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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 13,576–13,600 of 27,380 studies, newest first · page 544 of 1096.

October 2018 25

  1. 2018-10-15

    Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: This is the first study to show serum-based BA metabolites are associated with "A/T/N" AD biomarkers, providing further support for a role of BA pathways in AD pathophysiology. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2018-10-15

    Effects of the Namaste Care Family programme on quality of life of nursing home residents with advanced dementia and on family caregiving experiences: study protocol of a cluster-randomised controlled trial

    ✓ Peer-reviewed End-of-life care BMJ open

    Key finding: Quality of life of people with advanced dementia living in nursing homes is often suboptimal.

    Full summary, score breakdown and related studies → Original source

  3. 2018-10-15

    Distinct cytokine profiles in human brains resilient to Alzheimer's pathology

    ✓ Peer-reviewed Disease mechanisms Neurobiology of disease

    Key finding: Moreover, they exhibit decreased astrocyte and microglial activation markers GFAP and CD68, suggesting that a suppressed neuroinflammatory response may be implicated in human brain resilience to Alzheimer's pathology. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2018-10-15

    Identification of a simple and novel cut-point based CSF and MRI signature for predicting Alzheimer’s disease progression that reinforces the 2018 NIA-AA research framework

    ✓ Peer-reviewed Tau biomarkers Journal of Alzheimer's disease : JAD

    Key finding: Data from the ADNI (AD neuroimaging initiative) database can be utilized to identify diagnostic signatures for predicting AD progression, and to determine the utility of this NIA-AA research framework. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2018-10-15

    Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

    ✓ Peer-reviewed Digital health tools Nature communications

    Key finding: The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories.

    Full summary, score breakdown and related studies → Original source

  6. 2018-10-14

    Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau

    ✓ Peer-reviewed Drug development Alzheimer's & dementia (New York, N. Y.)

    Key finding: The antibody C10.2 bound specifically to pS396-tau with an IC50 of 104 pM and detected preferentially hyperphosphorylated tau aggregates from AD brain with an IC50 of 1.2 nM. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2018-10-13

    Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

    ✓ Peer-reviewed Hippocampus size on brain scans Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: (1) Data-driven AD progression models supported multifactorial interactions rather than a linear cascade of events. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2018-10-13

    Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer's dementia

    ✓ Peer-reviewed Disease mechanisms Ageing research reviews

    Key finding: Emerging evidence indicates that moderate intensity aerobic exercise is positively correlated with cognitive function and memory. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2018-10-13

    Misidentification of Dementia in Medicare Claims and Related Costs

    ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society

    Key finding: Misidentification of dementia in Medicare claims is common. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2018-10-12

    Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study

    ✓ Peer-reviewed Disease mechanisms Alzheimer's research & therapy

    Key finding: The maximal tolerated dose of PQ912 has been identified and the results support future studies at still lower doses reaching > 50% target occupancy, a longer up-titration phase to potentially induce adaptation and longer treatment periods to confirm the early signals of efficacy as seen in this study. +3 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2018-10-12

    Leisure-time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities Study

    ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: We tested the hypotheses that higher levels of and persistence of midlife leisure-time physical activity (LTPA) are associated long-term with lower cognitive decline and less incident dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2018-10-12

    Declining Incident Dementia Rates Across Four Population-Based Birth Cohorts

    ✓ Peer-reviewed How common it is The Journals of Gerontology: Series A (Biological Sciences and Medical Sciences)

    Key finding: Incidence rate ratio fell progressively across birth cohorts, down to 0.233 (95% CI 0.121-0.449) for the 1932-1941 cohort vs the 1902-1911 reference cohort +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2018-10-11

    Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients

    ✓ Peer-reviewed Treatments Clinical interventions in aging

    Key finding: In this review, we discuss 1) the efficacy of donepezil and its comparison with other AChEIs or memantine, 2) the therapeutic responses to donepezil and its influencing factors, and 3) the safety and tolerability of donepezil in Chinese patients with different stages of AD and amnestic mild cognitive impairment, and further compare the similarities and differences of the results between Chinese studies and previous Western studies that predominantly enrolled Caucasian subjects.

