Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,951–19,975 of 27,380 studies, newest first · page 799 of 1096.
September 2011 12
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2011-09-01
Vulnerability to depression: from brain neuroplasticity to identification of biomarkers
36/100 ✓ Peer-reviewed Hippocampus size on brain scans The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Our results thus characterize the presence of latent vulnerability traits that underlie the emergence of depression and identify the association of low BDNF with normal corticosterone serum concentrations as a predictive biomarker of vulnerability to depression.
Full summary, score breakdown and related studies → Original source
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2011-09-01
Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration
57/100 ✓ Peer-reviewed Brain tissue and pathology Brain : a journal of neurology
Key finding: Here we present a retrospective analysis of clinical, neuropsychological and neuroimaging (volumetric and voxel-based morphometric) features in a pathologically ascertained cohort of 95 cases of frontotemporal lobar degeneration classified according to contemporary neuropathological criteria. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-01
Neuropsychiatric symptoms in Alzheimer's disease
56/100 ✓ Peer-reviewed Brain tissue and pathology Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Once thought to emerge primarily in people with late-stage disease, these symptoms are currently known to manifest commonly in very early disease and in prodromal phases, such as mild cognitive impairment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-01
Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer's disease neuroimaging initiative
60/100 ✓ Peer-reviewed Tau biomarkers Archives of general psychiatry
Key finding: Biomarkers have become increasingly important in understanding neurodegenerative processes associated with Alzheimer disease. +3 more findings
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2011-09-01
Comprehension of insincere communication in neurodegenerative disease: lies, sarcasm, and theory of mind
48/100 ✓ Peer-reviewed Digital health tools Cortex; a journal devoted to the study of the nervous system and behavior
Key finding: All subjects equally understood sincere remarks, but bvFTD patients displayed impaired comprehension of lies and sarcasm compared with NCs. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-01
Glucose tolerance status and risk of dementia in the community: the Hisayama study
59/100 ✓ Peer-reviewed How common it is Neurology
Key finding: The age- and sex-adjusted incidence of all-cause dementia, Alzheimer disease (AD), and vascular dementia (VaD) were significantly higher in subjects with diabetes than in those with normal glucose tolerance. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-01
Early parental death and remarriage of widowed parents as risk factors for Alzheimer disease: the Cache County study
47/100 ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: Parental death during childhood is associated with higher prevalence of AD, with different critical periods for father's versus mother's death, with strength of these associations attenuated by remarriage of the widowed parent. +4 more findings
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2011-09-01
Geriatric congenital heart disease: burden of disease and predictors of mortality
62/100 ✓ Peer-reviewed Caregiving Journal of the American College of Cardiology
Key finding: The prevalence of geriatric ACHD is substantial, although severe lesions remain uncommon.
Full summary, score breakdown and related studies → Original source
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2011-09-01
The size and burden of mental disorders and other disorders of the brain in Europe 2010
56/100 ✓ Peer-reviewed Caregiving European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Key finding: Prevalence: It is estimated that each year 38.2% of the EU population suffers from a mental disorder. +4 more findings
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2011-09-01
Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging
69/100 ✓ Peer-reviewed Prevention and risk Mayo Clinic proceedings
Key finding: A rapidly growing literature strongly suggests that exercise, specifically aerobic exercise, may attenuate cognitive impairment and reduce dementia risk. +4 more findings
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2011-09-01
Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study
44/100 ✓ Peer-reviewed Genetics Neurology
Key finding: The results of this study suggest that dyslipidemia increases the risk of plaque-type pathology. +2 more findings
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2011-09-01
Neuropathological alterations in Alzheimer disease
57/100 ✓ Peer-reviewed Biomarkers Cold Spring Harbor perspectives in medicine
Key finding: The neuropathological hallmarks of Alzheimer disease (AD) include "positive" lesions such as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial responses, and "negative" lesions such as neuronal and synaptic loss. +3 more findings
Full summary, score breakdown and related studies → Original source
August 2011 13
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2011-08-31
