Newest studies

Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis

47/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Frontiers in aging neuroscience

Key finding: In this review, we describe metabolic and vascular neuroimaging studies in DS that suggest these functional changes are a key feature of aging, linked to cognitive decline and AD in this vulnerable cohort. +4 more findings

• Brain Scans
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?

39/100 ✓ Peer-reviewed TREM2 and immune genetics Expert opinion on therapeutic targets

Key finding: Expert opinion: Studies suggest TREM2 plays a key role in AD pathology; however, results have been conflicting about whether TREM2 is beneficial or harmful.

• Genetics
• Treatments

Full summary, score breakdown and related studies → Original source

Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathology

38/100 ✓ Peer-reviewed Risk factors Environmental research

Key finding: The present study demonstrates that chronic exposure to high levels of air pollution results in AD- and PD-related pathology within the olfactory bulbs of children and relatively young adults ages 11 months to 40 years. +3 more findings

• Risk Factors
• Brain Biology

Full summary, score breakdown and related studies → Original source

Drug development for Alzheimer's disease: review

38/100 ✓ Peer-reviewed Drug development Journal of drug targeting

Key finding: Novel techniques and strategies are desperately needed to significantly accelerate this process.

• Treatments

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Barriers and facilitators for GPs in dementia advance care planning: A systematic integrative review

62/100 ✓ Peer-reviewed End-of-life care PloS one

Key finding: Discussing future care is difficult due to uncertainties about the future and the decisional capacities of people with dementia.

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk

36/100 ✓ Peer-reviewed Tau biomarkers Science translational medicine

Key finding: TREM2 plays a critical role in microglial activation, survival, and phagocytosis; however, the pathophysiological role of sTREM2 in AD is not well understood. +3 more findings

• Genetics
• Biomarkers

Full summary, score breakdown and related studies → Original source

No association of salivary total tau concentration with Alzheimer's disease

47/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging

Key finding: Saliva is a rich source of potential biomarkers and proteins related to neurodegenerative disorders have been shown to be present in this matrix, including tau. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Benzofuran and Indole: Promising Scaffolds for Drug Development in Alzheimer's Disease

39/100 ✓ Peer-reviewed Treatments ChemMedChem

Key finding: Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically accepted treatment to cure or halt its progression. +3 more findings

• Treatments

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Classification of Alzheimer's Disease by Combination of Convolutional and Recurrent Neural Networks Using FDG-PET Images

53/100 ✓ Peer-reviewed Digital health tools Frontiers in neuroinformatics

Key finding: Experimental results show that the proposed method achieves an area under receiver operating characteristic curve (AUC) of 95.3% for AD vs.

• Brain Scans
• Digital Tools

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Comparative efficacy and acceptability of antidiabetic agents for Alzheimer's disease and mild cognitive impairment: A systematic review and network meta-analysis

76/100 ✓ Peer-reviewed Drug development Diabetes, obesity & metabolism

Key finding: The results of 29 pairwise comparisons indicated that cognition was significantly improved in subjects treated with antidiabetic agents compared with placebo. +2 more findings

• Treatments
• Early Stage

Full summary, score breakdown and related studies → Original source

Comparison of Computerized and Paper-and-Pencil Memory Tests in Detection of Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-analysis of Diagnostic Studies

71/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Medical Directors Association

Key finding: Both verbal and visual computerized memory tests showed comparable diagnostic performance to the paper-and-pencil tests.