    Full summary, score breakdown and related studies → Original source

  14. 2018-10-11

    Tau protein aggregation is associated with cellular senescence in the brain

    ✓ Peer-reviewed Genetics Aging cell

    Key finding: NFT formation does not induce apoptosis (de Calignon, Spires-Jones, Pitstick, Carlson, & Hyman, 2009), which suggests that secondary mechanisms are driving toxicity. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2018-10-11

    Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis

    ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry

    Key finding: Serum NFL is increased in ALS in comparison to other conditions and can serve as diagnostic and prognostic biomarker. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2018-10-11

    ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

    ✓ Peer-reviewed Disease mechanisms Molecular neurodegeneration

    Key finding: Using Fisher's exact test, there was significant association of both ABI3_rs616338-T (OR = 1.41, p = 0.044) and PLCG2_rs72824905-G (OR = 0.56, p = 0.008) with AD. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2018-10-11

    Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody

    ✓ Peer-reviewed Drug development Structure (London, England : 1993)

    Key finding: Identification and characterization of the epitopes recognized by anti-tau antibodies might shed light on the molecular mechanisms of AD pathogenesis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2018-10-10

    Impact of support agreement between municipalities and convenience store chain companies on store staff's support activities for older adults

    ✓ Peer-reviewed Risk factors Health policy (Amsterdam, Netherlands)

    Key finding: The analysis showed that some staff activities increased significantly with the support agreement, such as corresponding or collaborating with community support centers (AOR = 3.40; 95% CI: 2.22 to 5.26), participating in role-playing programs for older adult care (AOR = 2.05; 95% CI: 1.01 to 4.26), and attending dementia support lectures (AOR = 18.21; 95% CI: 8.27 to 45.34). +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2018-10-10

    Regional amyloid accumulation and cognitive decline in initially amyloid-negative adults

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Our results indicate that assessing regional changes in amyloid, particularly in posterior cortical regions, can aid in the early detection of subclinical amyloid-related decline in episodic memory as early as middle age. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2018-10-06

    The Role of Tau Imaging in Parkinsonian Disorders

    ✓ Peer-reviewed Drug development Current neurology and neuroscience reports

    Key finding: Differential diagnosis of atypical Parkinson syndromes (APS) is difficult as clinical presentations may vary and as there is a strong overlap between disease entities.

    Full summary, score breakdown and related studies → Original source

  21. 2018-10-06

    Cause of Death and End-of-Life Experiences in Individuals with Dementia with Lewy Bodies

    ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

    Key finding: Study results highlight a critical need for better prognostic counseling and education for persons and families living with DLB. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2018-10-05

    Hearing treatment for reducing cognitive decline: Design and methods of the Aging and Cognitive Health Evaluation in Elders randomized controlled trial

    ✓ Peer-reviewed Risk factors Alzheimer's & dementia (New York, N. Y.)

    Key finding: When completed in 2022, Aging and Cognitive Health Evaluation in Elders study should provide definitive evidence of the effect of hearing treatment versus education control on cognitive decline in community-dwelling older adults with mild-to-moderate hearing impairment. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2018-10-05

    Obesity and Alzheimer's disease, does the obesity paradox really exist? A magnetic resonance imaging study

    ✓ Peer-reviewed Long-term cohort studies Oncotarget

    Key finding: Weight loss, which predates cognitive decline, might explain this obesity paradox on AD risk. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2018-10-05

    Racial and ethnic differences in trends in dementia prevalence and risk factors in the United States

    ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia (New York, N. Y.)

    Key finding: Racial disparities in dementia may be reduced by prevention and management of disease and promoting educational attainment among blacks and Hispanics. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2018-10-05

    Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers

    ✓ Peer-reviewed Genetics JAMA network open

    Key finding: Median (interquartile range) CRP levels increased with mean (SD) age (43.3 [9.6] years, 0.95 mg/L [0.40-2.35 mg/L] vs 59.1 [9.6] years, 2.04 mg/L [0.93-4.75 mg/L] vs 61.6 [9.5] years, 2.21 mg/L [1.05-5.12 mg/L]; P Conclusions and relevance In this study, peripheral chronic low-grade inflammation in participants with ApoE4 was associated with shortened latency for onset of AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →