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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 14,976–15,000 of 27,380 studies, newest first · page 600 of 1096.

June 2017 25

  1. 2017-06-21

    A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

    ✓ Peer-reviewed Risk factors Alzheimer's & dementia (New York, N. Y.)

    Key finding: ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.

    Full summary, score breakdown and related studies → Original source

  2. 2017-06-21

    TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

    ✓ Peer-reviewed TREM2 and immune genetics Frontiers in aging neuroscience

    Key finding: By pairing with different triggering receptors expressed on myeloid cell (TREM) proteins, DAP12 can mediate both positive and negative cellular responses. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2017-06-21

    Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment

    ✓ Peer-reviewed Mild cognitive impairment The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Stimulation significantly increased overall SO and spindle power, amplified spindle power during SO up-phases, and led to stronger synchronization between SO and spindle power fluctuations in EEG recordings. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2017-06-20

    A neuroimaging approach to capture cognitive reserve: Application to Alzheimer's disease

    ✓ Peer-reviewed Risk factors Human brain mapping

    Key finding: To validate this method, we showed that education correlated with mean W-scores in whole-brain (r = -0.090, P < 0.05) and temporoparietal (r = -0.122, P < 0.01) masks, indicating that higher education was associated with more CR (i.e. greater atrophy than predicted from cognitive performance). +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2017-06-20

    Intestinal microbial dysbiosis aggravates the progression of Alzheimer's disease in Drosophila

    ✓ Peer-reviewed Disease mechanisms Nature communications

    Key finding: This work highlights the importance of gut-brain crosstalk as a fundamental regulatory system in modulating Alzheimer's disease neurodegeneration.

    Full summary, score breakdown and related studies → Original source

  6. 2017-06-20

    16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer's Post-Mortem Brain

    ✓ Peer-reviewed Inflammation and the immune system Frontiers in aging neuroscience

    Key finding: This is now seen to be a significant contributor to pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2017-06-20

    Body mass index in midlife and dementia: Systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies

    ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: We conducted a meta-analysis of the conflicting epidemiologic evidence on the association between midlife body mass index (BMI) and dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2017-06-20

    Concordance between brain 18F-FDG PET and cerebrospinal fluid biomarkers in diagnosing Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Revista espanola de medicina nuclear e imagen molecular

    Key finding: Cortical posterior hypometabolism on PET imaging with 18 F-FDG (FDG-PET), and altered levels of Aß 1-42 peptide, total Tau (tTau) and phosphorylated Tau (pTau) proteins in cerebrospinal fluid (CSF) are established diagnostic biomarkers in Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2017-06-19

    Caregiver burden is increased in Parkinson's disease with mild cognitive impairment (PD-MCI)

    ✓ Peer-reviewed Caregiving Translational neurodegeneration

    Key finding: Mean Zarit Burden Interview (ZBI) score increased significantly between carers of PD-N (M = 13.39, SD = 12.22) compared to those of PD-MCI patients (M = 22.00, SD = 10.8), and between carers of PD-MCI and PDD patients (M = 29.33, SD = 9.59). +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2017-06-19

    Aberrant Intrinsic Activity and Connectivity in Cognitively Normal Parkinson's Disease

    ✓ Peer-reviewed Brain scans and imaging Frontiers in aging neuroscience

    Key finding: The results revealed abnormally increased and decreased ALFF and ReHo in PD-CN patients within the default mode network (posterior cingulate, inferior parietal cortex, parahippocampus, entorhinal cortex), sensorimotor cortex (primary motor, pre/post-central gyrus), basal ganglia (putamen, caudate), and posterior cerebellar lobule VII, which mediates cognition. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2017-06-18

    Diagnosis of Alzheimer's Disease Based on Structural MRI Images Using a Regularized Extreme Learning Machine and PCA Features

    ✓ Peer-reviewed Long-term cohort studies Journal of healthcare engineering

    Key finding: Despite its significance, there is currently no cure for it. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2017-06-17

