Newest studies

Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits

41/100 ✓ Peer-reviewed Drug development Aging cell

Key finding: In contrast, while growing evidence suggests that tau is also involved in synaptic physiology, a complete assessment of tau function in the adult brain has been hampered by robust developmental compensation of other microtubule-binding proteins in tau knockout mice. +3 more findings

• Brain Biology

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TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling

45/100 ✓ Peer-reviewed TREM2 and immune genetics Cell biology international

Key finding: TREM2 expression or TREM2-specific siRNA were used to induce TREM2 overexpression or silencing. +3 more findings

• Brain Biology
• Genetics

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Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease

54/100 ✓ Peer-reviewed Mild cognitive impairment Scientific reports

Key finding: Among MCI due to AD subjects, the mean worsening in cognitive score was significantly greater in females (11.58 ± 14) than in males (6.87 ± 11, p = 0.006). +1 more finding

• Early Stage

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Genome-wide association study identifies two loci influencing plasma neurofilament light levels

49/100 ✓ Peer-reviewed Biomarkers BMC medical genomics

Key finding: GWAS found the associations of two single nucleotide polymorphisms (rs7943454 and rs640476) with plasma NFL at suggestive levels. +4 more findings

• Biomarkers
• Genetics
• Early Stage

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Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials

54/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: These results support the feasibility of bridging of clinical trials in the prodromal stage of AD between Asia and western countries. +2 more findings

• Early Stage

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Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

60/100 ✓ Peer-reviewed Lewy body dementia Nature

Key finding: GCI-α-Syn and LB-α-Syn show no cell-type preference in seeding α-Syn pathology, which raises the question of why they demonstrate different cell-type distributions in Lewy body disease versus multiple system atrophy. +1 more finding

• Other Dementias

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External validation of four dementia prediction models for use in the general community-dwelling population: a comparative analysis from the Rotterdam Study

67/100 ✓ Peer-reviewed Long-term cohort studies European journal of epidemiology

Key finding: We selected four prediction models for validation: CAIDE, BDSI, ANU-ADRI and DRS. +3 more findings

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The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

57/100 ✓ Peer-reviewed TREM2 and immune genetics Immunity

Key finding: Microglial defects in phagocytosis of toxic aggregates or apoptotic membranes were proposed to be at the origin of the pathological processes in the presence of Trem2 inactivating mutations. +3 more findings

• Genetics
• Brain Biology

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Living well with dementia: a systematic review and correlational meta-analysis of factors associated with quality of life, well-being and life satisfaction in people with dementia

71/100 ✓ Peer-reviewed Caregiving Psychological medicine

Key finding: We searched electronic databases until 7 January 2016 for observational studies investigating factors associated with QoL, well-being and life satisfaction in people with dementia. +3 more findings

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A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia

59/100 ✓ Peer-reviewed Treatments Dementia and geriatric cognitive disorders

Key finding: Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. +3 more findings

• Treatments

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Delirium as a predictor of mortality in US Medicare beneficiaries discharged from the emergency department: a national claims-level analysis up to 12 months

67/100 ✓ Peer-reviewed End-of-life care BMJ open

Key finding: Our results demonstrate delirium is a significant marker of mortality among seniors in the ED, and mortality risk is most salient in the first 3 months following an ED visit. +4 more findings

• Policy
• Care Services

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Age-Related Hearing Loss: Innovations in Hearing Augmentation

39/100 ✓ Peer-reviewed Risk factors Otolaryngologic clinics of North America

Key finding: Age-related hearing loss is a multifactorial condition that affects more than one-third of the aging population. +4 more findings

• Risk Factors

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Blood Ammonia as a Possible Etiological Agent for Alzheimer's Disease

41/100 ✓ Peer-reviewed Prevention trials Nutrients

Key finding: Extracellular accumulation of beta-amyloid peptide (Aβ) and intracellular accumulation of tau undeniably play essential roles in the etiology of AD. +4 more findings

• Treatments

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Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects

