Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 14,651–14,675 of 27,380 studies, newest first · page 587 of 1096.
October 2017 25
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2017-10-20
Improving Care Through Public Policy
28/100 ✓ Peer-reviewed Risk factors The Gerontologist
Key finding: As has been noted, Alzheimer’s and related dementias are underdiagnosed and when diagnoses are made, they are too often undisclosed by clinicians: studies suggest that fewer than half of individuals report being told of their diagnoses (Alzheimer’s Association, 2015). +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-20
Cognitive Frailty in China: Results from China Comprehensive Geriatric Assessment Study
52/100 ✓ Peer-reviewed Disparities Frontiers in medicine
Key finding: Our results provide the first empirical evidence of CF in China. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-19
Neural basis of major depressive disorder: Beyond monoamine hypothesis
38/100 ✓ Peer-reviewed Hippocampus size on brain scans Psychiatry and clinical neurosciences
Key finding: Past studies have revealed that the volume of the hippocampus is decreased in patients with MDD, which is likely caused by the failure of the hypothalamic-pituitary-adrenal axis and following elevation of glucocorticoids.
Full summary, score breakdown and related studies → Original source
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2017-10-19
Gut microbiome alterations in Alzheimer's disease
59/100 ✓ Peer-reviewed Getting a diagnosis Scientific reports
Key finding: Recent studies in rodents suggest that alterations in the gut microbiome may contribute to amyloid deposition, yet the microbial communities associated with AD have not been characterized in humans. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-19
Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial
77/100 ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-18
Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia
39/100 ✓ Peer-reviewed TREM2 and immune genetics Mediators of inflammation
Key finding: We showed that lipopolysaccharide (LPS) stimulation significantly increases proinflammatory cytokines and suppressed TREM2 in microglia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-18
Oxidative stress and the amyloid beta peptide in Alzheimer's disease
41/100 ✓ Peer-reviewed Disease mechanisms Redox biology
Key finding: Histopathological hallmarks of AD are intracellular neurofibrillary tangles and extracellular formation of senile plaques composed of the amyloid-beta peptide (Aβ) in aggregated form along with metal-ions such as copper, iron or zinc. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-18
Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer's disease
41/100 ✓ Peer-reviewed Disease mechanisms Scientific reports
Key finding: It has previously been shown that the consumption of probiotics may have beneficial effects not only on peripheral tissues but also on the central nervous system and behavior via the microbiota-gut-brain axis, raising the possibility that treatment with probiotics could be an effective therapeutic strategy for managing neurodegenerative disorders. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-18
In vivo staging of regional amyloid deposition
70/100 ✓ Peer-reviewed How common it is Neurology
Key finding: The highly consistent regional hierarchy of PET-evidenced amyloid deposition across participants resembles neuropathologic observations and suggests a predictable regional sequence that may be used to stage an individual's progress of amyloid pathology in vivo. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-10-17
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
39/100 ✓ Peer-reviewed Disease mechanisms Current neurology and neuroscience reports
Key finding: The purposes of this review were as follows: first, to provide an overview of the gut microbiota and its interactions with the gut and the central nervous system (the microbiota-gut-brain axis) in health, second, to review the relevance of this axis to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease, and, finally, to assess the potential for microbiota-targeted therapies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-17
Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
45/100 ✓ Peer-reviewed Drug development Nature communications
Key finding: Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and associated with the development of chronic traumatic encephalopathy (CTE) and Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-17
Can we predict your future? Using scores to predict length of stay and discharge destination
32/100 ✓ Peer-reviewed Health systems and care delivery International Journal of Integrated Care
Key finding: 120 patients were included in the audit with a confirmed stroke on CTB/MRI. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-16
The potential of solanezumab and gantenerumab to prevent Alzheimer's disease in people with inherited mutations that cause its early onset
39/100 ✓ Peer-reviewed Treatments Expert opinion on biological therapy
Key finding: The recent failure of several clinical trials on anti-β-amyloid (Aβ) drugs in Alzheimer's disease (AD) suggested earlier intervention in the disease course. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-16
Considerations and code for partial volume correcting [ 18 F]-AV-1451 tau PET data
41/100 ✓ Peer-reviewed Brain scans and imaging Data in brief
Key finding: PET signal unlikely to be associated with tau also occurs in skull, meninges and soft tissue (see e.g. [4]).
Full summary, score breakdown and related studies → Original source
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2017-10-16
Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease
38/100 ✓ Peer-reviewed Disease mechanisms Brain research
Key finding: Previous studies have shown that the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) that have anti-diabetic properties show very promising effects in animal models of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-16
Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice
40/100 ✓ Peer-reviewed TREM2 and immune genetics Brain, behavior, and immunity
Key finding: Patients treated with chemotherapy often report pain and paresthesias in a "glove-and-stocking" distribution. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-16
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
52/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration
Key finding: Here we report that TREM2 deficiency leads to accelerated and exacerbated hyperphosphorylation and aggregation of tau in a humanized mouse model of tauopathy. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-16
Unravelling positive aspects of caregiving in dementia: An integrative review of research literature
70/100 ✓ Peer-reviewed Caregiving International journal of nursing studies
Key finding: The findings of this review provide insight into catalysing the paradigm shift from 'reducing stress' to 'optimising positive experience' in developing caregiving support services for dementia, and may guide future empirical study to explain this unique dimension of caregiving experience. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-10-14
Gut microbiota changes in the extreme decades of human life: a focus on centenarians
57/100 ✓ Peer-reviewed Disease mechanisms Cellular and molecular life sciences : CMLS
Key finding: We likewise address the role of GM in neurodegenerative diseases such as Parkinson's and Alzheimer's, and its possible therapeutic use, taking advantage of the fact that centenarians are characterized by an extreme (healthy) phenotype versus patients suffering from age-related pathologies.
Full summary, score breakdown and related studies → Original source
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2017-10-14
Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging
46/100 ✓ Peer-reviewed TREM2 and immune genetics Biological psychiatry
Key finding: However, the precise mechanisms by which microglia alter the course of AD neuropathology remain poorly understood. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-13
Alzheimer’s Disease Biomarkers and Future Decline in Cognitive Normal Older Adults
57/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer s Disease
Key finding: 14% participants increased their global Clinical Dementia Rating (CDR) score from 0 to 0.5 during follow-up. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-12
Readily Identifiable Risk Factors of Nursing Home Residents' Oral Hygiene: Dementia, Hospice, and Length of Stay
45/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: The findings identify resident subgroups at especially high risk of poor oral health who can be targeted in quality improvement efforts related to oral hygiene; they also indicate need to improve the accuracy of how MDS items are completed. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-10-12
End-of-life care: A qualitative study comparing the views of people with dementia and family carers
38/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: Seven areas were identified as important to end-of-life care for people with dementia and/or family carers.
Full summary, score breakdown and related studies → Original source
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2017-10-12
Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome
42/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Free radical biology & medicine
Key finding: We conclude by pointing to the need for additional studies to explore the biology of signaling endosomes in normal neurons and to elucidate their role in the pathogenesis of neurodegeneration.
Full summary, score breakdown and related studies → Original source
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2017-10-11
Building IoT Services for Aging in Place Using Standard-Based IoT Platforms and Heterogeneous IoT Products
41/100 ✓ Peer-reviewed Cognitive tests and assessment Sensors
Key finding: Accordingly, seniors' ability to live independently and comfortably in their current home for as long as possible has been crucial to reduce the societal cost for caregiving and thus give family members peace of mind, called 'aging in place' (AIP). +4 more findings
Full summary, score breakdown and related studies → Original source
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