Newest studies

Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study

70/100 ✓ Peer-reviewed Getting a diagnosis JAMA psychiatry

Key finding: Those reporting depressive symptoms in 1985 (mean follow-up, 27 years) did not have significantly increased risk for dementia (hazard ratio [HR], 1.21; 95% CI, 0.95-1.54) in Cox regression adjusted for sociodemographic covariates, health behaviors, and chronic conditions. +4 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

The microcirculation: a key player in obesity-associated cardiovascular disease

45/100 ✓ Peer-reviewed Prevention and risk Cardiovascular research

Key finding: It is increasingly recognized that obesity is a risk factor for microvascular disease, involving both structural and functional changes in the microvasculature. +4 more findings

• Risk Factors

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Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study

66/100 ✓ Peer-reviewed Prevention and risk JAMA Psychiatry

Key finding: Depressive symptoms at a 2003 assessment (closer to eventual dementia diagnosis) were linked to 72% higher dementia risk (HR 1.72) +3 more findings

• Diagnosis

Full summary, score breakdown and related studies → Original source

Baseline Performance Predicts tDCS-Mediated Improvements in Language Symptoms in Primary Progressive Aphasia

42/100 ✓ Peer-reviewed Digital health tools Frontiers in human neuroscience

Key finding: Prior studies suggest that transcranial direct current stimulation (tDCS) directed toward language areas of the brain may help to ameliorate symptoms of PPA. +1 more finding

• Other Dementias

Full summary, score breakdown and related studies → Original source

Complex Clinical Intersection: Palliative Care in Patients with Dementia

39/100 ✓ Peer-reviewed End-of-life care The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Because of the rapidly growing older population and increases in longevity, rates of dementia have been rising. +4 more findings

• End-of-Life Care

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Assessing the binding of cholinesterase inhibitors by docking and molecular dynamics studies

39/100 ✓ Peer-reviewed Treatments Journal of molecular graphics & modelling

Key finding: Dockings by the softwares Autodock-Vina, PatchDock and Plant reproduced the docked conformations of the inhibitor-enzyme complexes within 2Å of RMSD of the X-ray structure. +4 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Rare causes of early-onset dystonia-parkinsonism with cognitive impairment: a de novo PSEN-1 mutation

39/100 ✓ Peer-reviewed Risk genes beyond APOE Neurogenetics

Key finding: Whole exome sequencing revealed a novel PSEN1 mutation and segregation within the family demonstrated the mutation arose de novo.

• Genetics
• Other Dementias

Full summary, score breakdown and related studies → Original source

Glial contributions to neurodegeneration in tauopathies

54/100 ✓ Peer-reviewed Inflammation and the immune system Molecular neurodegeneration

Key finding: Activated microglia, astrocytes and elevated levels of proinflammatory molecules are also pathological hallmarks that are found in brain regions affected by tau pathology. +3 more findings

• Brain Biology

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A prospective 20-year longitudinal follow-up of dementia in persons with Down syndrome

53/100 ✓ Peer-reviewed Brain tissue and pathology Journal of intellectual disability research : JIDR

Key finding: Goal To examine dementia characteristics, age at onset and associated co-morbidities in persons with Down syndrome. +3 more findings

• Down Syndrome

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Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

55/100 ✓ Peer-reviewed Lewy body dementia Nature communications

Key finding: Physiological TDP-43 oligomerization is mediated by its N-terminal domain, which can adopt dynamic, solenoid-like structures, as revealed by a 2.1 Å crystal structure in combination with nuclear magnetic resonance spectroscopy and electron microscopy. +2 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

MicroRNAs as Important Regulators of Exercise Adaptation

39/100 ✓ Peer-reviewed Prevention trials Progress in cardiovascular diseases

Key finding: A significant body of evidence supports the protective role of exercise training (ET) in cardiovascular diseases, skeletal muscle dystrophies, several types of cancer, Alzheimer disease or even in the recovery of spinal cord injury.

• Lifestyle

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Slowing gait and risk for cognitive impairment: The hippocampus as a shared neural substrate

59/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology

Key finding: The association between gait slowing and cognitive impairment is supported by a shared neural substrate that includes a smaller right hippocampus.

