Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,276–15,300 of 27,380 studies, newest first · page 612 of 1096.
March 2017 16
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2017-03-01
18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy
52/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: More specifically, 18F-AV-1451 binding was significantly increased in patients with Alzheimer's disease, relative to patients with progressive supranuclear palsy and with control subjects, in the hippocampus and in occipital, parietal, temporal, and frontal cortices (t's > 2.2, P's < 0.04). +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-01
Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies
41/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: Fluorescence microscopy demonstrated intense labelling of non-ghost and ghost tangles with PBB3 and AV-1451, while dystrophic neurites were more clearly detected by PBB3 in brains of Alzheimer's disease and diffuse neurofibrillary tangles with calcification, characterized by accumulation of all six tau isoforms. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-01
Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition
61/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: For amyloid positron emission tomography positive (Aβ+) subjects, flortaucipir neocortical standard uptake value ratio was significantly higher with more advanced clinical stage (Alzheimer's disease > mild cognitive impairment > older cognitively normal) and was significantly elevated for Aβ+ mild cognitive impairment and Alzheimer's disease subjects relative to the respective Aβ- subjects. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-01
Exercise training for neural recovery in a restricted sample of pediatric brain tumor survivors: a controlled clinical trial with crossover of training versus no training
45/100 ✓ Peer-reviewed Hippocampus size on brain scans Neuro-oncology
Key finding: Exercise training is an effective means for promoting white matter and hippocampal recovery and improving reaction time in children treated with cranial radiation for brain tumors. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-01
Traumatic Brain Injury and Neuropsychiatric Complications
41/100 ✓ Peer-reviewed Clinical safety Indian journal of psychological medicine
Key finding: Traumatic brain injury (TBI) occurs when a blow or jolt to the head or a penetrating injury results in damage to the brain. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-01
Extracellular matrix inflammation in vascular cognitive impairment and dementia
43/100 ✓ Peer-reviewed Inflammation and the immune system Clinical science (London, England : 1979)
Key finding: Lacunar strokes and white matter (WM) injury are consequences of SVD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-01
Alzheimer's disease as an inflammatory disease
44/100 ✓ Peer-reviewed Inflammation and the immune system Biomolecular concepts
Key finding: In this short review, we focus on neuroinflammation in AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-03-01
Physical Frailty, Cognitive Impairment, and the Risk of Neurocognitive Disorder in the Singapore Longitudinal Ageing Studies
53/100 ✓ Peer-reviewed Cognitive tests and assessment The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: The independent and combined effects of physical and cognitive domains of frailty in predicting the development of mild cognitive impairment (MCI) or dementia are not firmly established. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-03-01
Heterogeneity of neuroanatomical patterns in prodromal Alzheimer's disease: links to cognition, progression and biomarkers
65/100 ✓ Peer-reviewed Mild cognitive impairment Brain : a journal of neurology
Key finding: See Coulthard and Knight (doi:10.1093/aww335) for a scientific commentary on this article.
Full summary, score breakdown and related studies → Original source
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2017-03-01
Defining the Relationship Between Hypertension, Cognitive Decline, and Dementia: a Review
53/100 ✓ Peer-reviewed Risk factors Current hypertension reports
Key finding: Although the understanding of the relationship between cardiocirculatory dysfunction and brain health has improved significantly over the last several decades, it is still unclear whether hypertension constitutes a potentially treatable risk factor for cognitive decline and dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-01
Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies
70/100 ✓ Peer-reviewed Caregiving JAMA psychiatry
Key finding: There were 987 participants (290 from Vantaa 85+, 241 from the Cambridge City Over-75s Cohort, and 456 from the Cognitive Function and Ageing Study) with neuropathologic data; mean (SD) age at death was 90 (6.4) years, including 682 women (69%). +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-01
Neuropsychiatric Symptoms in Alzheimer Disease, Vascular Dementia, and Mixed Dementia
48/100 ✓ Peer-reviewed Brain scans and imaging Neuro-degenerative diseases
Key finding: Neuropsychiatric symptoms (NPS) are common in Alzheimer disease (AD) and vascular dementia (VaD), and are distressful to patients and caregivers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-03-01
Limitations of Sacubitril/Valsartan in the Management of Heart Failure
46/100 ✓ Peer-reviewed Treatments American journal of therapeutics
Key finding: The PARADIGM-HF (Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure) trial was a double-blind trial that randomized 8442 patients with heart failure (HF) with reduced ejection fraction (HFrEF) to receive twice daily dosing of either 200 mg of LCZ696 or 10 mg of enalapril in addition to standard medical therapy for HF.
