Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 7,476–7,500 of 27,380 studies, newest first · page 300 of 1096.
July 2023 25
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2023-07-26
Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF
50/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Science advances
Key finding: Notably, lowering APP-βCTF Tyr 682 phosphorylation below normal constitutive levels boosts v-ATPase assembly and activity, suggesting that v-ATPase may also be modulated tonically by phospho-APP-βCTF. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-07-26
Artificial intelligence for dementia-Applied models and digital health
56/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Such approaches will benefit also from improvements in remote data measurement, whether cognitive (e.g., online), or naturalistic (e.g., watch-based accelerometry). +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-07-25
Vertical Graphene-Based Printed Electrochemical Biosensor for Simultaneous Detection of Four Alzheimer’s Disease Blood Biomarkers
43/100 ✓ Peer-reviewed Cognitive tests and assessment Biosensors
Key finding: The customized electrochemical micro-workstation incorporates four electro-chemical control chips, enabling the sensor to simultaneously analyze four biomarkers. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-25
Trem2 Enhances Demyelination in the Csf1r+/- Mouse Model of Leukoencephalopathy
41/100 ✓ Peer-reviewed TREM2 and immune genetics Biomedicines
Key finding: These data suggest that TREM2 contributes to microglial dyshomeostasis in CRL.
Full summary, score breakdown and related studies → Original source
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2023-07-25
Profiling of plasma biomarkers in the context of memory assessment in a tertiary memory clinic
52/100 ✓ Peer-reviewed Biomarkers Translational psychiatry
Key finding: While in the whole MCI group, only GFAP was associated with Aβ PET centiloid. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-07-25
Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study
61/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Biomarkers were correlated with one another. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-25
Plasma biomarkers of neurodegeneration in mild cognitive impairment with Lewy bodies
52/100 ✓ Peer-reviewed Biomarkers Psychological medicine
Key finding: Probable MCI-LB had elevated GFAP (p < 0.001) and NfL (p = 0.012) relative to controls, but not significantly lower Aβ42/40 (p = 0.06). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-25
Anti-Amyloid Immunotherapies for Alzheimer's Disease: A 2023 Clinical Update
43/100 ✓ Peer-reviewed Treatments Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Key finding: The clinical effects of these agents are modest, however, and associated with amyloid-related imaging abnormalities (ARIA).
Full summary, score breakdown and related studies → Original source
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2023-07-24
Caregiver burden related to feeding process in Alzheimer's disease
55/100 ✓ Peer-reviewed Caregiving Dementia & neuropsychologia
Key finding: We included 60 AD individuals-caregivers dyads. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-24
The fructose survival hypothesis for obesity
41/100 ✓ Peer-reviewed Risk factors Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Key finding: While this response is aimed to be modest and short-lived, the response in humans is exaggerated due to gain of 'thrifty genes' coupled with a western diet rich in foods that contain or generate fructose. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-24
Current Diagnostic Pathways for Alzheimer's Disease: A Cross-Sectional Real-World Study Across Six Countries
46/100 ✓ Peer-reviewed Health systems and care delivery Journal of Alzheimer's disease reports
Key finding: Factors that influenced risk of not receiving a diagnosis were HCP type (higher for primary care physicians versus specialists) and region (highest in China and Germany).
Full summary, score breakdown and related studies → Original source
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2023-07-24
Personalized Integrated Care Promoting Quality of Life for Older People: Protocol for a Multicenter Randomized Controlled Trial
44/100 ✓ Peer-reviewed Treatments JMIR research protocols
Key finding: The study protocol is part of a project approved and funded by the European Commission Horizon 2020 (grant agreement number 875221). +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-24
Psychosocial and Behavioral Outcomes for Persons With Cognitive Impairment and Caregivers Following Amyloid-β PET Scan Disclosure: A Systematic Review
54/100 ✓ Peer-reviewed Biomarkers Alzheimer disease and associated disorders
Key finding: Ten papers were identified from 7 studies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-22
Associations of Alzheimer's-related plasma biomarkers with cognitive decline in Parkinson's disease
41/100 ✓ Peer-reviewed Biomarkers Journal of neurology
Key finding: Plasma glial fibrillary acidic protein significantly correlated with cognitive function tests, including all subdomains, with a notable increase in the PDD group compared with the HC and PDND groups, while plasma neurofilament light chain captured both cognitive decline and disease severity in the PDND and PDD groups. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-22
Expected and diagnosed rates of mild cognitive impairment and dementia in the U.S. Medicare population: observational analysis
51/100 ✓ Peer-reviewed Disparities Alzheimer's research & therapy
Key finding: These results highlight the need to increase the overall detection rates of MCI and of dementia particularly in socioeconomically disadvantaged groups. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-22
Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer's Disease? A Randomized Controlled Trial
58/100 ✓ Peer-reviewed Treatments Brain sciences
Key finding: A significant intervention effect was observed for all outcome measures (global cognitive function and instrumental activities of daily living). +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-21
A universal neocortical mask for Centiloid quantification
57/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: In the GAAIN dataset, the universal mask led to a small reduction in the variance of the YC, and a small increase in the inter-tracer agreement. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-21
Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders
54/100 ✓ Peer-reviewed Biomarkers The Australian and New Zealand journal of psychiatry
Key finding: Large differences were seen between bvFTD (mean NfL 34.9 pg/mL) and all PPDs and controls (all < 11 pg/mL). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-21
The effects of COVID-19 on cognitive performance in a community-based cohort: a COVID symptom study biobank prospective cohort study
69/100 ✓ Peer-reviewed Cognitive tests and assessment EClinicalMedicine
Key finding: Stratification by self-reported recovery revealed that deficits were only detectable in SARS-CoV-2 positive individuals who did not feel recovered from COVID-19, whereas individuals who reported full recovery showed no deficits. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-07-21
Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants
66/100 ✓ Peer-reviewed Long-term cohort studies BMC medicine
Key finding: Increasing evidence suggests an association between pro-inflammatory diets and cognitive function. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-21
Frontotemporal Dementia, Where Do We Stand? A Narrative Review
52/100 ✓ Peer-reviewed Digital health tools International journal of molecular sciences
Key finding: Here, we aim to provide a state of the art on the pathogenesis of this disease, starting with established findings and integrating them with more recent ones. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-19
Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life
41/100 ✓ Peer-reviewed Disease mechanisms Science translational medicine
Key finding: We found 32 dementia-associated plasma proteins that were involved in proteostasis, immunity, synaptic function, and extracellular matrix organization. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-18
Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial
84/100 ✓ Peer-reviewed Prevention and risk Lancet (London, England)
Key finding: These findings suggest that a hearing intervention might reduce cognitive change over 3 years in populations of older adults at increased risk for cognitive decline but not in populations at decreased risk for cognitive decline. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-18
Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons
87/100 ✓ Peer-reviewed Prevention and risk New England Journal of Medicine
Key finding: Among cognitively unimpaired participants with a family history of dementia, changes in cognition and brain MRI outcomes from baseline to year 3 did not differ significantly between those who followed the MIND diet and those who followed the control diet with mild caloric restriction. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-17
Trial of Solanezumab in Preclinical Alzheimer's Disease
79/100 ✓ Peer-reviewed Brain scans and imaging The New England journal of medicine
Key finding: Solanezumab, which targets monomeric amyloid in persons with elevated brain amyloid levels, did not slow cognitive decline as compared with placebo over a period of 240 weeks in persons with preclinical Alzheimer's disease. +2 more findings
Full summary, score breakdown and related studies → Original source
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