Newest studies

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease

53/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

Key finding: The R47H variant of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) confers greatly increased risk for Alzheimer's disease (AD), reflective of a central role for myeloid cells in neurodegeneration. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

In-vivo staging of pathology in REM sleep behaviour disorder: a multimodality imaging case-control study

65/100 ✓ Peer-reviewed Risk factors The Lancet. Neurology

Key finding: Compared with controls, patients with idiopathic REM sleep behaviour disorder had decreased colonic 11 C-donepezil uptake (-0·322, 95% CI -0·112 to -0·531; p=0·0020), 123 I-MIBG heart:mediastinum ratio (-0·508, -0·353 to -0·664; p 18 F-DOPA uptake (Ki; -0·0023, -0·0009 to -0·0037; p=0·0013). +2 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source

Brain properties predict proximity to symptom onset in sporadic Alzheimer's disease

61/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

Key finding: Within the training set, individuals closer to or beyond their parent's symptom onset demonstrated reduced grey matter volume and altered functional connectivity, specifically in regions known to be vulnerable in Alzheimer's disease. +4 more findings

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Prevalence of dementia in mainland China, Hong Kong and Taiwan: an updated systematic review and meta-analysis

55/100 ✓ Peer-reviewed Prevention and risk International journal of epidemiology

Key finding: Geographical variation in dementia prevalence is confirmed in this update, whereas evidence on increasing trends is still insufficient.

Full summary, score breakdown and related studies → Original source

[Epidemiology of Alzheimer's disease and other dementias]

42/100 ✓ Peer-reviewed Prevention and risk Revista de neurologia

Key finding: The prevalence and incidence of dementia increase exponentially from the age of 65 onwards. +4 more findings

• Other Dementias
• Risk Factors

Full summary, score breakdown and related studies → Original source

Effects of Integrated Yoga Intervention on Psychopathologies and Sleep Quality Among Professional Caregivers of Older Adults With Alzheimer's Disease: A Controlled Pilot Study

54/100 ✓ Peer-reviewed Treatments Advances in mind-body medicine

Key finding: The present study showed the potential use of IY intervention in reducing stress, anxiety, and depression. +2 more findings

• Clinical Trials
• Lifestyle
• Caregiving

Full summary, score breakdown and related studies → Original source

Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype

60/100 ✓ Peer-reviewed Genetics Brain : a journal of neurology

Key finding: This work indicates that influence of the APOE gene on pathology can be detected starting in middle age.

• Genetics
• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Brain MRI analysis for Alzheimer's disease diagnosis using an ensemble system of deep convolutional neural networks

41/100 ✓ Peer-reviewed Digital health tools Brain informatics

Key finding: Recently, advanced deep learning techniques have successfully demonstrated human-level performance in numerous fields including medical image analysis.

• Digital Tools
• Brain Scans
• Diagnosis

Full summary, score breakdown and related studies → Original source

Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases

41/100 ✓ Peer-reviewed Treatments International journal of molecular sciences

Key finding: Because of its pleotropic actions on the central nervous system, including preferential binding to amyloid proteins, Cur is being touted as a promising treatment for age-related brain diseases. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types

38/100 ✓ Peer-reviewed Genetics Neuron

Key finding: Our study establishes a reference for human cell-type-specific changes associated with the APOE4 variant.

• Brain Biology
• Genetics

Full summary, score breakdown and related studies → Original source

The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons

44/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Stem cell reports

Key finding: Early-onset Alzheimer disease (AD)-like pathology in Down syndrome is commonly attributed to an increased dosage of the amyloid precursor protein (APP) gene. +4 more findings

• Down Syndrome
• Genetics
• Digital Tools

Full summary, score breakdown and related studies → Original source

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

42/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: The concentration of 124 I-RmAb158-scFv8D3, as measured in vivo with PET, increased with age and corresponded well with the ex vivo autoradiography and Aβ immunohistochemistry results. +4 more findings

