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Rapid and in situ optical detection of trace lithium in tissues
Irfan Ahmed, Jingwei Yang, Alan Wing Lun Law, Francis A M Manno, Rafay Ahmed, Yanpeng Zhang, Condon Lau. Biomedical optics express, 2018-08-27
Topic: Gut, metabolism and diet
Lithium-based medications are used successfully to treat many mental disorders, including bipolar disorder and Alzheimer's disease. However, the therapeutic mechanisms are not well characterized due to limitations in detecting lithium in organs and cells. This limits the ability to improve lithium-based treatments. To address this need, laser-induced breakdown spectroscopy (LIBS) is developed for the rapid and in situ detection of lithium in biological tissues. Pronounced lithium emissions are observed at 670.7nm from the rat thyroid, salivary, and mammary glands when lithium is administered orally. Calcium, carbon, magnesium, sodium, potassium, and iodine emissions are also observed. The lithium emission intensity is positively correlated with tissue lithium concentration, which is ~1ppm. The limit of detection for lithium is determined to be ~0.1ppm. Thyroid lithium intensity increases while iodine intensity decreases. The reduced intrathyroidal iodine following treatment likely impairs hormone production. Further, the presence of lithium in the salivary and mammary glands makes these glands the likely conduits for lithium to enter the saliva and breast milk, respectively. LIBS is well suited for characterizing the distribution of lithium, and other elements, across the body. This optical method can potentially be adapted for use in vivo and in humans.
Key findings
- Thyroid lithium intensity increases while iodine intensity decreases.
- The reduced intrathyroidal iodine following treatment likely impairs hormone production.
- Further, the presence of lithium in the salivary and mammary glands makes these glands the likely conduits for lithium to enter the saliva and breast milk, respectively.
- LIBS is well suited for characterizing the distribution of lithium, and other elements, across the body.
- This optical method can potentially be adapted for use in vivo and in humans.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biomedical optics express) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30615723) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Ahmed, I., Yang, J., Law, A. W. L., Manno, F. A. M., Ahmed, R., Zhang, Y., et al. (2018). Rapid and in situ optical detection of trace lithium in tissues. Biomedical optics express. https://doi.org/10.1364/boe.9.004459
Vancouver
Ahmed I, Yang J, Law AWL, Manno FAM, Ahmed R, Zhang Y, et al. Rapid and in situ optical detection of trace lithium in tissues. Biomedical optics express. 2018. doi:10.1364/boe.9.004459. PMID: 30615723.
BibTeX
@article{ahmed2018-30615723,
author = {Ahmed, Irfan and Yang, Jingwei and Law, Alan Wing Lun and Manno, Francis A M and Ahmed, Rafay and Zhang, Yanpeng and Lau, Condon},
title = {{Rapid and in situ optical detection of trace lithium in tissues}},
journal = {Biomedical optics express},
year = {2018},
doi = {10.1364/boe.9.004459},
pmid = {30615723},
url = {https://doi.org/10.1364/boe.9.004459}
}
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