Newest studies

Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis

66/100 ✓ Peer-reviewed Brain scans and imaging Ophthalmology

Key finding: Topic OCT is a noninvasive tool to measure specific retinal layers in the eye. +2 more findings

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Prediabetes and diabetes accelerate cognitive decline and predict microvascular lesions: A population-based cohort study

67/100 ✓ Peer-reviewed Hippocampus size on brain scans Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Diabetes and prediabetes accelerate cognitive decline and might predict microvascular lesions among dementia-free older adults. +3 more findings

• Brain Scans
• Risk Factors

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Vision Impairment and Risk of Dementia: Findings from the English Longitudinal Study of Ageing

53/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society

Key finding: Our study confirms and extends findings from other countries, demonstrating cross-sectional associations between moderate and poor self-rated vision and dementia in England in all participants aged 50 and older and longitudinally over an 11-year period in those aged 50 to 69. +2 more findings

• Risk Factors

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Sex Differences in Neuropathology and Cognitive Behavior in APP/PS1/tau Triple-Transgenic Mouse Model of Alzheimer's Disease

42/100 ✓ Peer-reviewed Inflammation and the immune system Neuroscience bulletin

Key finding: A sex difference in the prevalence of AD has been noted, while sex differences in the cerebral pathology and relevant molecular mechanisms are not well clarified. +3 more findings

• Brain Biology
• Digital Tools

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Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review

51/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Machine learning does not differentiate clinically relevant disease categories yet. +1 more finding

• Digital Tools
• Brain Scans

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Size matters: Grey matter brain reserve predicts executive functioning in the elderly

45/100 ✓ Peer-reviewed Risk factors Neuropsychologia

Key finding: All GM volumes - most notably of global GM - were significantly associated with TMT B independently of GM atrophy (ß = -0.201 to -0.275, p = 0.001-0.012).

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Structural neuroimaging as clinical predictor: A review of machine learning applications

41/100 ✓ Peer-reviewed Digital health tools NeuroImage. Clinical

Key finding: In this paper, we provide an extensive overview of machine learning techniques applied to structural magnetic resonance imaging (MRI) data to obtain clinical classifiers. +3 more findings

• Brain Scans
• Digital Tools

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Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

38/100 ✓ Peer-reviewed Disparities Chemical reviews

Key finding: Metal ion dyshomeostasis, proteopathy, oxidative stress, and neurotransmitter deficiencies are pathological features shared across multiple neurodegenerative disorders. +4 more findings

• Other Dementias
• Treatments
• Health Equity

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The Contribution of Tau, Amyloid-Beta and Alpha-Synuclein Pathology to Dementia in Lewy Body Disorders

48/100 ✓ Peer-reviewed Caregiving Journal of Alzheimer's disease & Parkinsonism

Key finding: The majority of patients with Parkinson's Disease develop Dementia (PDD) in late stages of the disease and have widespread neocortical distribution of alpha-synuclein pathology at autopsy, compared with PD without dementia, in which neocortical synuclein pathology is less prevalent. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Evaluation of 18F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain

44/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: The plasma reference graphical analysis appeared to be the optimal method of quantification for 18 F-RO-948, yielding strictly time-consistent values of distribution volume and distribution volume ratio at 90 min against the analyses at 120 and 200 min. +3 more findings

• Brain Scans

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A pharmacoeconomic evaluation of cholinesterase inhibitors and memantine for the treatment of Alzheimer's disease

68/100 ✓ Peer-reviewed Treatments Expert opinion on pharmacotherapy

Key finding: Alzheimer's disease (AD) results in progressively worsening cognitive decline, leading to loss of functional ability, behavior/mood disturbances, institutionalization, and death. +2 more findings

• Treatments

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Neural correlates of liraglutide effects in persons at risk for Alzheimer's disease

66/100 ✓ Peer-reviewed Drug development Behavioural brain research

Key finding: Insulin resistance (IR) is a metabolic state preceding development of type 2 diabetes (DM2), cardiovascular disease, and neurodegenerative disorders, including Alzheimer's Disease (AD). +1 more finding

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Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

