Newest studies

How bereaved adult-children of parents with dementia use end-of-life caregiving experiences to inform their personal advance care planning

42/100 ✓ Peer-reviewed End-of-life care The Journals of Gerontology Series B

Key finding: Participants actively contemplated ACP following their parents' death, referring to their end-of-life caregiving experiences as guideposts for issues to anticipate and opportunities to enhance receipt of healthcare during serious illness or incapacitation. +4 more findings

• End-of-Life Care
• Caregiving

Full summary, score breakdown and related studies → Original source

Integrated amyloid, neurodegeneration, and vascular biomarkers estimate the risk of dementia progression in mild cognitive impairment

51/100 ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer s Disease

Key finding: The prominent prognostic role of carotid plaques in Aβ-negative MCI underscores the vascular contributions to non-amyloid cognitive decline and highlights the importance of evaluating both AD-related and vascular mechanisms in prodromal dementia.

• Early Stage
• Biomarkers
• Brain Scans

Full summary, score breakdown and related studies → Original source

A plasma protein signature for cerebral amyloid angiopathy

51/100 ✓ Peer-reviewed Treatments Acta Neuropathologica

Key finding: Notably, in the new era of disease-modifying treatments for AD, CAA is a significant risk factor for amyloid-related imaging abnormalities (ARIA), an adverse event associated with anti-amyloid treatments. +1 more finding

• Treatments
• Side Effects

Full summary, score breakdown and related studies → Original source

Young adult urbanicity, late midlife neighborhood disadvantage, and cognitive functioning in community-dwelling older men

35/100 ✓ Peer-reviewed Risk factors The Journals of Gerontology Series B

Key finding: Compared to those in rural areas, participants who resided in urban areas during young adulthood had lower late midlife ADI (β = -0.85, p < .05), and better executive function (β = 0.19), processing speed (β = 0.24), and verbal fluency (β = 0.30) (ps < .05) in older adulthood. +3 more findings

• Health Equity

Full summary, score breakdown and related studies → Original source

Smoking Cessation, Weight Change, and Risk of Dementia: A Prospective Cohort Study

65/100 ✓ Peer-reviewed Prevention and risk Neurology

Key finding: Smoking cessation was associated with a sustained lower dementia risk and slower cognitive decline, comparable to never smokers and those without short-term risk increase. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Beyond Cardiology's Pillars: A Network Meta-Analysis Comparing the Recombinant Zoster Vaccine (Shingrix/RZV) with SGLT2 Inhibitors and GLP-1 Receptor Agonists for Prevention of Major Adverse Cardiovascular Events and Dementia in Adults Aged ≥50 Years

16/100 ⚠ Preprint — not yet peer-reviewed Drug development Research Square

Key finding: Eligible studies reported MACE or dementia outcomes in adults ≥ 50 years for at least one of three intervention classes (RZV, SGLT2i, GLP-1 RA) versus placebo or active comparator, with follow-up ≥ 6 months. +4 more findings

• Prevention
• Risk Factors

Scored 52 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Re: Clarifying comparative claims in digital cognitive assessment: Assessing concurrent validity in a shared cohort

54/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's research & therapy

Key finding: The assertion that our findings rely on "nonequivalent cohorts" or "outdated regulatory data" is factually incorrect; performance metrics were calculated de novo using the harmonized study dataset. +2 more findings

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Prediabetes as a critical stage for risk of dementia and stroke: evidence from the UK Biobank and Mendelian randomization

48/100 ✓ Peer-reviewed Long-term cohort studies European Journal of Preventive Cardiology

Key finding: During a median 13.7 years of follow-up, prediabetes (n=52,693) was associated with higher risks of vascular dementia (hazard ratio (HR):1.36; 95% confidence interval (CI): 1.14-1.61), stroke (HR:1.09; 95% CI: 1.01-1.16), ischemic stroke (HR:1.10; 95% CI: 1.02-1.19), and intracerebral hemorrhage (HR:1.19; 95% CI: 1.01-1.39) compared with normoglycemia, after adjustment for major confounding factors and across extensive sensitivity analyses. +4 more findings

• Brain Scans
• Risk Factors

Full summary, score breakdown and related studies → Original source

Sex differences in modifiable risk factors of dementia and their associations with cognition

54/100 ✓ Peer-reviewed Risk factors Biology of Sex Differences

Key finding: This study included 17,182 participants with a mean age of 69.2 ± 10.6 years, 59.2% of which were women. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Global, regional and country-specific burden of dementia associated with depression across the life-course

34/100 ✓ Peer-reviewed Risk factors Archives of Gerontology and Geriatrics

Key finding: MDD prevalence was consistently higher among women than men across all regions and age groups, ranging from 4.42%-5.11% in women versus 2.87%-3.41% in men. +4 more findings

Full summary, score breakdown and related studies → Original source

Brain endothelial Gαq/11 signalling in cerebrovascular function and cognition of aged mice

45/100 ✓ Peer-reviewed Vascular contributions EBioMedicine

Key finding: The brain endothelial Gαq/11 signalling pathway preserves normal vascular reactivity, and its loss resembles mild endothelial dysfunction in the brain. +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Association of neighborhood deprivation with Alzheimer's Disease pathology, brain structure, and cognition by race and ethnicity, sex, and APOE ε4 status

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv : the preprint server for health sciences

Key finding: We conducted exploratory, linear models testing ADI interactions with sex, race and ethnicity, and APOE ε4, adjusting for age and education. +4 more findings

• Health Equity
• Genetics

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

The AHEPA EEG benchmark: setting the standard for machine learning in dementia diagnosis, a scoping review