• Diagnosis
• Early Stage
• Digital Tools

Full summary, score breakdown and related studies → Original source

Donepezil for dementia due to Alzheimer's disease

79/100 ✓ Peer-reviewed Treatments The Cochrane database of systematic reviews

Key finding: Alzheimer's disease is the most common cause of dementia in older people. +3 more findings

• Treatments

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Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018

38/100 ✓ Peer-reviewed Clinical safety British journal of anaesthesia

Key finding: A multispecialty working group followed a modified Delphi procedure with no prespecified number of rounds comprised of three face-to-face meetings followed by online editing of draft versions. +4 more findings

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Road traffic noise, air pollution, and risk of dementia - results from the Betula project

69/100 ✓ Peer-reviewed Risk factors Environmental research

Key finding: We found no evidence that exposure to road traffic noise, either independently or in combination with traffic air pollution, was associated with risk of dementia in our study area. +4 more findings

• Risk Factors

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Raman Spectroscopy to Diagnose Alzheimer's Disease and Dementia with Lewy Bodies in Blood

41/100 ✓ Peer-reviewed Biomarkers ACS chemical neuroscience

Key finding: G-score values were also estimated between 74% and 91%, demonstrating that the overall performance of the classification model was satisfactory. +1 more finding

• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source

Quantification of [18F]florbetapir: A test-retest tracer kinetic modelling study

39/100 ✓ Peer-reviewed Brain scans and imaging Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Key finding: Compared to controls, Alzheimer's disease patients had lower MMSE scores and evidence for cortical Aβ pathology.

Full summary, score breakdown and related studies → Original source

Association between air pollution from residential wood burning and dementia incidence in a longitudinal study in Northern Sweden

57/100 ✓ Peer-reviewed Risk factors PloS one

Key finding: If the associations we observed are causal, then air pollution from residential wood burning, and air pollution from traffic, might be independent important risk factors for dementia. +2 more findings

• Risk Factors

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Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE

79/100 ✓ Peer-reviewed Genetics International journal of obesity (2005)

Key finding: These results provide new insight into the genetic basis of habitual PA, and the genetic links connecting PA with other traits and diseases. +4 more findings

• Genetics
• Lifestyle

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Increased CAIDE dementia risk, cognition, CSF biomarkers, and vascular burden in healthy adults

48/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Cognitively normal participants (mean age 57.6 years) from the Gipuzkoa Alzheimer Project study were classified as having high risk (HR; n = 82) or low risk (LR; n = 293) for dementia according to a CAIDE score cutoff of 9. +3 more findings

• Biomarkers
• Risk Factors

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Machine-learning based identification of undiagnosed dementia in primary care: a feasibility study

56/100 ✓ Peer-reviewed Digital health tools BJGP open

Key finding: The results show that routinely collected primary care data may be used to identify undiagnosed dementia. +2 more findings

• Care Services

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CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity

39/100 ✓ Peer-reviewed Disease mechanisms Cell reports

Key finding: In this study, we show that oAβ promotes the activation of Ca2+/calmodulin-dependent kinase II (CaMKII) via GluN2B-containing NMDARs. +4 more findings

• Brain Biology

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Internet-Based Interventions Aimed at Supporting Family Caregivers of People With Dementia: Systematic Review

70/100 ✓ Peer-reviewed Caregiving Journal of medical Internet research

Key finding: Although mixed, the results indicate a positive response for the use of internet-based interventions by caregivers. +3 more findings

• Caregiving

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Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

47/100 ✓ Peer-reviewed Drug development Nature medicine

Key finding: We found that NLY01 is a potent GLP1R agonist with favorable properties that is neuroprotective through the direct prevention of microglial-mediated conversion of astrocytes to an A1 neurotoxic phenotype.

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Brain age and other bodily 'ages': implications for neuropsychiatry

45/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: Some of these techniques, using statistical approaches, have the ability to predict chronological age in healthy people. +4 more findings

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Abnormal gut microbiota composition contributes to cognitive dysfunction in SAMP8 mice

41/100 ✓ Peer-reviewed Disease mechanisms Aging

Key finding: The cognitive function in senescence-accelerated mouse prone 8 (SAMP8) mice was significantly decreased and the Chao 1 and Shannon indices, principal coordinates analysis, and principal component analysis results were notably abnormal compared with that of those in senescence-accelerated mouse resistant 1 (SAMR1) mice. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source