Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,476–12,500 of 27,380 studies, newest first · page 500 of 1096.
September 2019 25
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2019-09-14
Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment
50/100 ✓ Peer-reviewed Mild cognitive impairment Human brain mapping
Key finding: PET is a very promising methodology for differential diagnosis and novel targets of PET imaging might also serve as biomarkers for disease-modifying therapeutic interventions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-13
The endotoxin hypothesis of neurodegeneration
41/100 ✓ Peer-reviewed Disease mechanisms Journal of neuroinflammation
Key finding: Peripheral diseases that elevate blood endotoxin, such as sepsis, AIDS and liver failure, also result in neurodegeneration.
Full summary, score breakdown and related studies → Original source
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2019-09-13
Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study
60/100 ✓ Peer-reviewed Mild cognitive impairment The Lancet. Neurology
Key finding: The models could aid clinicians in the interpretation of CSF biomarker and hippocampal volume results in individuals with MCI, and help research and clinical settings to prepare for a future of precision medicine in Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2019-09-13
Microglia in Brain Development, Homeostasis, and Neurodegeneration
46/100 ✓ Peer-reviewed Genetics Annual review of genetics
Key finding: Advances in human genetics have implicated a growing number of genes in neurodegenerative diseases, providing insight into pathological processes. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-12
Neurofilament light chain plasma concentration predicts neurodegeneration and clinical progression in nondemented elderly adults
55/100 ✓ Peer-reviewed Biomarkers Aging
Key finding: Previous studies demonstrated that plasma neurofilament light chain (NFL) played important predictive roles in disease progression and neurodegeneration in the preclinical phase of familial Alzheimer's disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-12
Neuroinflammation as a Common Feature of Neurodegenerative Disorders
41/100 ✓ Peer-reviewed Brain tissue and pathology Frontiers in pharmacology
Key finding: This is a characteristic of tau protein in Alzheimer's disease and several tauopathies associated with tau unfolding, α-synuclein in Parkinson's disease, and huntingtin in Huntington disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-09-12
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
51/100 ✓ Peer-reviewed Inflammation and the immune system Stem cell reports
Key finding: We present a physiologically relevant high-yield protocol for producing iMGLs from induced pluripotent stem cells. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-11
Perceptions of precision medicine among diverse dementia caregivers and professional providers
43/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia (New York, N. Y.)
Key finding: Participants indicated skepticism regarding the use of precision medicine in their communities. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-11
Gender Differences in the Association Between Hearing Loss and Cognitive Function
48/100 ✓ Peer-reviewed Risk factors American journal of Alzheimer's disease and other dementias
Key finding: Moderate/severe hearing loss was significantly associated with lower composite z score in males (β = -28.67, 95% confidence interval [95% CI] = -57.13 to -0.20) but not in females (β = -8.82, 95% CI = -36.61 to 18.96). +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-11
Validation of Optical Coherence Tomography Retinal Segmentation in Neurodegenerative Disease
46/100 ✓ Peer-reviewed Brain scans and imaging Translational vision science & technology
Key finding: The outer plexiform layer line had one of the lowest mean error ratios (2%), while RNFL had the highest (23%). +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-11
Extra-virgin olive oil for potential prevention of Alzheimer disease
66/100 ✓ Peer-reviewed Prevention trials Revue neurologique
Key finding: Between 1935 and 1965, the Italian-American inhabitants of Roseto (Pennsylvania, USA) observed a traditional Italian diet and maintained half the mortality rates from myocardial infarction compared with neighboring cities. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-11
Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease
47/100 ✓ Peer-reviewed Risk factors Revue neurologique
Key finding: Polyphenols from fruits and vegetables modulate tau hyperphosphorylation and beta amyloid aggregation in animal models of Alzheimer disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-10
Biomarker-guided clustering of Alzheimer's disease clinical syndromes
50/100 ✓ Peer-reviewed Risk factors Neurobiology of Aging
Key finding: We found 5 distinct clusters (sizes: N = 38, 16, 24, 14, and 21) whose composition was independent of phenotypical groups. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-09-10
Novel Method for Rapid Assessment of Cognitive Impairment Using High-Performance Eye-Tracking Technology
53/100 ✓ Peer-reviewed Cognitive tests and assessment Scientific reports
Key finding: Accumulating evidence suggests that early diagnosis and timely intervention can delay cognitive decline. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-10
New evidence on the management of Lewy body dementia
71/100 ✓ Peer-reviewed Risk factors The Lancet. Neurology
Key finding: Treatments can address one symptom but worsen another, which makes disease management difficult. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-09
Ageing as a risk factor for neurodegenerative disease
38/100 ✓ Peer-reviewed Disease mechanisms Nature reviews. Neurology
Key finding: Few or no effective treatments are available for ageing-related neurodegenerative diseases, which tend to progress in an irreversible manner and are associated with large socioeconomic and personal costs.
Full summary, score breakdown and related studies → Original source
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2019-09-09
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity
41/100 ✓ Peer-reviewed Genetics Nature neuroscience
Key finding: We determined the mitochondrial proteome of the three major cerebellar cell types (Purkinje cells, granule cells and astrocytes) and identified hundreds of mitochondrial proteins that are differentially regulated. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-09
Quantitative gait, cognitive decline, and incident dementia: The Rotterdam Study
42/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Poor gait has recently emerged as a potential prodromal feature of cognitive decline and dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-08
Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain pathology (Zurich, Switzerland)
Key finding: Both spine morphology and the synaptic plasticity that supports learning depend upon the actin cytoskeleton, suggesting that disturbances in actin regulatory signaling might underlie spine defects in both disorders. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-06
Atrial Fibrillation Genetics Update: Toward Clinical Implementation
39/100 ✓ Peer-reviewed Genetics Frontiers in cardiovascular medicine
Key finding: AF is associated with increased risk of stroke, dementia, heart failure, and death.
Full summary, score breakdown and related studies → Original source
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2019-09-06
Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease
59/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Plasma lipocalin-2 levels were higher in preclinical AD compared with control subjects and associated with cerebrospinal fluid amyloid-beta42 levels but not cerebrospinal fluid tau or phosphorylated-tau181 levels. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-06
The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer's Dementia
41/100 ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience
Key finding: However, since amyloid-directed treatments have shown no relevant beneficial results other theories have been postulated to explain the origin of the pathology.
Full summary, score breakdown and related studies → Original source
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2019-09-06
Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression
59/100 ✓ Peer-reviewed Mild cognitive impairment Cell research
Key finding: The brain-infiltrated peripheral Th1 immune cells are associated with the M1 microglia activation, contributing to AD-associated neuroinflammation. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-06
Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial
69/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Ladostigil was safe and well tolerated but did not delay progression to dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-09-05
Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life
38/100 ✓ Peer-reviewed Long-term cohort studies JCI insight
Key finding: Here, we report evidence from mouse and human studies that this goal can be achieved by maintaining optimal hydration throughout life. +3 more findings
Full summary, score breakdown and related studies → Original source
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