Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 7,451–7,475 of 27,380 studies, newest first · page 299 of 1096.
August 2023 14
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2023-08-07
A blood biomarker test for brain amyloid impacts the clinical evaluation of cognitive impairment
70/100 ✓ Peer-reviewed Biomarkers Annals of clinical and translational neurology
Key finding: A 95% (347/366) concordance rate was noted between clinicians' patient selection and the test's intended use criteria. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-04
The gut microbiota-brain axis in neurological disorder
43/100 ✓ Peer-reviewed Disease mechanisms Frontiers in neuroscience
Key finding: Increasing preclinical and clinical studies/evidence indicate that gut microbes are a possible susceptibility factor for the progression of neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS) and autism spectrum disorder (ASD).
Full summary, score breakdown and related studies → Original source
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2023-08-03
Prevalence of treated patients with Alzheimer's disease: current trends and COVID-19 impact
45/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy
Key finding: Crude AD prevalence (2015-2020) was estimated at 760.5 per 100,000 inhabitants, and age-standardized prevalence (2020) was 664.6 (male 595.7, female 711.0). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-03
Current and future therapeutic strategies for Alzheimer's disease: an overview of drug development bottlenecks
43/100 ✓ Peer-reviewed Treatments Frontiers in aging neuroscience
Key finding: It causes cognitive dysfunction, such as aphasia and agnosia, and mental symptoms, such as behavioral abnormalities; all of which place a significant psychological and economic burden on the patients' families. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-08-03
Advanced brain imaging for the diagnosis of Alzheimer disease
42/100 ✓ Peer-reviewed Biomarkers Current opinion in neurology
Key finding: The purpose is to review the latest advances of brain imaging for the diagnosis of Alzheimer disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-03
Plasma neurofilament light chain in relation to 10-year change in cognition and neuroimaging markers: a population-based study
54/100 ✓ Peer-reviewed Biomarkers GeroScience
Key finding: Higher plasma NfL was associated with worse cognitive performance at baseline (g-factor: β = - 0.12 (- 0.15; - 0.09), p < 0.001), and accelerated cognitive decline during follow-up on the Stroop color naming task (β = 0.04 (0.02; 0.06), p < 0.001), with a smaller trend for decline in global cognition (g-factor β = - 0.02 (- 0.04; 0.00), p = 0.044). +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-02
Neurovascular glial unit: A target of phytotherapy for cognitive impairments
50/100 ✓ Peer-reviewed Inflammation and the immune system Phytomedicine : international journal of phytotherapy and phytopharmacology
Key finding: Herbal medicines demonstrate great potential to prevent cognitive impairment.
Full summary, score breakdown and related studies → Original source
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2023-08-02
Factors associated with medication adherence in older adults: The atherosclerosis risk in communities study
53/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society
Key finding: We examined factors associated with self-reported medication nonadherence in well-characterized community-based cohort of older adults. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-02
Association Between Socioeconomic Factors, Race, and Use of a Specialty Memory Clinic
60/100 ✓ Peer-reviewed Risk factors Neurology
Key finding: 4,824 patients seen at the memory clinic between 2008-2018 were included in this study (mean age 72.7 [standard deviation 11.0] years, 2,712 [56%] female, 543 [11%] Black). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-02
Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis
50/100 ✓ Peer-reviewed TREM2 and immune genetics Hepatology (Baltimore, Md.)
Key finding: Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease for which pharmacological treatment options are currently unavailable. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-01
Objectively Measured Visual Impairment and Dementia Prevalence in Older Adults in the US
53/100 ✓ Peer-reviewed Cognitive tests and assessment JAMA ophthalmology
Key finding: In this survey study, all types of objectively measured VI were associated with a higher dementia prevalence. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-08-01
Considering Questions Before Methods in Dementia Research With Competing Events and Causal Goals
68/100 ✓ Peer-reviewed Long-term cohort studies American journal of epidemiology
Key finding: Researchers often interpret death as a potential source of bias, although bias cannot be defined or assessed if the causal question is not explicitly specified. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-01
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease
51/100 ✓ Peer-reviewed TREM2 and immune genetics Cell stem cell
Key finding: Much controversy exists around the complex and multifaceted pathogenesis of this prevalent disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-01
Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial
74/100 ✓ Peer-reviewed Treatments JAMA
Key finding: Among 1736 randomized participants (mean age, 73.0 years; 996 [57.4%] women; 1182 [68.1%] with low/medium tau pathology and 552 [31.8%] with high tau pathology), 1320 (76%) completed the trial. +2 more findings
Full summary, score breakdown and related studies → Original source
July 2023 11
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2023-07-31
Healthcare Utilization and Advance Care Planning among Older Adults Across Cognitive Levels
64/100 ✓ Peer-reviewed End-of-life care Journal of applied gerontology : the official journal of the Southern Gerontological Society
Key finding: The results showed that having an ACP was associated with longer stays in hospitals, nursing homes, and home healthcare in all participants.
