Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 26,201–26,225 of 27,380 studies, newest first · page 1049 of 1096.
March 1997 15
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1997-03-01
A 5-year longitudinal study of the Mini-Mental State Examination in normal aging
50/100 ✓ Peer-reviewed Cognitive tests and assessment American journal of epidemiology
Key finding: This paper presents a 5-year longitudinal study of the MMSE score in a sample of 2,537 non-demented French community residents aged 65 years and older who were participants in the Paquid Study in 1988-1992. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease
43/100 ✓ Peer-reviewed Risk genes beyond APOE Genomics
Key finding: The presenilin genes encode integral membrane proteins with similar structures, which suggests that they may have closely related, but as yet unknown functions. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content
40/100 ✓ Peer-reviewed Risk genes beyond APOE The Biochemical journal
Key finding: In virtually all cell types the proteolytic processing of Alzheimer amyloid precursor protein (APP) to generate soluble APP (sAPP) is believed to occur at the plasma membrane or in its immediate proximity. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue
50/100 ✓ Peer-reviewed Risk genes beyond APOE Proceedings of the National Academy of Sciences of the United States of America
Key finding: PS2 was identified as a 50- to 55-kDa protein, which was cleaved to produce N-terminal fragments of 35-40 kDa and C-terminal fragments of 19-23 kDa. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor
44/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology
Key finding: A mutation at codon 139 in the presenilin 1 gene on chromosome 14 results in a methionine to valine substitution which cosegregates with the disease in these families. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Brain infarction and the clinical expression of Alzheimer disease. The Nun Study
62/100 ✓ Peer-reviewed How common it is JAMA
Key finding: These findings suggest that cerebrovascular disease may play an important role in determining the presence and severity of the clinical symptoms of AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Dietary antioxidants and other dietary factors in the etiology of Parkinson's disease
50/100 ✓ Peer-reviewed Disparities Movement disorders : official journal of the Movement Disorder Society
Key finding: It has been suggested that dietary antioxidants reduce Parkinson's disease (PD) risk by neutralizing free radicals, thus preventing injury to neurons in the substantia nigra. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Stroke, disability, and dementia: results of a population survey
55/100 ✓ Peer-reviewed Disparities Stroke
Key finding: In our population, the prevalence of stroke was higher than in previous studies. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-03-01
Behaviour disturbance and other predictors of carer burden in Alzheimer's disease
46/100 ✓ Peer-reviewed Caregiving International journal of geriatric psychiatry
Key finding: In this study increased carer burden was related independently to increased levels of patient behaviour disturbance and decreased levels of informal social support. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-03-01
Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease
55/100 ✓ Peer-reviewed Getting a diagnosis Neurobiology of aging
Key finding: We found hippocampal volume reductions of 14% for the MCI and 22% for the DAT group compared to the NL group. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-03-01
Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease
49/100 ✓ Peer-reviewed Getting a diagnosis The Journal of comparative neurology
Key finding: The mean total volume of the principal subdivisions of the hippocampal formation (fascia dentata, hilus, CA3-2, CA1, and subiculum) showed a negative correlation with age in normal subjects (r = -0.56, 2P < 0.05), and a 32% mean reduction in the AD group compared with controls (P < 0.001). +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective
47/100 ✓ Peer-reviewed Genetics JAMA
Key finding: Except for autosomal dominant early-onset families, genetic testing in asymptomatic individuals is unwarranted. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Why are stroke patients prone to develop dementia?
42/100 ✓ Peer-reviewed Genetics Journal of neurology
Key finding: We found three distinct factors that may explain the occurrence of dementia after a stroke. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Exploring the etiology of Alzheimer disease using molecular genetics
48/100 ✓ Peer-reviewed Genetics JAMA
Key finding: Mutations in each of these genes result in elevated levels of A beta42/43, a proteolytic processing fragment of APP that is deposited in brains of AD patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-03-01
Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation
66/100 ✓ Peer-reviewed Genetics JAMA
Key finding: The APOE epsilon4 allele is a genetic risk factor for dementia with stroke, including VaD and AD with CVD. +4 more findings
Full summary, score breakdown and related studies → Original source
February 1997 10
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1997-02-01
Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis
43/100 ✓ Peer-reviewed Brain scans and imaging American Journal of Psychiatry
Key finding: After the authors controlled for demographic characteristics and dementia severity, both estimates of premorbid intellectual ability were inversely correlated with cerebral metabolism in the prefrontal, pre-motor, and left superior parietal association regions. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-02-01
Frontal behavioral inventory: diagnostic criteria for frontal lobe dementia
43/100 ✓ Peer-reviewed Getting a diagnosis The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Key finding: The FBI appears to be a useful diagnostic instrument and a method to operate the behavioral criteria of FLD. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-02-01
Prevalence and incidence of health problems in people with intellectual disability
52/100 ✓ Peer-reviewed Risk factors Journal of intellectual disability research : JIDR
Key finding: Striking results included the reported high prevalence and incidence of visual and hearing impairment, which was even more pronounced in people with Down's syndrome than in people with intellectual disability resulting from other causes. +1 more finding
Full summary, score breakdown and related studies → Original source
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1997-02-01
Observation of metastable Abeta amyloid protofibrils by atomic force microscopy
36/100 ✓ Peer-reviewed Risk genes beyond APOE Chemistry & biology
Key finding: Abeta protofibrils are likely to be intermediates in the in vitro assembly of Abeta amyloid fibrils, but their in vivo role has yet to be determined.
Full summary, score breakdown and related studies → Original source
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1997-02-01
Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures
36/100 ✓ Peer-reviewed Biomarkers The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Mutant mice exhibited normal spatial learning in the Morris water maze and were not sensitive to systemic zinc or cadmium exposure. +4 more findings
Full summary, score breakdown and related studies → Original source
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1997-02-01
The risk factors and impact on survival of feeding tube placement in nursing home residents with severe cognitive impairment
55/100 ✓ Peer-reviewed Vascular contributions Archives of internal medicine
Key finding: There are specific risk factors associated with feeding tube placement in nursing home residents with severe cognitive impairment. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-02-01
Chronic histopathological consequences of fluid-percussion brain injury in rats: effects of post-traumatic hypothermia
40/100 ✓ Peer-reviewed Hippocampus size on brain scans Acta neuropathologica
Key finding: Significant hippocampal cell loss was found in the ipsilateral dentate hilar region of both TBI groups. +2 more findings
Full summary, score breakdown and related studies → Original source
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1997-02-01
Aggressive, socially disruptive and antisocial behaviour associated with fronto-temporal dementia
41/100 ✓ Peer-reviewed Clinical safety The British journal of psychiatry : the journal of mental science
Key finding: Degeneration of frontal and temporal lobes predisposes to antisocial behaviour. +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-02-01
CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
56/100 ✓ Peer-reviewed Inflammation and the immune system Nature
Key finding: T cell line-tropic (T-tropic) HIV-1 viruses use the chemokine receptor CXCR4 as a co-receptor, whereas macrophage-tropic (M-tropic) primary viruses use CCR5 (refs 2-6). +3 more findings
Full summary, score breakdown and related studies → Original source
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1997-02-01
Altered amyloid protein processing in platelets of patients with Alzheimer disease
45/100 ✓ Peer-reviewed Risk genes beyond APOE Archives of neurology
Key finding: Alternate cleavage products of intact 140- to 150-kd APPs in platelets include nonamyloidogenic 120- to 130-kd and 110-kd isoforms. +3 more findings
Full summary, score breakdown and related studies → Original source
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