41/100 ✓ Peer-reviewed Inflammation and the immune system Molecular neurodegeneration

Key finding: This study proposes TLR2 immunotherapy as a novel therapeutic strategy for synucleinopathies of the aging population. +1 more finding

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

53/100 ✓ Peer-reviewed Lewy body dementia Molecular cell

Key finding: We establish that TDP-43 non-covalently binds to PAR via PAR-binding motifs embedded within its nuclear localization sequence. +4 more findings

• Brain Biology
• Other Dementias

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Dementia, Alzheimer's Disease, and Mortality after Hemodialysis Initiation

56/100 ✓ Peer-reviewed Disparities Clinical journal of the American Society of Nephrology : CJASN

Key finding: Older patients on hemodialysis are at substantial risk of diagnosis with dementia and Alzheimer's disease, and carrying these diagnoses is associated with a twofold higher mortality. +3 more findings

• Risk Factors

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miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline

39/100 ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

Key finding: In this study, we showed that miR-34c overexpression in hippocampal neurons negatively regulated dendritic length and spine density.

• Brain Biology

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Wine: An Aspiring Agent in Promoting Longevity and Preventing Chronic Diseases

41/100 ✓ Peer-reviewed Prevention trials Diseases (Basel, Switzerland)

Key finding: Moderate wine intake, at 1⁻2 glasses per day as part of the Mediterranean diet, has been positively associated with human health promotion, disease prevention, and disease prognosis. +2 more findings

• Prevention
• Lifestyle

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Long-Term Cognitive Prognosis of Profoundly Deaf Older Adults After Hearing Rehabilitation Using Cochlear Implants

61/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society

Key finding: MCI is highly prevalent in older adults with profound hearing loss. +2 more findings

• Early Stage

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Trends in dementia diagnosis rates in UK ethnic groups: analysis of UK primary care data

66/100 ✓ Peer-reviewed Disparities Clinical epidemiology

Key finding: People from the black ethnic group had a higher incidence of dementia diagnosis and those from the Asian ethnic group had lower incidence compared with the white ethnic group. +4 more findings

• Health Equity
• Diagnosis
• Risk Factors

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A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

67/100 ✓ Peer-reviewed Genetics Scientific data

Key finding: We initiated the systematic profiling of the dorsolateral prefrontal cortex obtained from a subset of autopsied individuals enrolled in the Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP), which are jointly designed prospective studies of aging and dementia with detailed, longitudinal cognitive phenotyping during life and a quantitative, structured neuropathologic examination after death. +4 more findings

• Genetics

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Psychosocial interventions for Alzheimer's disease cognitive symptoms: a Bayesian network meta-analysis

78/100 ✓ Peer-reviewed Prevention trials BMC geriatrics

Key finding: Our study confirmed the effectiveness of psychosocial interventions for improving cognition or slowing down the progression of cognitive impairment in AD patients and recommended several interventions for clinical practice. +2 more findings

• Lifestyle

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Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results

67/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's research & therapy

Key finding: The SCIENCe study confirms that SCD is a heterogeneous group, with preclinical AD and subthreshold psychiatric features. +3 more findings

• Early Stage

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Classification and Prediction of Brain Disorders Using Functional Connectivity: Promising but Challenging

41/100 ✓ Peer-reviewed Digital health tools Frontiers in neuroscience

Key finding: In terms of model building, we include traditional classifiers as well as more recently applied deep learning methods. +4 more findings

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Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

41/100 ✓ Peer-reviewed Genetics The Journal of experimental medicine

Key finding: Using this approach in models of amyloidosis, tauopathy, and aging, we revealed a common set of alterations and identified a central APOE-driven network that converged on CCL3 and CCL4 across all conditions. +2 more findings

• Genetics
• Brain Biology

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Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study

64/100 ✓ Peer-reviewed Caregiving The Lancet. Neurology

Key finding: APOE ε4 count was associated with higher TDP-43 proteinopathy stage (odds ratio [OR] 2·0, 95% CI 1·6-2·6; p=1·9 × 10 -9 ) and TDP-43 burden (0·40, 0·28-0·52; p=1·2 × 10 -10 ). +2 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source