Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 14,326–14,350 of 27,380 studies, newest first · page 574 of 1096.
January 2018 25
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2018-01-15
New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation
41/100 ✓ Peer-reviewed Clinical trials British journal of pharmacology
Key finding: Clinically meaningful effects of melatonin treatment have been demonstrated in placebo-controlled trials in humans, particularly in disorders associated with diminished or misaligned melatonin rhythms, for example, circadian rhythm-related sleep disorders, jet lag and shift work, insomnia in children with neurodevelopmental disorders, poor (non-restorative) sleep quality, non-dipping nocturnal blood pressure (nocturnal hypertension) and Alzheimer's disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-01-15
Causal associations between risk factors and common diseases inferred from GWAS summary data
45/100 ✓ Peer-reviewed Genetics Nature communications
Key finding: Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-01-15
Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response
53/100 ✓ Peer-reviewed Prevention and risk Nature neuroscience
Key finding: A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia, but it remains unclear how dietary salt harms the brain. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-01-14
Person-specific contribution of neuropathologies to cognitive loss in old age
70/100 ✓ Peer-reviewed How common it is Annals of neurology
Key finding: Neuropathology was ubiquitous, with 94% of participants having 1+, 78% having 2+, 58% having 3+, and 35% having 4+.
Full summary, score breakdown and related studies → Original source
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2018-01-13
Effect of a robotic seal on the motor activity and sleep patterns of older people with dementia, as measured by wearable technology: A cluster-randomised controlled trial
64/100 ✓ Peer-reviewed Digital health tools Maturitas
Key finding: PARO may have some effect on motor activity of older people with dementia in long-term care, but not on sleep patterns. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-01-12
Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults
62/100 ✓ Peer-reviewed Brain scans and imaging The American journal of psychiatry
Key finding: Higher amyloid beta burden was associated with increasing anxious-depressive symptoms over time in cognitively normal older individuals. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-12
Application of Metabolomics in Alzheimer's Disease
41/100 ✓ Peer-reviewed Genetics Frontiers in neurology
Key finding: Advancements in the field of metabolomics have demonstrated the complexity of dynamic changes associated with AD progression underscoring challenges with the development of efficacious therapeutic interventions.
Full summary, score breakdown and related studies → Original source
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2018-01-12
Noncoding RNAs in Alzheimer's disease
46/100 ✓ Peer-reviewed Caregiving Wiley interdisciplinary reviews. RNA
Key finding: However, the full spectrum of molecular factors that contribute to AD pathogenesis is not known. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-11
Differential Effects of Alzheimer's Disease Aβ40 and 42 on Endocytosis and Intraneuronal Trafficking
39/100 ✓ Peer-reviewed Biomarkers Neuroscience
Key finding: We have shown substantial down-regulation of KEGG endocytotic pathway genes in AD patient brain regions that accumulate Aβ compared to those in non-demented individuals. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-11
Brain Photobiomodulation Therapy: a Narrative Review
38/100 ✓ Peer-reviewed Vascular contributions Molecular neurobiology
Key finding: Moreover, light absorption by ion channels results in release of Ca 2+ and leads to activation of transcription factors and gene expression.
Full summary, score breakdown and related studies → Original source
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2018-01-11
The role of education in the association between race/ethnicity/nativity, cognitive impairment, and dementia among older adults in the United States
50/100 ✓ Peer-reviewed Disparities Demographic research
Key finding: Among women, foreign-born Hispanics have higher odds of CIND and dementia than Whites. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-11
CSF neurogranin or tau distinguish typical and atypical Alzheimer disease
47/100 ✓ Peer-reviewed Biomarkers Annals of clinical and translational neurology
Key finding: These results show significant differences in neurogranin and total-tau between typical and atypical patients, which may relate to factors other than disease topography. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-10
Reprogramming neurodegeneration in the big data era
39/100 ✓ Peer-reviewed Genetics Current opinion in neurobiology
Key finding: Recent genome-wide association studies (GWAS) have identified numerous genetic risk variants for late-onset Alzheimer's disease (AD) and Parkinson's disease (PD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-10
Association Between Sensory Impairment and Dementia in Older Adults: Evidence from China
60/100 ✓ Peer-reviewed Risk factors Journal of the American Geriatrics Society
Key finding: Sensory impairments are associated with greater risk of dementia in Chinese older adults. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-10
Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex
41/100 ✓ Peer-reviewed Disease mechanisms Scientific reports
Key finding: Here by using whole-cell recordings in acute mouse brain slices, we found that 50 nM Aβ induces hyperexcitability of excitatory pyramidal cells in the cingulate cortex, one of the most vulnerable areas in AD, via depressing inhibitory synaptic transmission. +1 more finding
Full summary, score breakdown and related studies → Original source
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2018-01-10
The rs75932628 and rs2234253 polymorphisms of the TREM2 gene were associated with susceptibility to frontotemporal lobar degeneration in Caucasian populations
51/100 ✓ Peer-reviewed TREM2 and immune genetics Annals of human genetics
Key finding: Polymorphisms of the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been reported to be potentially associated with the risks of developing frontotemporal lobar degeneration (FTLD), with inconsistent conclusions. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-10
Cerebrospinal fluid Alzheimer biomarkers can be useful for discriminating dementia with Lewy bodies from Alzheimer's disease at the prodromal stage
50/100 ✓ Peer-reviewed Tau biomarkers Journal of neurology, neurosurgery, and psychiatry
Key finding: Differential diagnosis between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) is not straightforward, especially in the early stages of disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-10
Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism
56/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of experimental medicine
Key finding: The R47H variant of the microglial receptor TREM2 triples AD risk in genome-wide association studies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-10
Use of multimodality imaging and artificial intelligence for diagnosis and prognosis of early stages of Alzheimer's disease
51/100 ✓ Peer-reviewed Digital health tools Translational research : the journal of laboratory and clinical medicine
Key finding: Making a diagnosis of AD and offering a prognosis (likelihood of converting to AD) at these early stages are challenging tasks but possible with the help of multimodality imaging, such as magnetic resonance imaging (MRI), fluorodeoxyglucose (FDG)-positron emission topography (PET), amyloid-PET, and recently introduced tau-PET, which provides different but complementary information. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-10
Comparing 18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease
56/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: CSF tau and 18 F-AV-1451 have equal performance in early clinical stages of AD, but 18 F-AV-1451 is superior in the dementia stage, and exhibits close to perfect diagnostic performance for mild to moderate AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-10
Diet, nutrition and the ageing brain: current evidence and new directions
43/100 ✓ Peer-reviewed Prevention and risk The Proceedings of the Nutrition Society
Key finding: There is some evidence linking certain dietary patterns, particularly the Mediterranean diet, with a reduced risk of dementia and depression. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-10
Falls in Cognitively Impaired Older Adults: Implications for Risk Assessment And Prevention
49/100 ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society
Key finding: Falls remain common in older people, with higher prevalence and morbidity in those who are cognitively impaired.
Full summary, score breakdown and related studies → Original source
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2018-01-09
Therapeutic potential of spinal GLP-1 receptor signaling
39/100 ✓ Peer-reviewed Drug development Peptides
Key finding: GLP-1R is expressed in multiple organs and numerous experimental studies have demonstrated that GLP-1 signaling pathway exhibits pro-survival functions in various disorders. +2 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-09
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
71/100 ✓ Peer-reviewed Inflammation and the immune system PLoS medicine
Key finding: We found up to 270-fold genetic enrichment between FTD and RA, up to 160-fold genetic enrichment between FTD and UC, up to 180-fold genetic enrichment between FTD and T1D, and up to 175-fold genetic enrichment between FTD and CeD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2018-01-09
Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review
51/100 ✓ Peer-reviewed Disease mechanisms Alzheimer's research & therapy
Key finding: Dominance of 4R over three-repeat (exon 10-) tau isoforms contrasts with earlier reports of R406W patients and was not sufficiently explained by the presence of H1/H2 haplotypes in two of the autopsied patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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