Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,201–11,225 of 27,380 studies, newest first · page 449 of 1096.
September 2020 25
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2020-09-13
The Brain Chart of Aging: Machine-learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans
55/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: A Brain Chart quantifying brain-aging trajectories was established, enabling the systematic evaluation of individuals' brain-aging patterns relative to this large consortium. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-13
Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP)
66/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Higher vitamin D intake is associated with decreased risk of dementia in a multiethnic cohort. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-12
Contribution of homozygous and compound heterozygous missense mutations in VWA2 to Alzheimer's disease
55/100 ✓ Peer-reviewed Risk genes beyond APOE Neurobiology of aging
Key finding: Overall, we identified 5 patient carriers of homozygous or compound heterozygous missense mutations (5/1165; 0.43 %), 2 in early (2/169; 1.18 %) and 3 in late-onset (3/996; 0.30 %) patients. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-09-11
Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer's Disease
39/100 ✓ Peer-reviewed Drug development Pharmaceuticals (Basel, Switzerland)
Key finding: In this review, four of the most promising strategies, alongside with its most promising agents under investigation or development are highlighted. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-11
Alzheimer's disease biomarkers as predictors of trajectories of depression and apathy in cognitively normal individuals, mild cognitive impairment, and Alzheimer's disease dementia
45/100 ✓ Peer-reviewed Long-term cohort studies International journal of geriatric psychiatry
Key finding: The trajectories of depression and apathy (measured with the Neuropsychiatric Inventory or its questionnaire) were separately modeled using growth mixture models for two cohorts (National Alzheimer's Coordinating Center, NACC, n = 22 760 and Alzheimer's Disease Neuroimaging Initiative, ADNI, n = 1 733). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-11
The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions
47/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration
Key finding: Microglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer's disease (AD), implicating a central role for alterations of the innate immune system in the disease etiology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-10
Assessment of genetic risk for improved clinical-neuropathological correlations
39/100 ✓ Peer-reviewed Genetics Acta neuropathologica communications
Key finding: A dementia with Lewy bodies polygenic score that excluded apolipoprotein E due to its overlap with Alzheimer's disease risk was specifically associated with at least limbic (transitional) Lewy-related pathology and a pathological diagnosis of dementia with Lewy bodies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-10
Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer's Disease
41/100 ✓ Peer-reviewed Inflammation and the immune system Oxidative medicine and cellular longevity
Key finding: The MWMT results showed that SF treatment significantly improved the STZ-induced cognitive deficits in rats. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-10
Association of amyloid-β CSF/PET discordance and tau load 5 years later
60/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: We included 730 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants without dementia (282 cognitively normal, 448 mild cognitive impairment) with baseline [ 18 F]florbetapir PET and CSF Aβ 42 available. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-10
Data-driven discovery of probable Alzheimer's disease and related dementia subphenotypes using electronic health records
58/100 ✓ Peer-reviewed Digital health tools Learning health systems
Key finding: Four subphenotypes were computationally derived that correlated with cardiovascular diseases and mental health illnesses. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-10
Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis
62/100 ✓ Peer-reviewed Disparities PLoS medicine
Key finding: At the beginning of June 2020, there were nearly 7 million reported cases of coronavirus disease 2019 (COVID-19) worldwide and over 400,000 deaths in people with COVID-19.