• Brain Biology
• Brain Scans
• Clinical Trials

Full summary, score breakdown and related studies → Original source

Cerebral Imaging Markers of GBA and LRRK2 Related Parkinson's Disease and Their First-Degree Unaffected Relatives

41/100 ✓ Peer-reviewed Cognitive tests and assessment Brain topography

Key finding: Lower volumes among patients with PD compared to unaffected participants were detected in bilateral hippocampus, nucleus accumbens, caudate, thalamus, putamen and amygdala and the right pallidum (p = 0.016). +2 more findings

• Brain Scans
• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Amyloid positron emission tomography candidates may focus more on benefits than risks of results disclosure

65/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: Future research should examine whether minimizing drawbacks at the pre-imaging stage has adverse consequences on results disclosure. +4 more findings

• Clinical Trials
• Brain Scans

Full summary, score breakdown and related studies → Original source

Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals

39/100 ✓ Peer-reviewed Genetics Current genetic medicine reports

Key finding: The advent of genome-wide association studies (GWASs) constituted a breakthrough in our understanding of the genetic architecture of multifactorial diseases. +4 more findings

• Genetics

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Volume of the Human Hippocampus and Clinical Response Following Electroconvulsive Therapy

66/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry

Key finding: The number of ECT sessions and electrode placement impacts the extent and laterality of hippocampal enlargement, but volume change is not positively associated with clinical outcome. +3 more findings

• Brain Scans
• Treatments

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Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease

47/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in pharmacology

Key finding: Various pathophysiological mechanisms have been proposed by numerous researcher, although, exact mechanism is not yet elucidated. +3 more findings

• Brain Biology

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Relevance of Aβ42/40 Ratio for Detection of Alzheimer Disease Pathology in Clinical Routine: The PLM R Scale

53/100 ✓ Peer-reviewed Biomarkers Frontiers in aging neuroscience

Key finding: Nine hundred and four participants (342 AD and 562 NAD) were studied; 400 in Mtp-1 and 504 in Mtp-2. +4 more findings

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Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa

44/100 ✓ Peer-reviewed Disparities Brain research bulletin

Key finding: Hypertension is the strongest modifiable risk factor for stroke but is also likely associated with co-inheritance of genetic traits among Africans. +1 more finding

• Other Dementias
• Health Equity
• Risk Factors

Full summary, score breakdown and related studies → Original source

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

41/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

Key finding: Neurological diseases, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS) and multiple sclerosis, are often associated with functional gastrointestinal disorders. +1 more finding

• Brain Biology

Full summary, score breakdown and related studies → Original source

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

38/100 ✓ Peer-reviewed Treatments Journal of controlled release : official journal of the Controlled Release Society

Key finding: However, there is also some limitation associated with IN like poor drug permeation through the nasal mucosa and mucociliary clearance.

• Treatments

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Place of death in patients with dementia and the association with comorbidities: a retrospective population-based observational study in Germany

64/100 ✓ Peer-reviewed End-of-life care BMC palliative care

Key finding: The most common place of death in patients with dementia is the retirement or nursing home, followed by hospital and home. +2 more findings

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2

46/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of biological chemistry

Key finding: The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's disease (AD), and the molecular basis of R47H TREM2 loss of function is an emerging area of TREM2 biology. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

MRI Characterizes the Progressive Course of AD and Predicts Conversion to Alzheimer's Dementia 24 Months Before Probable Diagnosis

49/100 ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience

Key finding: The definition of new approaches for the design of proper clinical trials is highly demanded in order to achieve non-confounding results and assess more effective treatment.

• Early Stage
• Diagnosis
• Brain Scans

Full summary, score breakdown and related studies → Original source

Digital technologies as biomarkers, clinical outcomes assessment, and recruitment tools in Alzheimer's disease clinical trials

51/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia (New York, N. Y.)

Key finding: Research indicates that wearable devices and unobtrusive passive sensors that enable the collection of frequent or continuous, objective, and multidimensional data during daily activities may capture subtle changes in cognition and functional capacity long before the onset of dementia.

• Digital Tools
• Clinical Trials

Full summary, score breakdown and related studies → Original source