Identification of novel functional inhibitors of acid sphingomyelinase
43/100 ✓ Peer-reviewed Digital health tools PloS one
Key finding: These entities named FIASMAs (Functional Inhibitors of Acid SphingoMyelinAse), therefore, can be potentially used to treat diseases associated with enhanced activity of ASM, such as Alzheimer's disease, major depression, radiation- and chemotherapy-induced apoptosis and endotoxic shock syndrome. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-08-30
Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study)
54/100 ✓ Peer-reviewed Brain scans and imaging The American journal of cardiology
Key finding: In the absence of heart failure, it was hypothesized that left ventricular ejection fraction (LVEF), an indicator of cardiac dysfunction, would be associated with preclinical brain magnetic resonance imaging (MRI) and neuropsychological markers of ischemia and Alzheimer disease in the community. +4 more findings
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2011-08-26
Advance care planning for people with dementia: a review
36/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics
Key finding: The current evidence base for ACP in dementia is limited. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-08-25
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Human molecular genetics
Key finding: Increasing evidence suggests that the accumulation of amyloid beta (Aβ) in synapses and synaptic mitochondria causes synaptic mitochondrial failure and synaptic degeneration in Alzheimer's disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-08-24
Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease
40/100 ✓ Peer-reviewed Risk factors Journal of neuroinflammation
Key finding: The data support that the midbrain may be more sensitive to the neuroinflammatory effects of subchronic air pollution exposure. +3 more findings
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2011-08-23
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
43/100 ✓ Peer-reviewed Brain tissue and pathology Nature Communications
Key finding: Here we produce multiple induced pluripotent stem cell lines from an SNCA triplication patient and an unaffected first-degree relative. +4 more findings
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2011-08-22
Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans
40/100 ✓ Peer-reviewed Brain scans and imaging Proceedings of the National Academy of Sciences of the United States of America
Key finding: Antidepressant-treated participants had significantly less amyloid load as quantified by positron emission tomography (PET) imaging with Pittsburgh Compound B (PIB). +1 more finding
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2011-08-22
Care at the end of life for people with dementia living in a care home: a qualitative study of staff experience and attitudes
36/100 ✓ Peer-reviewed End-of-life care International journal of geriatric psychiatry
Key finding: The staff require education and support about discussing and implementing plans around care at the end of life in dementia and about cultural issues around death to improve practice.
Full summary, score breakdown and related studies → Original source
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2011-08-21
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
62/100 ✓ Peer-reviewed Lewy body dementia Nature
Key finding: Functional analysis showed that mutations in UBQLN2 lead to an impairment of protein degradation. +1 more finding
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2011-08-20
Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment
45/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging
Key finding: AD patients displayed lower FC within the default-mode network (DMN) in the precuneus and posterior cingulate cortex compared with controls, independent of cortical atrophy. +3 more findings
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2011-08-19
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
36/100 ✓ Peer-reviewed Clinical trials Nature reviews. Drug discovery
Key finding: The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide in the brain is a central event in Alzheimer's disease pathology, has dominated research for the past twenty years. +2 more findings
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2011-08-17
Six-month walking program changes cognitive and ADL performance in patients with Alzheimer
64/100 ✓ Peer-reviewed Health systems and care delivery American journal of Alzheimer's disease and other dementias
Key finding: The WG showed significant improvement in the 6WT (20%) and ADLs (23%), while the CG decreased in MMSE (-47%), the WG had a slower decline (-13%). +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-08-17
Data mining methods in the prediction of Dementia: A real-data comparison of the accuracy, sensitivity and specificity of linear discriminant analysis, logistic regression, neural networks, support vector machines, classification trees and random forests
47/100 ✓ Peer-reviewed Digital health tools BMC research notes
Key finding: These methods may be used to improve accuracy, sensitivity and specificity of Dementia predictions from neuropsychological testing. +2 more findings
Full summary, score breakdown and related studies → Original source
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