Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,226–26,250 of 27,380 studies, newest first · page 1050 of 1096.
February 1997 6
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1997-02-01
Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease
48/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: In this report, levels of APP and its amyloidogenic metabolites were measured in brain regions of transgenic mice between 4 and 18 months of age. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-02-01
Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience letters
Key finding: HDC and ChAT activity were reduced in brains of both DS and Alzheimer patients versus control patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-02-01
Atrial fibrillation and dementia in a population-based study. The Rotterdam Study
60/100 ✓ Peer-reviewed Risk factors Stroke
Key finding: Dementia and subtypes Alzheimer's disease and vascular dementia may be related to atrial fibrillation even if no clinical stokes have occurred. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-02-01
Hereditary frontotemporal dementia is linked to chromosome 17q21-q22: a genetic and clinicopathological study of three Dutch families
46/100 ✓ Peer-reviewed Digital health tools Annals of neurology
Key finding: The mean age of onset varied significantly between families. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-02-01
Risk of dementia among persons with diabetes mellitus: a population-based cohort study
62/100 ✓ Peer-reviewed Prevention and risk American journal of epidemiology
Key finding: It is unclear whether persons with diabetes are at increased risk for dementia, including Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-02-01
Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex
39/100 ✓ Peer-reviewed Genetics American journal of human genetics
Key finding: When compared to the APOE epsilon3 allele, an increased risk associated with the APOE epsilon4 allele (odds ratio [OR] [epsilon4] = 2.7 with 95% confidence interval [CI] = 2.0-3.6; P 79 years were significantly lower than those from the age groups 60-79 years.
Full summary, score breakdown and related studies → Original source
January 1997 19
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1997-01-01
An Inventory to Assess Activities of Daily Living for Clinical Trials in Alzheimerʼs Disease
43/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer Disease & Associated Disorders
Key finding: Controls performed virtually all ADL items optimally at baseline and at 12 months. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
ApoE-4 and Age at Onset of Alzheimer's Disease
48/100 ✓ Peer-reviewed Genetics Neurology
Key finding: ApoE-4 was strongly associated with AD in this sample (allele frequency = 0.46 vs. 0.14 in controls, p < 0.000001). +4 more findings
Full summary, score breakdown and related studies → Original source
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1997 year only
Alzheimer caregiver stress: basal natural killer cell activity, pituitary-adrenal cortical function, and sympathetic tone
45/100 ✓ Peer-reviewed Caregiving Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
Key finding: As compared to controls, the Alzheimer caregivers had similar levels of NK activity and of basal plasma neuroendocrine hormones and sympathetic measures. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Accuracy of the clinical diagnosis of corticobasal degeneration: a clinicopathologic study
43/100 ✓ Peer-reviewed Digital health tools Neurology
Key finding: The neurologists' clinical diagnoses were compared with clinicopathologic diagnoses for sensitivity, specificity, and positive predictive values at first and last clinic visits. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Variations in circadian rhythms of activity, sleep, and light exposure related to dementia in nursing-home patients
36/100 ✓ Peer-reviewed Health systems and care delivery Sleep
Key finding: Severely demented patients slept more both at night and during the day, but there were no significant differences in the number of awakenings during the night or in the number of naps during the day when compared to the composite group of moderate, mild, or no-dementia patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-01-01
Visual impairment in nursing home residents: the Blue Mountains Eye Study
40/100 ✓ Peer-reviewed Risk factors The Medical journal of Australia
Key finding: These data confirm earlier reports of a substantial number of treatable eye diseases, particularly advanced cataract, in nursing home residents, and indicate a need for increased surveillance of these communities. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Central cholinergic systems and cognition
36/100 ✓ Peer-reviewed Risk factors Annual review of psychology
Key finding: We also suggest that nucleus basalis-amygdala cholinergic projections have a role in the retention of affective conditioning while brainstem cholinergic projections to the thalamus and midbrain dopamine neurons affect basic arousal processes (e.g. sleep-wake cycle) and behavioral activation, respectively.
