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Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults
Bowman GL, Dayon L, Kirkland R, Wojcik J, Peyratout G, Severin IC, Henry H, Oikonomidi A et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018-08-14
Topic: Risk, prevention and care in population studies
Introduction Blood-brain barrier (BBB) breakdown is observed in older versus younger adults and in late-onset Alzheimer's disease versus age-matched controls, but its causes and consequences in aging are unclear. We tested the hypothesis that BBB breakdown is associated with cognitive decline and inflammation in nondemented elders. Methods Cerebrospinal fluid and serum inflammatory markers were measured using sandwich immunoassays in 120 subjects.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Bowman, G. L., Dayon, L., Kirkland, R., Wojcik, J., Peyratout, G., Severin, I. C., et al. (2018). Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1016/j.jalz.2018.06.2857
Vancouver
Bowman GL, Dayon L, Kirkland R, Wojcik J, Peyratout G, Severin IC, et al. Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2018. doi:10.1016/j.jalz.2018.06.2857. PMID: 30120040.
BibTeX
@article{bowman2018-30120040,
author = {Bowman, G. L. and Dayon, L. and Kirkland, R. and Wojcik, J. and Peyratout, G. and Severin, I. C. and Henry, H. and Oikonomidi, A. and others},
title = {{Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2018},
doi = {10.1016/j.jalz.2018.06.2857},
pmid = {30120040},
url = {https://doi.org/10.1016/j.jalz.2018.06.2857}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- We tested the hypothesis that BBB breakdown is associated with cognitive decline and inflammation in nondemented elders.
- Methods Cerebrospinal fluid and serum inflammatory markers were measured using sandwich immunoassays in 120 subjects.
- Least Absolute Shrinkage and Selection Operator-logistic regression selected cerebrospinal fluid and serum signatures that best classified BBB impairment defined by the cerebrospinal fluid albumin index ≥9.
- Linear regression examined changes in Clinical Dementia Rating sum of boxes as a function of BBB integrity at baseline.
Why it matters
In 120 nondemented elders, this study tested whether blood-brain barrier breakdown is associated with cognitive decline and inflammation. It is an observational study of associations and does not show that treating barrier breakdown prevents or cures Alzheimer's disease.
Study details
- Participants120
- Effect size13.5%
- Evidence strengthLow
How this study scored 58/100
Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 120 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 298 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 29.8 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 4 / 6 | Cited 8.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 11 other studies in this library |
| Still being cited | 3 / 4 | Cited 101 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Julius Popp: h-index 59 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | École Polytechnique Fédérale de Lausanne: institution h-index 1,186 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30120040) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.jalz.2018.06.2857
- PubMed: 30120040
- Original source →
- Free full text: Infoscience (Ecole Polytechnique Fédérale de Lausanne) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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