Full summary, score breakdown and related studies → Original source
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2023-07-31
‘Good, honest food’: older adults' and healthcare professionals' perspectives of dietary influences and food preferences in older age in Ireland
41/100 ✓ Peer-reviewed Risk factors Journal of Human Nutrition and Dietetics
Key finding: A total of 47 adults aged 55+ years were recruited (50% male; 49% aged 60-69 years; 28% aged above 70 years), and 26 HCPs were involved, comprising dietitians (n = 8); geriatricians (n = 6); clinical therapists (n = 4); and nurses, pharmacists, catering managers and meal delivery service coordinators (n = 2 each). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-30
Plasma-derived biomarkers of Alzheimer's disease and neuropsychiatric symptoms: A community-based study
68/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: P-tau181 (odds ratio [OR] 2.06, 95% confidence interval [CI] 1.41-3.00, p < 0.001), p-tau217 (OR 1.70, 95% CI 1.10-2.61, p = 0.016), and t-tau (OR 1.44, 95% CI 1.08-1.92, p = 0.012) were associated with appetite change. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-29
Blood-Brain Barrier Dysfunction and Aβ42/40 Ratio Dose-Dependent Modulation with the ApoE Genotype within the ATN Framework
50/100 ✓ Peer-reviewed Biomarkers International journal of molecular sciences
Key finding: Our data showed that there was no difference in BBB dysfunction across different ATN subtypes, and that BBB damage was not correlated with cognitive impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-07-29
Alzheimer's polygenic risk scores, APOE, Alzheimer's disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years
67/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy
Key finding: The use of PRSs may be beneficial for increased precision in risk estimates among APOE4 carriers. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-29
Optimizing detection of Alzheimer's disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO
58/100 ✓ Peer-reviewed Tau biomarkers Molecular neurodegeneration
Key finding: Disease-modifying drug use necessitates better Alzheimer disease (AD) detection. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-29
The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders
35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of chemical neuroanatomy
Key finding: Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are nearly ubiquitously expressed. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-28
TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease
46/100 ✓ Peer-reviewed TREM2 and immune genetics Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Key finding: However, there is no specific treatment to mechanistically inhibit the progression of Alzheimer's disease, and most drugs only provide symptom relief and do not fundamentally reverse AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-27
Association of Choroid Plexus Volume With Serum Biomarkers, Clinical Features, and Disease Severity in Patients With Frontotemporal Lobar Degeneration Spectrum
65/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: Choroid plexus (ChP) is emerging as a key brain structure in the pathophysiology of neurodegenerative disorders. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-07-26
Antiamyloid Monoclonal Antibody Therapy for Alzheimer Disease: Emerging Issues in Neurology
43/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Given that these new antiamyloid monoclonal antibodies (mAbs) are associated with nontrivial risks and burdens of treatment that are radically different from current mainstays of AD management, effectively and equitably translating their use to real-world clinical care will require systematic and practice-specific modifications to existing workflows and infrastructure.
Full summary, score breakdown and related studies → Original source
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2023-07-26
Improving the Bioavailability and Efficacy of Coenzyme Q10 on Alzheimer's Disease Through the Arginine Based Proniosomes
37/100 ✓ Peer-reviewed Tau biomarkers Journal of pharmaceutical sciences
Key finding: CoQ10 plays a role in membrane stability, energy conversion, and ATP production. +3 more findings
Full summary, score breakdown and related studies → Original source
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