Newest studies

Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases

50/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in cellular neuroscience

Key finding: Microglia-derived neuroinflammation has both beneficial and detrimental effects on neurons. +3 more findings

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Elimination of amyloid precursor protein in senile plaques in the brain of a patient with Alzheimer-type dementia and Down syndrome

33/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain & development

Key finding: Her karyotype [46XX, inv(9)(p12q13), i(21)(q10)] included triplication of the gene for amyloid precursor protein and the Down syndrome critical region. +4 more findings

• Down Syndrome
• Brain Biology

Full summary, score breakdown and related studies → Original source

The Impact of Gender on Atrial Fibrillation Incidence and Progression to Dementia

59/100 ✓ Peer-reviewed Risk factors The American journal of cardiology

Key finding: However, women trended toward a higher incidence of 5-year and long-term dementia and stroke compared with men. +1 more finding

• Risk Factors

Full summary, score breakdown and related studies → Original source

White matter lesions: Spatial heterogeneity, links to risk factors, cognition, genetics, and atrophy

64/100 ✓ Peer-reviewed Genetics Neurology

Key finding: These results support the hypothesis that the appearance of WMH follows age and disease-dependent regional distribution patterns, potentially influenced by differential underlying pathophysiologic mechanisms, and possibly with a differential link to vascular and neurodegenerative changes. +4 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment

46/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy- participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. +1 more finding

• Early Stage

Full summary, score breakdown and related studies → Original source

Advance Care Planning in a Geriatric Primary Care Clinic: A Retrospective Chart Review

50/100 ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

Key finding: The authors plan to reevaluate ACP statistics in the same office following a future intervention. +1 more finding

• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Management of behavioral and psychological symptoms in people with Alzheimer's disease: an international Delphi consensus

50/100 ✓ Peer-reviewed Caregiving International psychogeriatrics

Key finding: Our purpose was to prioritize existing and emerging treatments for BPSD in Alzheimer's disease (AD) overall, as well as specifically for agitation and psychosis. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Traffic-Related Air Pollution, APOE ε4 Status, and Neurodevelopmental Outcomes among School Children Enrolled in the BREATHE Project (Catalonia, Spain)

41/100 ✓ Peer-reviewed Risk factors Environmental Health Perspectives

Key finding: APOE ε4 allele carriers had significantly higher behavior problem scores than noncarriers, and adverse associations with PAHs and NO2 were stronger or limited to ε4 carriers for behavior problem scores (P-interaction 0.03 and 0.04), caudate volume (P-interaction 0.04 and 0.03), and inattentiveness trajectories (P-interaction 0.15 and 0.08, respectively). +3 more findings

• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Research on caregiver stress: time for integration and application

39/100 ✓ Peer-reviewed Caregiving International psychogeriatrics

Key finding: The six papers published here represent a snapshot of prevailing lines of inquiry and enhance our knowledge regarding: predictors of psychological distress for dementia family caregivers in Japan (Shikimoto et al., 2017) and for Indonesian and Burmese foreign domestic workers caring for frail older adults in Singapore (Ha et al., 2018); identification of a threshold number of behavioral symptoms in those with dementia associated with caregiver distress (Arthur et al., 2017); the influence of specific illness factors on caregiver stress, including comorbid diabetes in patients with Alzheimer's disease (Li et al., 2018) and a comparison of the effects of behavioral disturbances on caregiver burden across three types of dementia (Liu et al., 2017); and the application of data on caregiver stress to inform the development of a multi-component framework for preventing depression in caregivers of those with dementia (Ying et al., 2017).

• Caregiving

Full summary, score breakdown and related studies → Original source

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

45/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain : a journal of neurology

Key finding: This indicates that triplication of chromosome 21 genes other than APP is likely to have an important role to play in Alzheimer's disease pathogenesis in individuals who have Down syndrome.

• Brain Biology
• Digital Tools

Full summary, score breakdown and related studies → Original source

Amyloid toxicity in Alzheimer's disease

38/100 ✓ Peer-reviewed End-of-life care Reviews in the neurosciences

Key finding: Aβ formation results from the amyloidogenic cleavage of human amyloid precursor protein (APP).

• Brain Biology

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Spatial navigation deficits - overlooked cognitive marker for preclinical Alzheimer disease?