Full summary, score breakdown and related studies → Original source
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2020-09-09
Lifestyle Risk Factors and Cognitive Outcomes from the Multidomain Dementia Risk Reduction Randomized Controlled Trial, Body Brain Life for Cognitive Decline (BBL-CD)
74/100 ✓ Peer-reviewed Prevention trials Journal of the American Geriatrics Society
Key finding: Outcomes from this trial support the conduct of a larger and longer trial with this participant group. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-09
The Potential of Immersive Virtual Reality for Cognitive Training in Elderly
43/100 ✓ Peer-reviewed Digital health tools Gerontology
Key finding: Aged subjects are found to have sparing of emotional learning and show increased reliance on multisensory integration for learning. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-09
Retracted: Internet-Based Supportive Interventions for Family Caregivers of People With Dementia: Systematic Review and Meta-Analysis
16/100 ⚠ Retracted — do not rely on it Caregiving Journal of medical Internet research
Key finding: Future studies are encouraged to adopt personalized internet-based supportive interventions to improve the health of family caregivers and their care recipients. +2 more findings
Scored 46 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2020-09-09
Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia
59/100 ✓ Peer-reviewed Caregiving Frontiers in psychiatry
Key finding: Increased BPSD was reported in 59.6% of patients as worsening of preexisting symptoms (51.9%) or as new onset (26%), and requested drug modifications in 27.6% of these cases. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-08
Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau
43/100 ✓ Peer-reviewed Treatments Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Key finding: Increasing evidence indicates that AD develops from an intricate web of biochemical and cellular processes that extend far beyond amyloid and tau accumulation.
Full summary, score breakdown and related studies → Original source
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2020-09-08
A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson's disease: preliminary report of benefits associated with the use of a computerized tool
76/100 ✓ Peer-reviewed Prevention trials Aging clinical and experimental research
Key finding: CCT proved effective in PD-MCI patients when compared with traditional PCT. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-08
Alzheimer's Retinopathy: Seeing Disease in the Eyes
46/100 ✓ Peer-reviewed Mild cognitive impairment Frontiers in neuroscience
Key finding: Studies have shown that along with cognitive decline, patients with mild cognitive impairment (MCI) and AD often suffer from visual impairments, abnormal electroretinogram patterns, and circadian rhythm disturbances that can, at least in part, be attributed to retinal damage. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-08
Infection as a Stroke Risk Factor and Determinant of Outcome After Stroke
48/100 ✓ Peer-reviewed Caregiving Stroke
Key finding: Apart from their short-term effects, emerging evidence suggests that poststroke immune changes may also adversely affect long-term cognitive outcomes in patients with stroke, increasing the risk of poststroke neurodegeneration and dementia.
Full summary, score breakdown and related studies → Original source
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2020-09-07
Cerebrovascular pathology in Alzheimer's disease: Hopes and gaps
39/100 ✓ Peer-reviewed Risk factors Psychiatry research. Neuroimaging
Key finding: In particular, we attempt to shed light on the vascular markers and risk factors that are currently ready-to-be-added to the framework: i) lacunes, ii) white matter hyperintensities and iii) microbleeds seen in Flair, T2* weighted imaging and susceptibility images (SWI). +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-07
Deconstructing the Complexities of Advance Care Planning Outcomes: What Do We Know and Where Do We Go? A Scoping Review
67/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society
Key finding: ACP is complex, and trial characteristics were heterogeneous. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-09-07
A pilot feasibility randomized controlled trial on combining mind-body physical exercise, cognitive training, and nurse-led risk factor modification to reduce cognitive decline among older adults with mild cognitive impairment in primary care
74/100 ✓ Peer-reviewed Prevention trials PeerJ
Key finding: In this pilot study, RFM and the multi-domain approach CPR were feasible and had preliminary beneficial effects in older adults with MCI in primary care setting in Hong Kong. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-07
Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing
71/100 ✓ Peer-reviewed Long-term cohort studies Nature communications
Key finding: Cerebrovascular risk factors increase the likelihood of dementia in older people but their impact on cognitive ageing in younger, healthy brains is less clear. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-05
Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet
46/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation
Key finding: Animal work investigating the consequences of maternal high-fat diet (mHFD) revealed in the offspring a maternal immune activation (MIA) phenotype associated with increased inflammatory signals. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-09-04
Global prevalence and burden of HIV-associated neurocognitive disorder: A meta-analysis
75/100 ✓ Peer-reviewed Caregiving Neurology
Key finding: Of 5,588 records identified, we included 123 studies involving 35,513 participants from 32 countries. +3 more findings
Full summary, score breakdown and related studies → Original source
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