Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,526–26,550 of 27,380 studies, newest first · page 1062 of 1096.
May 1995 11
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1995-05-01
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
36/100 ✓ Peer-reviewed Risk genes beyond APOE Cell
Key finding: Neurological evaluation showed that the APP-deficient mice exhibited a decreased locomotor activity and forelimb grip strength, indicating a compromised neuronal or muscular function. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-05-01
Seasonal variation in hippocampal volume in a food-storing bird, the black-capped chickadee
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Journal of neurobiology
Key finding: We found that the hippocampal formation, which is involved in spatial memory for cached food items, has a larger volume, relative to the rest of the brain, in October than at any other time of the year. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-05-01
Alzheimer and vascular dementias and driving. A prospective road and laboratory study
41/100 ✓ Peer-reviewed Clinical safety JAMA
Key finding: Based on this study, type and degree of cognitive impairment are better predictors of driving skills than age or medical diagnosis per se. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-05-01
A randomized trial of comprehensive geriatric assessment in the care of hospitalized patients
61/100 ✓ Peer-reviewed Clinical safety The New England journal of medicine
Key finding: In this HMO, comprehensive geriatric assessment by a consultation team, with limited follow-up, did not improve the health or survival of hospitalized patients selected on the basis of screening criteria.
Full summary, score breakdown and related studies → Original source
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1995-05-01
Correlations of synaptic and pathological markers with cognition of the elderly
36/100 ✓ Peer-reviewed Clinical safety Neurobiology of aging
Key finding: It has been suggested that the physical basis for dementia is structural or functional loss of synapses. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-05-01
Staging of alzheimer's disease-related neurofibrillary changes
48/100 ✓ Peer-reviewed Brain tissue and pathology Neurobiology of Aging
Key finding: Specific immunocytochemical methods (AT8) permit evaluation of neuronal changes well before the actual formation of neurofibrillary tangles and neuropil threads. +2 more findings
Full summary, score breakdown and related studies → Original source
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1995-05-01
Memory disorders in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI
49/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of neurology, neurosurgery, and psychiatry
Key finding: Neuropsychological examination included the mini mental state examination (MMSE), the Mattis dementia rating scale (DRS), tests of executive functions, assessment of language abilities and praxis, the Wechsler memory scale (WMS), the California verbal learning test (CVLT) and the Grober and Buschke test. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-05-01
Detection of Alzheimer disease in individuals with Down syndrome
34/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of mental retardation : AJMR
Key finding: A comprehensive baseline of emotional functioning was established for adults with Down syndrome. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-05-01
A population-based assessment of the impact and burden of caregiving for long-term stroke survivors
48/100 ✓ Peer-reviewed Caregiving Stroke
Key finding: In this population, the high level of emotional distress among caregivers of stroke patients suggests that many caregivers have unmet needs. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-05-01
The 'preclinical phase' of probable Alzheimer's disease. A 13-year prospective study of the Framingham cohort
60/100 ✓ Peer-reviewed Getting a diagnosis Archives of neurology
Key finding: These findings support previous contentions that a "preclinical phase" of detectable cognitive deficits can precede the clinical diagnosis of probable AD by many years, and they also support the hypothesis that problems with secondary verbal memory are among the first signs of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-05-01
Apolipoprotein E and Alzheimer disease
50/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: The mechanism by which the apoE isoforms differentially contribute to disease expression is, however, unknown. +4 more findings
Full summary, score breakdown and related studies → Original source
April 1995 13
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1995-04 month only
Transitions in long-term care
38/100 ✓ Peer-reviewed Health systems and care delivery The Gerontologist
Key finding: Discrete-time hazard functions were estimated to determine factors associated with the probability of these transitions. +2 more findings
Full summary, score breakdown and related studies → Original source
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1995-04-01
Role of glucose in regulating the brain and cognition
36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's The American journal of clinical nutrition
Key finding: Extensive evidence indicates that relatively modest increases in circulating glucose concentrations enhance learning and memory processes in rodents and humans. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-04-01
Activation of microglial cells by beta-amyloid protein and interferon-gamma
41/100 ✓ Peer-reviewed Inflammation and the immune system Nature
Key finding: These findings suggest that A beta and IFN-gamma activate microglia to produce reactive nitrogen intermediates and TNF-alpha, and this may have a role in the pathogenesis of neuronal degeneration observed in ageing and Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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1995-04-01
Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons
40/100 ✓ Peer-reviewed Drug development The Journal of cell biology
Key finding: In addition, we demonstrated that beta PP from distal axons was transcytotically transported to the surface of perikarya from distal axons in sympathetic neurons. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-04-01
Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205
36/100 ✓ Peer-reviewed Drug development Neuroscience letters
Key finding: Hyperphosphorylated microtubule-associated protein tau is the major component of the paired helical filament of Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-04-01
Methods for normalization of hippocampal volumes measured with MR
43/100 ✓ Peer-reviewed Hippocampus size on brain scans AJNR. American journal of neuroradiology
Key finding: Correction processes can define absolute hippocampal volumes for correlation studies and may enable identification of unsuspected bilateral hippocampal volume loss.
Full summary, score breakdown and related studies → Original source
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1995-04-01
The naturalness of dying
41/100 ✓ Peer-reviewed End-of-life care JAMA
Key finding: We prefer instead to believe that dying results from disease and injury, which may yield to advances in medical technology. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-04-01
Mechanisms of synaptic dysfunction in Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Histology and histopathology
Key finding: It is believed that these brain alterations are associated with abnormal expression and/or processing of amyloid precursor protein (APP) and with abnormal assembly of cytoskeletal proteins. +4 more findings
Full summary, score breakdown and related studies → Original source
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1995-04-01
Central auditory processing in Alzheimer's disease
34/100 ✓ Peer-reviewed Digital health tools Ear and hearing
Key finding: Peripheral auditory status was statistically similar between subject groups. +4 more findings
Full summary, score breakdown and related studies → Original source
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1995-04-01
Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study
62/100 ✓ Peer-reviewed How common it is BMJ (Clinical research ed.)
Key finding: The prevalence of dementia increases exponentially with age.
Full summary, score breakdown and related studies → Original source
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1995-04-01
Item bias in cognitive screening measures: comparisons of elderly white, Afro-American, Hispanic and high and low education subgroups
43/100 ✓ Peer-reviewed Disparities Journal of clinical epidemiology
Key finding: A study of item bias in standard cognitive screening measures was conducted in a sample of Afro-American, Hispanic and non-Hispanic white elderly respondents who were part of a dementia case registry study. +3 more findings
Full summary, score breakdown and related studies → Original source
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1995-04-01
Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals
68/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: These data suggest the following: (1) patients with mild cognitive impairment can be clinically defined, (2) many members of this group progress to Alzheimer's disease, and (3) APOE epsilon 4 allele status appears to be a strong predictor of clinical progression. +1 more finding
Full summary, score breakdown and related studies → Original source
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1995-04-01
Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome)
46/100 ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America
Key finding: It has long been recognized that another genetic abnormality, trisomy 21 (Down syndrome), is associated with early and severe development of AD neuropathological lesions. +2 more findings
Full summary, score breakdown and related studies → Original source
March 1995 1
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1995-03 month only
Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population
38/100 ✓ Peer-reviewed Genetics Brain research. Molecular brain research
Key finding: In ApoE4/4 brains, the SP formation was significantly higher. +1 more finding
Full summary, score breakdown and related studies → Original source
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