38/100 ✓ Peer-reviewed Risk factors Nature reviews. Neurology

Key finding: By contrast, cognitive fingerprints for incipient AD are virtually non-existent as diagnostics and outcomes measures are still focused on episodic memory deficits as the gold standard for AD, despite their low sensitivity and specificity for identifying at-risk individuals. +4 more findings

• Early Stage
• Treatments

Full summary, score breakdown and related studies → Original source

Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia

72/100 ✓ Peer-reviewed Prevention trials JAMA

Key finding: In this cohort of older adults, increased numbers of optimal cardiovascular health metrics and a higher cardiovascular health score were associated with a lower risk of dementia and lower rates of cognitive decline. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Sex differences in Alzheimer disease - the gateway to precision medicine

38/100 ✓ Peer-reviewed Brain scans and imaging Nature reviews. Neurology

Key finding: The cumulative evidence reviewed indicates sex-specific patterns of disease manifestation as well as sex differences in the rates of cognitive decline and brain atrophy, suggesting that sex is a crucial variable in disease heterogeneity.

Full summary, score breakdown and related studies → Original source

Advance Care Planning in Cognitively Impaired Older Adults

38/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: The importance of providing anticipatory guidance and eliciting values to guide future care to create a shared framework between clinicians, individuals, and surrogate decision-makers is emphasized. +4 more findings

• End-of-Life Care

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Postoperative Cognitive Dysfunction and Noncardiac Surgery

38/100 ✓ Peer-reviewed Clinical safety Anesthesia and analgesia

Key finding: Postoperative cognitive dysfunction (POCD) is an objectively measured decline in cognition postoperatively compared with preoperative function. +3 more findings

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Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

38/100 ✓ Peer-reviewed Disease mechanisms Human molecular genetics

Key finding: BFT administration significantly ameliorated mitochondrial dysfunction and attenuated oxidative damage and inflammation. +3 more findings

• Brain Biology
• Treatments

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The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses

52/100 ✓ Peer-reviewed Long-term cohort studies Journal of neuropathology and experimental neurology

Key finding: Alzheimer's Disease Centers (ADCs) have worked for >30 years studying human brains, with the goals of achieving new research breakthroughs. +3 more findings

• Brain Biology

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Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

49/100 ✓ Peer-reviewed TREM2 and immune genetics Cell reports

Key finding: Homozygous missense mutations in TREM2 cause Nasu-Hakola disease (NHD), an early-onset dementia. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Mild Cognitive Impairment in Clinical Practice: A Review Article

47/100 ✓ Peer-reviewed Mild cognitive impairment American journal of Alzheimer's disease and other dementias

Key finding: The spectrum of cognitive decline in the elderly ranges from what can be classified as normal cognitive decline with aging to subjective cognitive impairment to mild cognitive impairment (MCI) to dementia. +3 more findings

• Early Stage

Full summary, score breakdown and related studies → Original source

Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies

75/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: In this study, we found that ePVS counts were not associated with cognitive dysfunction in the general population. +4 more findings

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Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting

60/100 ✓ Peer-reviewed Prevention and risk JAMA neurology

Key finding: Of 3894 participants, 1671 underwent PET imaging and were included in the study; 2198 did not undergo imaging, and 25 were excluded for other reasons. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

71/100 ✓ Peer-reviewed Genetics JAMA neurology

Key finding: After correcting for multiple comparisons using the Bonferroni procedure, we observed a statistically significant interaction between APOE-ε4 and sex on CSF total tau (β = 0.41; 95% CI, 0.27-0.55; P Conclusions and relevance We provide robust evidence of a stronger association between APOE-ε4 and CSF tau levels among women compared with men across multiple independent data sets. +4 more findings

• Genetics
• Biomarkers
• Brain Biology

Full summary, score breakdown and related studies → Original source

Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1-42

35/100 ✓ Peer-reviewed Biomarkers Oxidative medicine and cellular longevity

Key finding: An important worldwide health problem as the result of current lifestyle is metabolic syndrome (MS). +3 more findings

• Brain Biology

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Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease

68/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: These results suggest that increasing levels of tau most consistently relate to declines in cognition preceding biomarker collection. +3 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source