    One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

    ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

    Key finding: Hyperhomocysteinemia is a risk factor for cognitive decline and dementia, including Alzheimer disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2017-06-16

    Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory

    ✓ Peer-reviewed Disease mechanisms The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Moreover, electrophysiological and behavioral studies performed on animals of both sexes showed that blocking Aβ function, by using anti-murine Aβ antibodies or APP knock-out mice, prevents the cGMP-dependent enhancement of LTP and memory. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2017-06-16

    End of life care for people with dementia: The views of health professionals, social care service managers and frontline staff on key requirements for good practice

    ✓ Peer-reviewed End-of-life care PloS one

    Key finding: The significant challenges of providing good end of life care for people with dementia requires that different forms of expertise should be recognised and used; including the skills and knowledge of care assistants. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2017-06-16

    Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts

    ✓ Peer-reviewed Cognitive tests and assessment The Lancet. Neurology

    Key finding: Cognitive decline is a debilitating manifestation of disease progression in Parkinson's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2017-06-15

    Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia

    ✓ Peer-reviewed Cognitive tests and assessment The Cochrane database of systematic reviews

    Key finding: Prevention of cognitive impairment and dementia is an important public health goal. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2017-06-13

    Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches

    ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology

    Key finding: Progressive supranuclear palsy (PSP), previously believed to be a common cause of atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes that are associated with a characteristic 4-repeat tau neuropathology. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2017-06-13

    Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population

    ✓ Peer-reviewed Long-term cohort studies American Journal of Epidemiology

    The UK Biobank cohort is a population-based cohort of 500,000 participants recruited in the United Kingdom (UK) between 2006 and 2010.

    Full summary, score breakdown and related studies → Original source

  19. 2017-06-13

    Practical risk score for 5-, 10-, and 20-year prediction of dementia in elderly persons: Framingham Heart Study

    ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: With a rapidly aging population, general practitioners are confronting the challenge of how to determine those who are at greatest risk for dementia and potentially need more specialized follow-up to mitigate symptoms early in its course. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2017-06-13

    Evaluation of Small-Animal PET Outcome Measures to Detect Disease Modification Induced by BACE Inhibition in a Transgenic Mouse Model of Alzheimer Disease

    ✓ Peer-reviewed Drug development Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: In this study, we investigated the effects of chronic administration of an inhibitor of the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) on Alzheimer-related pathology by multitracer PET imaging in transgenic APPPS1-21 (TG) mice. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2017-06-13

    Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology

    ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica

    Key finding: Mutations and/or differential expression of microglial specific receptors such as TREM2, CD33, and CR3 have been associated with strong increased risk for developing Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2017-06-13

    Validity and power of minimization algorithm in longitudinal analysis of clinical trials

    ✓ Peer-reviewed Treatments Biostatistics & epidemiology

    Key finding: Our analyses demonstrated minimization had conservative type I errors when the prognostic factor used in the minimization algorithm had a relatively strong correlation with the outcome and was not adjusted for in analyses.

    Full summary, score breakdown and related studies → Original source

  23. 2017-06-12

    Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging

    ✓ Peer-reviewed Prevention and risk Neural plasticity

    Key finding: Juxtaposed against this burgeoning segment of the population is evidence that nonpathological aging is associated with an increased risk for cognitive decline in a variety of domains, changes that can cause mild disability even before the onset of dementia. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2017-06-11

    Assistive technology for memory support in dementia

    ✓ Peer-reviewed Digital health tools The Cochrane database of systematic reviews

    Key finding: Main results We identified no studies which met the inclusion criteria.

    Full summary, score breakdown and related studies → Original source

  25. 2017-06-09

    YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies

    ✓ Peer-reviewed Biomarkers Journal of Neuroinflammation

    Key finding: We found that brain YKL-40 immunoreactivity was observed in a subset of astrocytes in all four diseases and in controls. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →