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Neurofilaments as biomarkers in neurological disorders
Michael Khalil, Charlotte Elisabeth Teunissen, Markus Otto, Fredrik Piehl, Maria Pia Sormani, Thomas Gattringer, Christian Barro, Ludwig Kappos, Manuel Comabella, Franz Fazekas, Axel Petzold, Kaj Blennow, Henrik Zetterberg, Jens Kühle. Nature Reviews Neurology, 2018-08-31
Topic: Brain proteins, microglia and lab models
This study reviewed the structure, function, analytical aspects, and age-dependent normal ranges of neurofilaments, providing a comprehensive overview of neurofilament light chain as a marker of axonal injury across various neurological disorders. It found that neurofilament protein levels rise upon neuroaxonal damage in both cerebrospinal fluid and blood, indicating injury independent of causal pathways. Additionally, advanced assays now enable reliable measurement of neurofilaments throughout blood sample concentrations.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Khalil, M., Teunissen, C. E., Otto, M., Piehl, F., Sormani, M. P., Gattringer, T., et al. (2018). Neurofilaments as biomarkers in neurological disorders. Nature Reviews Neurology. https://doi.org/10.1038/s41582-018-0058-z
Vancouver
Khalil M, Teunissen CE, Otto M, Piehl F, Sormani MP, Gattringer T, et al. Neurofilaments as biomarkers in neurological disorders. Nature Reviews Neurology. 2018. doi:10.1038/s41582-018-0058-z. PMID: 30171200.
BibTeX
@article{khalil2018-30171200,
author = {Khalil, Michael and Teunissen, Charlotte Elisabeth and Otto, Markus and Piehl, Fredrik and Sormani, Maria Pia and Gattringer, Thomas and Barro, Christian and Kappos, Ludwig and Comabella, Manuel and Fazekas, Franz and Petzold, Axel and Blennow, Kaj and Zetterberg, Henrik and Kühle, Jens},
title = {{Neurofilaments as biomarkers in neurological disorders}},
journal = {Nature Reviews Neurology},
year = {2018},
doi = {10.1038/s41582-018-0058-z},
pmid = {30171200},
url = {https://doi.org/10.1038/s41582-018-0058-z}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 14 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Neurofilament proteins have promise in this context because their levels rise upon neuroaxonal damage not only in the cerebrospinal fluid (CSF) but also in blood, and they indicate neuroaxonal injury independent of causal pathways.
- Third-generation (electrochemiluminescence) and particularly fourth-generation (single-molecule array) assays enable the reliable measurement of neurofilaments throughout the range of concentrations found in blood samples.
Why it matters
A review of neurofilaments as biomarkers in neurological disorders.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
How this study scored 58/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 55 of the 95 points we could judge it on, which is 58 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nature Reviews Neurology) |
| Journal's citation record | 3 / 4 | Nature Reviews Neurology: journal h-index 269 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,980 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 198.0 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 5 / 6 | Cited 31.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 801 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Jens Kühle: h-index 94 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 20 institution(s) in 8 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30171200) |
| Free to read | 2 / 2 | Free to read |
| Points | 55 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 55 of the 95 points we could judge it on is 58 out of 100. |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/s41582-018-0058-z
- PubMed: 30171200
- Original source →
- Free full text: Pure Amsterdam UMC →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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