Full summary, score breakdown and related studies → Original source
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1997-01-01
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
41/100 ✓ Peer-reviewed Risk genes beyond APOE Nature medicine
Key finding: In the transfected cells, PS1 and PS2 mutations caused a highly significant increase in A beta 42 secretion in all mutant clones. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-01-01
Herpes simplex virus type 1 in brain and risk of Alzheimer's disease
52/100 ✓ Peer-reviewed Genetics Lancet (London, England)
Key finding: By multiple logistic regression, the APOE-epsilon 4 allele frequency was significantly higher in the patients positive for HSV1 in brain than in the HSV1-negative AD group, the HSV1-positive non-AD group, or the HSV1-negative non-AD group (52.8% vs 10.0%, 3.6%, and 6.3%, respectively). +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Chronic alcohol consumption does not cause hippocampal neuron loss in humans
36/100 ✓ Peer-reviewed Hippocampus size on brain scans Hippocampus
Key finding: High alcohol consumption for long periods of time causes significant hippocampal neurodegeneration in rodents. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
The spectrum of hippocampal sclerosis: a quantitative magnetic resonance imaging study
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Annals of neurology
Key finding: A combination of hippocampal T2 mapping, hippocampal volume measurement corrected for intracranial volume, and inspection of hippocampal morphology on a hippocampal volume distribution graph compared with a control graph revealed previously undetected forms of bilateral hippocampal sclerosis and four false-positive diagnoses of hippocampal sclerosis made on visual inspection of the scans. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Hippocampal volume in normal aging and traumatic brain injury
43/100 ✓ Peer-reviewed Hippocampus size on brain scans AJNR. American journal of neuroradiology
Key finding: Volumetric measures in a group of patients with traumatic brain injury who had received MR imaging 3 months or less after injury were compared with measurements in other patients in the chronic phase of recovery. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse--a preliminary report
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: The findings were significant after controlling for alcohol, age, and education, with multiple linear regression. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-01-01
Which clinical features differentiate progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) from related disorders? A clinicopathological study
47/100 ✓ Peer-reviewed Clinical safety Brain : a journal of neurology
Key finding: Supranuclear vertical gaze palsy, gait instability and the absence of delusions distinguished PSP from diffuse Lewy body disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-01-01
Major and minor depression in Alzheimer's disease: prevalence and impact
41/100 ✓ Peer-reviewed Clinical safety The Journal of neuropsychiatry and clinical neurosciences
Key finding: Distribution of depression scores revealed three patient groups: very few depressive symptoms (51%), minor depression (27%), and major depression (22%). +3 more findings
Full summary, score breakdown and related studies → Original source
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1997 no date recorded — placed by publication year
Oxidative Stress Hypothesis in Alzheimer's Disease
52/100 ✓ Peer-reviewed Disease mechanisms Free Radical Biology and Medicine
Key finding: The direct evidence supporting increased oxidative stress in AD is: (1) increased brain Fe, Al, and Hg in AD, capable of stimulating free radical generation; (2) increased lipid peroxidation and decreased polyunsaturated fatty acids in the AD brain, and increased 4-hydroxynonenal, an aldehyde product of lipid peroxidation in AD ventricular fluid; (3) increased protein and DNA oxidation in the AD brain; (4) diminished energy metabolism and decreased cytochrome c oxidase in the brain in AD; (5) advanced glycation end products (AGE), malondialdehyde, carbonyls, peroxynitrite, heme oxygenase-1 and SOD-1 in neurofibrillary tangles and AGE, heme oxygenase-1, SOD-1 in senile plaques; and (6) studies showing that amyloid beta peptide is capable of generating free radicals. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997 no date recorded — placed by publication year
Development of Cognitive Instruments for Use in Clinical Trials of Antidementia Drugs
45/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer Disease & Associated Disorders
The cognitive assessment protocol of the Alzheimer's Disease Cooperative Study (ADCS) was designed to evaluate the reliability and validity of cognitive assessment measures that might be valuable additions to the Alzheimer's Disease Assessment Scale (ADAS) or other concise batteries used in antidementia drug trials.
Full summary, score breakdown and related studies → Original source
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1997 no date recorded — placed by publication year
Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change. The Alzheimer's Disease Cooperative Study
44/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer Disease & Associated Disorders
This article reports the development and psychometric properties of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC).
Full summary, score breakdown and related studies → Original source
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1997 no date recorded — placed by publication year
Information Technology and the Economic Performance of the Grocery Store Industry
13/100 ⚠ Preprint — not yet peer-reviewed Risk factors Not indexed
Key finding: The grocery store industry is one of the U.S. industries that are increasing their sophistication in information technology. +4 more findings
Full summary, score breakdown and related studies → Original source
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