Newest studies

MRI Asymmetry Index of Hippocampal Subfields Increases Through the Continuum From the Mild Cognitive Impairment to the Alzheimer's Disease

46/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in neuroscience

Key finding: We found a general trend of increased degree of asymmetry with increasing severity of diagnosis. +4 more findings

• Early Stage

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Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice

39/100 ✓ Peer-reviewed Inflammation and the immune system Proceedings of the National Academy of Sciences of the United States of America

Key finding: AD patients commonly have unprovoked seizures compared with age-matched controls.

• Brain Biology

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Developing consensus among movement disorder specialists on clinical indicators for identification and management of advanced Parkinson's disease: a multi-country Delphi-panel approach

38/100 ✓ Peer-reviewed Clinical safety Current medical research and opinion

Key finding: Identifying patients progressing to APD and suitable for device-aided therapies will enable general neurologists to assess the need for referral to movement disorder specialists and improve the quality of care and patient outcomes. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

SPECT and PET imaging in Alzheimer's disease

43/100 ✓ Peer-reviewed Mild cognitive impairment Annals of nuclear medicine

Key finding: As a result, SPECT and PET have proposed to serve as biomarkers in recently revised diagnostic clinical criteria for the early diagnosis of AD and the prediction of progression to AD in mild cognitive impairment (MCI) subjects.

• Brain Scans
• Early Stage
• Brain Biology

Full summary, score breakdown and related studies → Original source

Biomarkers for Alzheimer's disease: current status and prospects for the future

38/100 ✓ Peer-reviewed Biomarkers Journal of internal medicine

Key finding: Standardization efforts have given certified reference materials for CSF Aβ42, with the aim to harmonize results between assay formats that would allow for uniform global reference limits and cut-off values. +2 more findings

• Biomarkers
• Diagnosis

Full summary, score breakdown and related studies → Original source

Implementing the centiloid transformation for 11C-PiB and β-amyloid 18F-PET tracers using CapAIBL

43/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: Using the calibration images, there was a very strong agreement, and very little bias between the centiloid values computed using CapAIBL and those computed using the standard method with R2 > 0.97 across all tracers. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Oral Presentations of the 2018 Annual Meeting of the Congress of Neurological Surgeons

37/100 ✓ Peer-reviewed Health systems and care delivery Neurosurgery

Key finding: Our robust machine learning based analytical pipeline consists of segmentation, radiomic texture extraction, feature normalization and selection, and predictive-model generation. +4 more findings

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Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

54/100 ✓ Peer-reviewed How common it is Nature reviews. Drug discovery

Key finding: Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis represent a major socio-economic challenge in view of their high prevalence yet poor treatment. +4 more findings

• Other Dementias

Full summary, score breakdown and related studies → Original source

Planning for an uncertain future in progressive neurological disease: a qualitative study of patient and family decision-making with a focus on eating and drinking

64/100 ✓ Peer-reviewed End-of-life care BMC neurology

Key finding: Issues with eating and drinking are often overlooked.

• Caregiving

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The importance of trust-based relations and a holistic approach in advance care planning with people with dementia in primary care: a qualitative study

41/100 ✓ Peer-reviewed End-of-life care BMC geriatrics

Key finding: ACP is facilitated by an open relationship based on trust between the GP, the person with dementia and his/her family caregiver, in which both medical and non-medical issues are addressed.

• End-of-Life Care
• Care Services

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Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer's disease

50/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's research & therapy

Key finding: There is accumulating evidence that synaptic loss precedes neuronal loss and correlates best with impaired memory formation in Alzheimer's disease (AD). +3 more findings

• Biomarkers
• Brain Biology

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Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

57/100 ✓ Peer-reviewed TREM2 and immune genetics Alzheimer's research & therapy

Key finding: Reliable biomarkers of frontotemporal dementia (FTD) are currently lacking. +3 more findings

• Genetics
• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

Does Severity of Alzheimer's Disease Contribute to Its Responsiveness to Modifying Gut Microbiota? A Double Blind Clinical Trial