• Brain Scans

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Risk factors for mortality in elderly patients with hip fractures: a meta-analysis of 18 studies

83/100 ✓ Peer-reviewed Clinical safety Aging clinical and experimental research

Key finding: The current study investigated several factors that might increase the risk of mortality in elderly patients with hip fracture. +2 more findings

• Risk Factors

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Prevalence and Determinants of Poor Food Intake of Residents Living in Long-Term Care

46/100 ✓ Peer-reviewed Clinical safety Journal of the American Medical Directors Association

Key finding: This is the first study to consider resident, unit, staff, and home variables that are associated with food intake. +4 more findings

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The Association between the Mediterranean Dietary Pattern and Cognitive Health: A Systematic Review

63/100 ✓ Peer-reviewed Prevention and risk Nutrients

Key finding: Cross-sectional studies and cohort studies in the non-Mediterranean region showed mixed results. +1 more finding

• Lifestyle
• Risk Factors

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Odor identification as a biomarker of preclinical AD in older adults at risk

62/100 ✓ Peer-reviewed Genetics Neurology

Key finding: These findings from healthy high-risk older individuals suggest that OI reflects degree of preclinical AD pathology, while its relationships with age and cognition result from the association of these latter variables with such pathology. +2 more findings

• Biomarkers
• Early Stage
• Genetics

Full summary, score breakdown and related studies → Original source

Corpus callosum macro and microstructure in late-life depression

50/100 ✓ Peer-reviewed Risk factors Journal of affective disorders

Key finding: Callosal AFD was lower in patients compared to controls. +4 more findings

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A facilitated approach to family case conferencing for people with advanced dementia living in nursing homes: perceptions of palliative care planning coordinators and other health professionals in the IDEAL study

66/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics

Key finding: The facilitated approach explored in this study addressed known barriers to case conferencing.

• Clinical Trials
• End-of-Life Care
• Caregiving

Full summary, score breakdown and related studies → Original source

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice

46/100 ✓ Peer-reviewed TREM2 and immune genetics Scientific reports

Key finding: HFD significantly increased amyloid plaques and worsened cognitive performance compared to mice on normal diet (ND). +3 more findings

• Brain Biology
• Genetics
• Lifestyle

Full summary, score breakdown and related studies → Original source

Digitally translated Self-Administered Gerocognitive Examination (eSAGE): relationship with its validated paper version, neuropsychological evaluations, and clinical assessments

58/100 ✓ Peer-reviewed Digital health tools Alzheimer's research & therapy

Key finding: It shows no scale bias compared to SAGE.

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Music-based interventions in neurological rehabilitation

52/100 ✓ Peer-reviewed Digital health tools The Lancet. Neurology

Key finding: During the past ten years, an increasing number of controlled studies have assessed the potential rehabilitative effects of music-based interventions, such as music listening, singing, or playing an instrument, in several neurological diseases. +4 more findings

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Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis

38/100 ✓ Peer-reviewed Disease mechanisms Cellular and molecular life sciences : CMLS

Key finding: In particular, the gastrointestinal tract communicates with the central nervous system through the gut-brain axis to support neuronal development and maintenance while gut dysbiosis manifests in neurological disease. +4 more findings

• Brain Biology

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A qualitative study exploring the difficulties influencing decision making at the end of life for people with dementia

41/100 ✓ Peer-reviewed End-of-life care Health expectations : an international journal of public participation in health care and health policy

Key finding: This study suggests that decision making at the end of life for people with dementia has the potential to be improved. +1 more finding

• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study

73/100 ✓ Peer-reviewed Getting a diagnosis BMJ (Clinical research ed.)

Key finding: This study found no evidence of a neuroprotective effect of physical activity. +3 more findings

• Risk Factors
• Diagnosis
• Lifestyle

Full summary, score breakdown and related studies → Original source

Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study

66/100 ✓ Peer-reviewed Prevention and risk BMJ

Key finding: Among 10,308 people followed 27 years on average, meeting physical activity guidelines was not linked to lower dementia risk (HR 1.00) +3 more findings

• Lifestyle

Full summary, score breakdown and related studies → Original source