Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 14,276–14,300 of 27,380 studies, newest first · page 572 of 1096.
February 2018 16
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2018-02 month only
Lack of association between triggering receptor expressed on myeloid cells 2 polymorphism rs75932628 and late-onset Alzheimer's disease in a Chinese Han population
52/100 ✓ Peer-reviewed TREM2 and immune genetics Psychiatric genetics
Key finding: Our aim was to investigate the link between the TREM2 polymorphism and LOAD in the Chinese Han population. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
The relationship between stress and Alzheimer's disease
41/100 ✓ Peer-reviewed Health systems and care delivery Neurobiology of stress
Key finding: This is becoming increasingly clear in the case of neurodegenerative diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease
38/100 ✓ Peer-reviewed Drug development ACS nano
Key finding: Recent studies have shown that the tau pathway is closely associated with clinical development of AD symptoms, which might be a potential therapeutic target. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Networks of tau distribution in Alzheimer's disease
48/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: Second, to investigate if regions of high tau burden are associated with functional connectivity networks, we extracted the region with the maximum z-value in each of the generated tau pathology networks and used them as seeds in a subsequent resting-state functional MRI analysis, conducted in a group of healthy adults (n = 26) who were part of the 1000 Functional Connectomes Project. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach
45/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology
Key finding: Levels of 25 synaptic proteins were significantly altered in the various dementia groups. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration
72/100 ✓ Peer-reviewed Inflammation and the immune system Brain : a journal of neurology
Key finding: Traumatic brain injury triggers chronic microglial activation, but it is unclear whether this is harmful or beneficial. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
51/100 ✓ Peer-reviewed Inflammation and the immune system Biomedical journal
Key finding: In 2016, nearly 44 million people were affected by AD or related dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Traumatic brain injury history is associated with an earlier age of dementia onset in autopsy-confirmed Alzheimer's disease
51/100 ✓ Peer-reviewed Long-term cohort studies Neuropsychology
Key finding: Data from 2,133 participants with autopsy-confirmed AD (i.e., at least Braak neurofibrillary tangle stages III to VI and CERAD neuritic plaque score moderate to frequent) were obtained from the National Alzheimer's Coordinating Center (NACC). +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model
58/100 ✓ Peer-reviewed TREM2 and immune genetics Brain : a journal of neurology
Key finding: We examined post-mortem brains from teenage athletes in the acute-subacute period after mild closed-head impact injury and found astrocytosis, myelinated axonopathy, microvascular injury, perivascular neuroinflammation, and phosphorylated tau protein pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Neutrophil hyperactivation correlates with Alzheimer's disease progression
55/100 ✓ Peer-reviewed Mild cognitive impairment Annals of neurology
Key finding: Our results indicate that the inflammatory properties of circulating neutrophils shift as the percentage of aged neutrophils expands in patients with AD-changes that may play an instrumental role in establishing systemic chronic inflammation. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment
51/100 ✓ Peer-reviewed Lewy body dementia Cell
Key finding: Here, we address the elusive link between these phenomena by employing cryo-electron tomography to dissect the molecular architecture of protein aggregates within intact neurons at high resolution. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models
41/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Key finding: In vivo 11 C-PBB3 binding to the rTg4510 neocortex/hippocampus was increased relative to controls and correlated with local atrophy. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease
56/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology
Key finding: These findings suggest that patterns of cortical Aβ and tau do not differ in people with PD-CN, people with PD-MCI, and healthy older adults. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study
77/100 ✓ Peer-reviewed Brain scans and imaging The Lancet. Neurology
Key finding: We found a sequence to pathological changes, with rates of Aβ deposition in mutation carriers being significantly different from those in non-carriers first (across regions that showed a significant difference, at a mean of 18·9 years [SD 3·3] before expected onset), followed by hypometabolism (14·1 years [5·1] before expected onset), and lastly structural decline (4·7 years [4·2] before expected onset). +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-02-01
Proton Pump Inhibitors: Review of Emerging Concerns
46/100 ✓ Peer-reviewed Prevention and risk Mayo Clinic proceedings
Key finding: PPIs inhibit gastric acid secretion, and the most commonly associated adverse effects include abdominal pain, diarrhea, and headache. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-02-01
Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis
71/100 ✓ Peer-reviewed Prevention and risk JAMA otolaryngology-- head & neck surgery
Key finding: Forty studies from 12 countries met our inclusion criteria. +4 more findings
Full summary, score breakdown and related studies → Original source
January 2018 9
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2018-01-31
Heterogeneous patterns of brain atrophy in Alzheimer's disease
41/100 ✓ Peer-reviewed Digital health tools Neurobiology of aging
Key finding: There is increasing evidence showing that brain atrophy varies between patients with Alzheimer's disease (AD), suggesting that different anatomical patterns might exist within the same disorder. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-31
Parkinson's disease from the gut
38/100 ✓ Peer-reviewed Disease mechanisms Brain research
Key finding: Parkinson's disease (PD) is a debilitating neurodegenerative condition associated with tremor, rigidity, dementia, and gastrointestinal symptoms such as constipation, nausea and vomiting. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-31
Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models
38/100 ✓ Peer-reviewed Drug development Neuropharmacology
Key finding: Based on these results, several clinical trials have shown first encouraging effects in patients with Alzheimer's or Parkinson' disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-01-31
Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice
41/100 ✓ Peer-reviewed Drug development Alzheimer's research & therapy
Key finding: These findings indicate that AD p-Tau-injected 3 × Tg-AD mice represent a practical model to study the seeding and spread of Tau pathology, their effect on Aβ pathology, and the effect of Tau immunotherapy on both Tau and Aβ pathologies. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-31
High performance plasma amyloid-β biomarkers for Alzheimer’s disease
60/100 ✓ Peer-reviewed Biomarkers Nature
Key finding: All test biomarkers showed high performance when predicting brain amyloid-β burden. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-31
Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis
69/100 ✓ Peer-reviewed Risk genes beyond APOE Neurology
Key finding: We systematically searched PubMed for eligible studies reporting data on CSF biomarkers reflecting amyloid precursor protein metabolism (Aβ42, Aβ40), neurodegeneration (t-tau), and tangle pathology (p-tau) in symptomatic sporadic CAA cohorts vs controls and patients with Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-31
Oxidant/Antioxidant Imbalance in Alzheimer's Disease: Therapeutic and Diagnostic Prospects
45/100 ✓ Peer-reviewed Caregiving Oxidative medicine and cellular longevity
Key finding: Alzheimer's disease (AD) is the most common cause of dementia and a great socioeconomic burden in the aging society. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-30
Mobility and cognition at admission to the nursing home - a cross-sectional study
52/100 ✓ Peer-reviewed Health systems and care delivery BMC geriatrics
Key finding: Forty-three percent of the residents were not able to perform the balance test in SPPB. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-30
The effects of an 8-week computerized cognitive training program in older adults: a study protocol for a randomized controlled trial
74/100 ✓ Peer-reviewed Prevention trials BMC geriatrics
Key finding: If results from this study show benefits for cognition at trial completion, CCT programs, alone or in combination with walking, might be a strategy to promote healthy cognitive aging in older adults. +2 more findings
Full summary, score breakdown and related studies → Original source
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