Full summary, score breakdown and related studies → Original source
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2017-03-01
Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE ε4 Genotype
62/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: Cognitively normal elderly individuals who engage in specific mentally stimulating activities even in late life have a decreased risk of incident MCI. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-03-01
Regional Overlap of Pathologies in Lewy Body Disorders
44/100 ✓ Peer-reviewed Genetics Journal of neuropathology and experimental neurology
Key finding: These results highlight the common concurrence of pathologies in patients with LBD that may have an impact on the clinical expression of the diseases.
Full summary, score breakdown and related studies → Original source
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2017-03-01
Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers: A Review
51/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: High-dose DHA supplementation in APOE4 carriers before the onset of AD dementia can be a promising approach to decrease the incidence of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
February 2017 9
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2017-02-28
Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Patients Testing Memory and Cognition
40/100 ✓ Peer-reviewed Treatments Journal of neurology and neuroscience
Key finding: Mice were treated with NIR 20 times over a four-week period and NIR treatment (600-1000 nm) was associated with a reduction in the size and number of amyloid-β plaques in the neocortex and hippocampus. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-28
Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers
71/100 ✓ Peer-reviewed Genetics Acta neuropathologica
Key finding: More than 20 genetic loci have been associated with risk for Alzheimer's disease (AD), but reported genome-wide significant loci do not account for all the estimated heritability and provide little information about underlying biological mechanisms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-28
Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β
62/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Sensitive detection of cognitive decline over the course of preclinical Alzheimer's disease is critical as the field moves toward secondary prevention trials. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-28
Lifestyle for Brain Health (LIBRA): a new model for dementia prevention
69/100 ✓ Peer-reviewed Prevention and risk International journal of geriatric psychiatry
Key finding: Lifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-02-27
Sleep and hippocampal neurogenesis: Implications for Alzheimer's disease
39/100 ✓ Peer-reviewed Risk factors Frontiers in neuroendocrinology
Key finding: The pathways connecting these symptoms are of particular interest because it is well established that sleep and circadian disruption can impair hippocampus-dependent learning and memory. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-27
Framing outcomes of post-diagnostic psychosocial interventions in dementia: the Adaptation-Coping Model and adjusting to change
31/100 ✓ Peer-reviewed Health systems and care delivery Working with Older People
Key finding: The translated Adaptation-Coping (adjusting to change) Model provides a way for service users (people with dementia and families) to conceptualise their journey with dementia post-diagnosis, and potentially provides service providers and researchers with aims for treatment and support. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-27
The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability
43/100 ✓ Peer-reviewed Inflammation and the immune system Autophagy
Key finding: Manganese (Mn), a neurotoxic metal, has the potential to induce microglia-mediated neuroinflammation as well as autophagy dysfunction. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-02-24
Neuroinflammation in glaucoma: A new opportunity
38/100 ✓ Peer-reviewed Brain scans and imaging Experimental eye research
Key finding: We then review the inflammatory pathways that have been associated with glaucoma.
Full summary, score breakdown and related studies → Original source
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2017-02-23
Activating Developmental Reserve Capacity Via Cognitive Training or Non-invasive Brain Stimulation: Potentials for Promoting Fronto-Parietal and Hippocampal-Striatal Network Functions in Old Age
41/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience
Key finding: Intervention methods such as cognitive training and non-invasive brain stimulation, e.g., transcranial direct current stimulation (tDCS), have been considered as means to buffer cognitive functions or delay cognitive decline in old age. +4 more findings
Full summary, score breakdown and related studies → Original source
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