have shown that exposure to air pollution, and to traffic-related air pollution or DE in particular, may lead to neurotoxicity.

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Do determinants of burden and emotional distress in dementia caregivers change over time?

70/100 ✓ Peer-reviewed Caregiving Aging & mental health

Key finding: General burden is shown to be determined by severity of patient's neuropsychiatric symptoms, caregiver's sense of competence, health-related quality of life. +2 more findings

• Caregiving

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Cerebrospinal fluid neurogranin and YKL-40 as biomarkers of Alzheimer's disease

59/100 ✓ Peer-reviewed Inflammation and the immune system Annals of clinical and translational neurology

Key finding: Widespread implementation of cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) in clinical settings requires improved accuracy for diagnosis of prodromal disease and for distinguishing AD from non-AD dementias. +3 more findings

• Biomarkers
• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Domain-specific versus generalized cognitive screening in acute stroke

61/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology

Key finding: The Oxford Cognitive Screen (OCS) provides a domain-specific cognitive profile designed for stroke survivors. +3 more findings

• Diagnosis

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Cascading network failure across the Alzheimer's disease spectrum

52/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology

Key finding: The two main findings of this paper are (i) the posterior default mode network fails before measurable amyloid plaques and appears to initiate a connectivity cascade that continues throughout the disease spectrum; and (ii) high connectivity between the posterior default mode network and hubs of high connectivity (many located in the frontal lobe) is associated with amyloid accumulation. +1 more finding

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Cerebral Vasoreactivity, Apolipoprotein E, and the Risk of Dementia: A Population-Based Study

58/100 ✓ Peer-reviewed Long-term cohort studies Arteriosclerosis, thrombosis, and vascular biology

Key finding: Cerebral vasoreactivity (CVR) is a key factor in maintenance of continuous cerebral perfusion and a marker of (micro)vascular damage. +3 more findings

• Risk Factors

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Aging in Taiwan: Building a Society for Active Aging and Aging in Place

38/100 ✓ Peer-reviewed Disparities The Gerontologist

Key finding: Taiwan's accelerated rate of aging is more than twice that of European countries and United States. +4 more findings

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Visual Versus Fully Automated Analyses of 18F-FDG and Amyloid PET for Prediction of Dementia Due to Alzheimer Disease in Mild Cognitive Impairment

38/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Both (18)F-FDG and (11)C-PiB imaging appear to be of limited use for predicting the progression from MCI to dementia due to AD in short-term follow-up, irrespective of the strategy of analysis. +2 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

47/100 ✓ Peer-reviewed Inflammation and the immune system Journal of neurochemistry

Key finding: Deposition of amyloid-β (Aβ) remains a hallmark feature of the disease, yet the precise mechanism(s) by which this peptide induces neurotoxicity remain unknown. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Pomegranate's Neuroprotective Effects against Alzheimer's Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites

36/100 ✓ Peer-reviewed Disease mechanisms ACS chemical neuroscience

Key finding: In silico computational studies, used to predict blood-brain barrier permeability, revealed that none of the PE constituents, but the urolithins, fulfilled criteria required for penetration.

• Brain Biology

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A systematic review of reasons for gatekeeping in palliative care research

64/100 ✓ Peer-reviewed End-of-life care Palliative medicine

Key finding: Gatekeeping is motivated by the general assumption of vulnerability of patients, coupled with an emphasis on the duty to protect patients.

• End-of-Life Care

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Group and individual cognitive therapies in Alzheimer's disease: the ETNA3 randomized trial

69/100 ✓ Peer-reviewed Prevention trials International psychogeriatrics

Key finding: These findings challenge current management practices of Alzheimer's patients. +3 more findings

• Clinical Trials
• Treatments

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The Burden of Health Care Costs for Patients With Dementia in the Last 5 Years of Life

66/100 ✓ Peer-reviewed Costs and economics Annals of Internal Medicine

Key finding: Average total cost per dementia decedent was $287,038 over the last 5 years of life, higher than for heart disease, cancer, or other causes +3 more findings

• Policy

Full summary, score breakdown and related studies → Original source