Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 13,601–13,625 of 27,380 studies, newest first · page 545 of 1096.
October 2018 24
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2018-10-05
CSF sAPPβ, YKL-40, and NfL along the ALS-FTD spectrum
55/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: We found increased levels of YKL-40 and decreased levels of sAPPβ in both FTD and ALS groups compared to controls. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-10-04
Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
45/100 ✓ Peer-reviewed Genetics Molecular neurodegeneration
Key finding: Further analysis of the AD brain proteome will continue to yield new insights into the biological basis of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-04
Plasma Amyloid as Prescreener for the Earliest Alzheimer Pathological Changes
64/100 ✓ Peer-reviewed Mild cognitive impairment Annals of neurology
Key finding: Plasma Abeta42/Abeta40 ratio has potential as a prescreener to identify Alzheimer pathological changes in cognitively normal individuals with SCD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-10-03
Impact of air pollution on depression and suicide
39/100 ✓ Peer-reviewed Risk factors International journal of occupational medicine and environmental health
Key finding: There are many risk factors for these conditions, most important of which are the social situation or chronic diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-03
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau
48/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular psychiatry
Key finding: Using transgenic or viral approaches, we characterized in mice the effects of TYROBP deficiency on the phenotypic and pathological evolution of tauopathy. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-03
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden
48/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular psychiatry
Key finding: We previously constructed a probabilistic causal network model of sporadic LOAD and identified TYROBP/DAP12, encoding a microglial transmembrane signaling polypeptide and direct adapter of TREM2, as the most robust key driver gene in the network. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-02
The UK Biobank resource with deep phenotyping and genomic data
63/100 ✓ Peer-reviewed Long-term cohort studies Nature
The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data collected on approximately 500,000 individuals from across the United Kingdom, aged between 40 and 69 at recruitment.
Full summary, score breakdown and related studies → Original source
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2018-10-02
Lifetime risk of common neurological diseases in the elderly population
54/100 ✓ Peer-reviewed Long-term cohort studies Journal of neurology, neurosurgery, and psychiatry
Key finding: Within the prospective population-based Rotterdam Study, we studied lifetime risk of dementia, stroke and parkinsonism between 1990 and 2016. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
Multi-Modality Cascaded Convolutional Neural Networks for Alzheimer's Disease Diagnosis
50/100 ✓ Peer-reviewed Digital health tools Neuroinformatics
Key finding: Experimental results show that the proposed method achieves an accuracy of 93.26% for classification of AD vs.
Full summary, score breakdown and related studies → Original source
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2018-10-01
Association of Cognition and Age-Related Hearing Impairment in the English Longitudinal Study of Ageing
52/100 ✓ Peer-reviewed Risk factors JAMA otolaryngology-- head & neck surgery
Key finding: Although hearing loss and cognition are linked, untreated hearing loss drives the association. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
Using virtual reality in medical education to teach empathy
41/100 ✓ Peer-reviewed Risk factors Journal of the Medical Library Association : JMLA
Key finding: VR immersion training is an effective teaching method to help medical and health professions students develop empathy and is a budding area for library partnerships. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-10-01
The Meningeal Lymphatic System: A New Player in Neurophysiology
38/100 ✓ Peer-reviewed Tau biomarkers Neuron
Key finding: Of particular relevance is its participation in diseases associated with protein accumulation and aggregation in the brain, such as Alzheimer's disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-10-01
Higher Aortic Stiffness Is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults
47/100 ✓ Peer-reviewed Vascular contributions Circulation
Key finding: Among participants with normal cognition, higher aortic PWV related to lower frontal lobe CBF (β=-0.43; P=0.04) and higher CVR in the whole brain (β=0.11; P=0.02), frontal lobes (β=0.12; P<0.05), temporal lobes (β=0.11; P=0.02), and occipital lobes (β=0.14; P=0.01). +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
Quality of dying and quality of end-of-life care of nursing home residents in six countries: An epidemiological study
45/100 ✓ Peer-reviewed End-of-life care Palliative medicine
Key finding: The quality of dying and quality of end-of-life care in nursing homes in the countries studied are not optimal. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging
48/100 ✓ Peer-reviewed Disease mechanisms JAMA neurology
Key finding: Ten participants with AD (5 male and 5 female; mean [SD] age, 72.7 [6.3] years; 10 [100%] β-amyloid positive) were compared with 11 participants who were cognitively normal (5 male and 6 female; mean [SD] age, 72.9 [8.7] years; 11 [100%] β-amyloid negative). +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
Association of Retinal Neurodegeneration on Optical Coherence Tomography With Dementia: A Population-Based Study
66/100 ✓ Peer-reviewed Long-term cohort studies JAMA neurology
Key finding: Retinal structures may serve as a biomarker for dementia, but longitudinal studies examining this link are lacking. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease
55/100 ✓ Peer-reviewed TREM2 and immune genetics Brain : a journal of neurology
Key finding: However, the spatiotemporal pattern of white matter changes preceding dementia symptoms in Alzheimer's disease remains unclear, largely due to the inherent diagnostic uncertainty in the preclinical phase and increased risk of confounding age-related vascular disease and stroke in late-onset Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
Hearing Loss Treatment in Older Adults With Cognitive Impairment: A Systematic Review
56/100 ✓ Peer-reviewed Digital health tools Journal of speech, language, and hearing research : JSLHR
Key finding: Based on the systematic review, evidence suggests that treating hearing loss in persons with cognitive impairment can have benefits to communication and quality of life. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
Communication Difficulties as a Result of Dementia
43/100 ✓ Peer-reviewed Digital health tools Materia socio-medica
Key finding: Communication for people with dementia and with people with dementia for all persons involved in care (including family members, medical staff and therapists, and members of the community) can be very challenging. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
Basic characteristics and representativeness of the German Disease Analyzer database
56/100 ✓ Peer-reviewed How common it is International journal of clinical pharmacology and therapeutics
Key finding: There was a good agreement of the incidence or prevalence of major chronic diseases in the outpatient DA with German reference data.
Full summary, score breakdown and related studies → Original source
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2018-10-01
Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications
53/100 ✓ Peer-reviewed Caregiving Nature reviews. Endocrinology
Key finding: In the majority of patients, the cognitive phenotype is probably defined by multiple aetiologies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set
73/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer disease and associated disorders
Key finding: The results from utilization of the UDS highlight the possibility for numerous research institutions to successfully collaborate, produce, and use standardized data collection instruments for over a decade. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-10-01
Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline: A Study Using Optical Coherence Tomography
59/100 ✓ Peer-reviewed Prevention and risk JAMA neurology
Key finding: A thinner RNFL was associated with worse cognitive performance on baseline assessment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-10-01
A cluster randomized controlled trial to test the feasibility and preliminary effectiveness of a family dementia caregiver intervention in Vietnam: The REACH VN study protocol
58/100 ✓ Peer-reviewed Treatments Medicine
Key finding: This is the first study to test community-based family dementia caregiver intervention in Vietnam.
Full summary, score breakdown and related studies → Original source
September 2018 1
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2018-09-30
Cerebral Small Vessel Disease: A Review Focusing on Pathophysiology, Biomarkers, and Machine Learning Strategies
41/100 ✓ Peer-reviewed Digital health tools Journal of stroke
Key finding: Application of neural networking, machine learning and deep learning in image processing have increased significantly for correct severity of cSVD.
Full summary, score breakdown and related studies → Original source
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