47/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: In younger controls, SUV peak was observed in the temporal lobe with values of approximately 3.0 for 11 C-RO-963, 1.5 for 11 C-RO-643, and 3.5 for 18 F-RO-948. +4 more findings

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Self-Compassion, Coping Strategies, and Caregiver Burden in Caregivers of People with Dementia

46/100 ✓ Peer-reviewed Caregiving Clinical gerontologist

Key finding: Self-compassion was found to be negatively related to caregiver burden and dysfunctional coping strategies and positively related to emotion-focused coping strategies. +3 more findings

• Caregiving

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Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies

39/100 ✓ Peer-reviewed Brain scans and imaging Dementia and geriatric cognitive disorders

Key finding: While the DLB patients scored well and did not differ from the control and AD groups in terms of functional activity and connectivity during the task conditions, they showed decreased functional connectivity in visuoperceptual regions during the resting state condition, along with a temporal impairment of the default-mode network activity. +3 more findings

• Other Dementias

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Meta-Analysis of the Effects of Computerized Cognitive Training on Executive Functions: a Cross-Disciplinary Taxonomy for Classifying Outcome Cognitive Factors

66/100 ✓ Peer-reviewed Prevention trials Neuropsychology review

Key finding: The growing prevalence of neurodegenerative disorders associated with aging and cognitive decline has generated increasing cross-disciplinary interest in non-pharmacological interventions, such as computerized cognitive training (CCT), which may prevent or slow cognitive decline. +1 more finding

• Lifestyle
• Digital Tools

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Health management and pattern analysis of daily living activities of people with dementia using in-home sensors and machine learning techniques

47/100 ✓ Peer-reviewed Digital health tools PloS one

Key finding: The algorithms are developed with different temporal granularity to process the data for long-term and short-term analysis. +4 more findings

• Digital Tools

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Alzheimer's disease drug development pipeline: 2018

54/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's & dementia (New York, N. Y.)

Key finding: The AD drug development pipeline is slightly larger in 2018 than in 2017. +1 more finding

• Treatments

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Development of comorbidities in men with prostate cancer treated with androgen deprivation therapy: an Australian population-based cohort study

53/100 ✓ Peer-reviewed Digital health tools Prostate cancer and prostatic diseases

Key finding: Men with prostate cancer treated with androgen deprivation therapy had a higher likelihood of developing new comorbidities than men who did not receive androgen deprivation therapy. +2 more findings

• Treatments
• Risk Factors

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Mortality and hospitalization at the end of life in newly admitted nursing home residents with and without dementia

57/100 ✓ Peer-reviewed Digital health tools Social psychiatry and psychiatric epidemiology

Key finding: A high proportion of residents with and without dementia are hospitalized shortly before death. +1 more finding

• Care Services
• End-of-Life Care

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PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer's disease

41/100 ✓ Peer-reviewed Risk factors Journal of neuroinflammation

Key finding: For the first time, these results suggested that the effects of PM2.5 under AD context were possibly mediated by NLRP3 inflammasome activation, which was triggered by ROS. +3 more findings

• Brain Biology
• Risk Factors

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Disparities in Nursing Home Use and Quality Among African American, Hispanic, and White Medicare Residents With Alzheimer’s Disease and Related Dementias

49/100 ✓ Peer-reviewed Health systems and care delivery Journal of Aging and Health

Key finding: We found that a larger share of Hispanic Medicare residents that are admitted to nursing homes have ADRD compared with African American and White beneficiaries. +2 more findings

• Health Equity
• Care Services
• Policy

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SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment

39/100 ✓ Peer-reviewed Disease mechanisms Cell death & disease

Key finding: The function of SMPD3 has remained elusive. +4 more findings

• Brain Biology

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Ambient ozone exposure and mental health: A systematic review of epidemiological studies

66/100 ✓ Peer-reviewed Risk factors Environmental research

Key finding: Current evidence for an association between ambient ozone exposure and mental health outcomes is inconclusive and further high quality studies are needed to assess any potential links given the strong biologic plausibility. +1 more finding

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