47/100 ✓ Peer-reviewed Disease mechanisms Frontiers in neurology

Key finding: Alzheimer's disease (AD) is associated with cognitive dysfunction. +4 more findings

• Clinical Trials

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Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases

38/100 ✓ Peer-reviewed Disease mechanisms Neurochemistry international

Key finding: It is widely accepted that highly diverse and stable microbiota promote overall human health. +3 more findings

• Brain Biology
• Risk Factors

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Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer's disease

41/100 ✓ Peer-reviewed Biomarkers Translational psychiatry

Key finding: Riluzole significantly enhanced cognition and reduced Aβ42, Aβ40, Aβ oligomers levels, and Aβ plaque load in 5XFAD mice. +1 more finding

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

Dietary Patterns and Cognitive Function among Older Community-Dwelling Adults

52/100 ✓ Peer-reviewed Prevention trials Nutrients

Key finding: Estimates for the highest vs. lowest tertile in models adjusting for age, sex, education, energy intake, lifestyle variables and retest effect showed greater adherence to the Mediterranean score was associated with better baseline global cognitive function (β (95% CI) = 0.33 (0.11, 0.55)). +4 more findings

• Lifestyle

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TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

41/100 ✓ Peer-reviewed Disease mechanisms The Journal of experimental medicine

Key finding: Our study suggests that astrocytic TFEB plays a functional role in modulating extracellular tau and the propagation of neuronal tau pathology in tauopathies such as Alzheimer's disease.

• Brain Biology

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Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults

58/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: We tested the hypothesis that BBB breakdown is associated with cognitive decline and inflammation in nondemented elders. +3 more findings

• Brain Biology

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Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors

53/100 ✓ Peer-reviewed Long-term cohort studies Frontiers in neurology

Key finding: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. +3 more findings

• Treatments
• Brain Scans

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Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank

53/100 ✓ Peer-reviewed Long-term cohort studies Scientific reports

Key finding: We estimated the association between baseline neighbourhood-level exposure to airborne pollutants (particulate matter and nitrogen oxides) and (1) cognitive test performance at baseline and (2) cognitive score change between baseline and 2.8-year follow-up, in 86,759 middle- to older-aged adults from the UK Biobank general population cohort. +3 more findings

• Risk Factors

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Potentially Inappropriate Prescribing in Australian Nursing Home Residents with Advanced Dementia: A Substudy of the IDEAL Study

55/100 ✓ Peer-reviewed Treatments Journal of palliative medicine

Key finding: Use of potentially inappropriate medications in Australian nursing home residents with advanced dementia is common. +2 more findings

• Clinical Trials
• Treatments
• Care Services

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Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation

45/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: Sixteen single variants and 19 genes that met criteria for significant or suggestive associations after multiple-testing correction were evaluated for replication in four independent samples; three with whole exome sequencing (2,778 cases, 7,262 controls) and one with genome-wide genotyping imputed to the Haplotype Reference Consortium panel (9,343 cases, 11,527 controls). +1 more finding

• Genetics
• Policy

Full summary, score breakdown and related studies → Original source

Kynurenine pathway changes in late-life depression with memory deficit

46/100 ✓ Peer-reviewed Risk factors Psychiatry research

Key finding: Kynurenine pathway (KP) activation is associated with many neuropsychiatric diseases, such as major depressive disorder (MDD) and Alzheimer's disease (AD). +4 more findings

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Biomarkers of dementia in obstructive sleep apnea

55/100 ✓ Peer-reviewed Risk factors Sleep medicine reviews

Key finding: Hence, the identification of patients at risk of cognitive decline due to obstructive sleep apnea may significantly improve preventive strategies and treatment decision-making. +1 more finding

• Risk Factors
• Biomarkers
• Brain Biology

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IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer's disease: Systematic Review and Meta-Analysis

72/100 ✓ Peer-reviewed Risk factors Scientific reports

Key finding: We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are significantly higher in elderly with depression and Alzheimer's disease. +3 more findings

Full summary, score breakdown and related studies → Original source