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53/100

✓ Peer-reviewed alzhub usefulness score 53 out of 100. Long-term cohort studies

Topic: Brain proteins, microglia and lab models

Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes might represent useful instruments for the prediction of cognitive decline. The primary objective was to determine the predictive value of hippocampus and basal forebrain volumes for global and domain specific cognitive decline in AD dementia during cholinergic treatment.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Teipel, S. J., Cavedo, E., Hampel, H., Grothe, M. J., & Alzheimer's Disease Neuroimaging Initiative. (2018). Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors. Frontiers in neurology. https://doi.org/10.3389/fneur.2018.00642

Vancouver

Teipel SJ, Cavedo E, Hampel H, Grothe MJ, Alzheimer's Disease Neuroimaging Initiative. Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors. Frontiers in neurology. 2018. doi:10.3389/fneur.2018.00642. PMID: 30158893.

BibTeX

@article{teipel2018-30158893,
  author  = {Teipel, S. J. and Cavedo, E. and Hampel, H. and Grothe, M. J. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors}},
  journal = {Frontiers in neurology},
  year    = {2018},
  doi     = {10.3389/fneur.2018.00642},
  pmid    = {30158893},
  url     = {https://doi.org/10.3389/fneur.2018.00642}
}

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Key findings

Structural MRI markers such as hippocampus or basal forebrain volumes might represent useful instruments for the prediction of cognitive decline.
The primary objective was to determine the predictive value of hippocampus and basal forebrain volumes for global and domain specific cognitive decline in AD dementia during cholinergic treatment.
Methods: We used MRI and cognitive data from 124 patients with the clinical diagnosis of AD dementia, derived from the ADNI-1 cohort, who were on standard of care cholinesterase inhibitor treatment during a follow-up period between 0.4 and 3.1 years.
We used linear mixed effects models with cognitive function as outcome to assess the main effects as well as two-way interactions between baseline volumes and time controlling for age, sex, and total intracranial volume.

Why it matters

In 124 patients with Alzheimer's dementia taking cholinesterase inhibitors, the size of the basal forebrain (but not the hippocampus) predicted later decline in overall thinking. This suggests a brain scan measure might help predict how someone will do on this type of treatment, but it does not show that the treatment itself changes the disease course.

Study details

Participants124
Evidence strengthModerate

How this study scored 53/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 51 of the 96 points we could judge it on, which is 53 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in neurology)
Journal's citation record	2 / 4	Frontiers in Neurology: journal h-index 162 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	2 / 4	124 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 49 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	4.9 citations a year over 10 year(s) since 2018
Impact for its field and year	3 / 6	Cited 3.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	2 / 4	Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	3 / 3	Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 12 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 30158893)
Free to read	2 / 2	Free to read
Points	51 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 51 of the 96 points we could judge it on is 53 out of 100.
Total	53 / 100	—

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