36/100 ✓ Peer-reviewed Digital health tools Cognitive Neurodynamics

Key finding: The open-access AHEPA dataset has become the most commonly used benchmark for Alzheimer's disease (AD) and Frontotemporal dementia (FTD) classification, yet reported results vary widely due to methodological inconsistencies. +3 more findings

• Digital Tools

Full summary, score breakdown and related studies → Original source

Explainable machine learning for predicting longitudinal dementia status: Establishing a leakage-free benchmark

50/100 ✓ Peer-reviewed Digital health tools PLOS Digital Health

Key finding: XAI analyses revealed that (i) Mini-Mental State Examination and atlas-scaling-factor dynamics dominated SVC decisions, while (ii) education, age, and estimated total intracranial volume were critical for LGBM predictions. +1 more finding

• Digital Tools

Full summary, score breakdown and related studies → Original source

Investigating dementia patterns by machine learning and graph-based marker analysis for multiclass dementia diagnosis

35/100 ✓ Peer-reviewed Getting a diagnosis Discover Computing

Key finding: Dementia is a debilitating disease that leads to a gradual loss of memory and other cognitive abilities and tends to develop in people over 60 years of age. +1 more finding

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Methodological Considerations for Quantile Aggregation in Alzheimer Disease Trials

58/100 ✓ Peer-reviewed Treatments JAMA Neurology

Key finding: This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.

• Clinical Trials

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Spatial heterogeneity and influencing factors of cognitive impairment among elderly hypertensive patients: evidence from rural communities in China

44/100 ✓ Peer-reviewed Risk factors BMC Geriatrics

Key finding: Central-northern rural communities exhibited the most pronounced high-high spatial clustering of cognitive impairment (Global Moran's I = 0.17, p < 0.001). +4 more findings

• Health Equity
• Lifestyle

Full summary, score breakdown and related studies → Original source

Blood biomarkers for Alzheimer disease across ethnoracial groups and healthcare settings: a systematic review and meta-analysis

16/100 ⚠ Preprint — not yet peer-reviewed Tau biomarkers medRxiv

Key finding: We systematically reviewed 168 publications comprising 139 independent cohorts from Asia, Europe, North America, South America, Africa and Oceania. +3 more findings

• Biomarkers

Scored 37 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Prenatal Pesticide Exposure and Early Alzheimer Disease-Related Biomarker and Cognitive Changes in Midlife

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: In this prospective birth cohort study, prenatal exposure to a persistent environmental toxicant was associated with lower plasma Aβ42/40 ratio and worse cognitive performance in midlife, consistent with DDE accelerating the preclinical trajectory of AD-related biological changes decades before symptom onset. +4 more findings

• Biomarkers
• Genetics

Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Peripheral biomarkers of neuroinflammation in Alzheimer's disease and vascular dementia

48/100 ✓ Peer-reviewed Inflammation and the immune system Biochemical pharmacology

Key finding: Evidence suggests that neuroinflammation is not merely a downstream response to tissue injury, but actively participates in the bidirectional pathological loop linking Aβ aggregation, tau hyperphosphorylation, and vascular dysfunction.

• Brain Biology
• Other Dementias
• Biomarkers

Full summary, score breakdown and related studies → Original source

High-definition Transcranial Direct Current Stimulation Improves Cognitive Function in Patients with Cerebral Small Vessel Disease: An Open-label Pilot Study Informed by Cross-sectional Analysis

39/100 ✓ Peer-reviewed Vascular contributions Current Neuropharmacology

Key finding: In part 1 of the study, the patients with CSVD showed significant differences in Montreal Cognitive Assessment (MoCA), Auditory Verbal Learning Test (AVLT)-study, AVLT-immediate, AVLT-delay, AVLT-recognition, Trail Making Test (TMT)-A, TMT-B, and Verbal Fluency Test -fruits/vegetables compared with HCs. +4 more findings

• Diagnosis
• Other Dementias

Full summary, score breakdown and related studies → Original source

Transport pathways across the blood-brain barrier for waste clearance and drug delivery

38/100 ✓ Peer-reviewed Treatments Fluids and Barriers of the CNS

Key finding: Additionally, this review discusses two other important proteins, which have been less frequently addressed in research regarding transport mechanisms: P-glycoprotein (P-gp) as another transporter at the BBB and proprotein convertase subtilisin/kexin type 9 (PCSK9), a well-known regulator of cholesterol homeostasis which promotes the degradation of the low-density lipoprotein receptor (LDLR) and LRP1. +4 more findings

• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source

Real-World Performance of Urine β-amyloid Test Kits in Multiple Hospital Clinics and Neighborhood Communities of China

16/100 ⚠ Preprint — not yet peer-reviewed Treatments medRxiv

Key finding: Our findings confirm the diagnostic value of urinary β-amyloid protein detection in MCI and AD-related dementia. +4 more findings

• Treatments
• Risk Factors

Scored 52 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

Full summary, score breakdown and related studies → Original source

Associations of gut bacterial classes Clostridia and Deltaproteobacteria with type 2 diabetes and Alzheimer’s disease: A two-sample Mendelian randomization study

39/100 ✓ Peer-reviewed Genetics Medicine

Key finding: Heterogeneity and directional pleiotropy were assessed, and IVW results were false discovery rate (FDR) corrected using Benjamini-Hochberg. +4 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer's disease

56/100 ✓ Peer-reviewed Genetics Nature Aging

Key finding: Together, these findings reveal that APOE2 and APOE4 shape Alzheimer's disease risk through distinct molecular architectures and identify candidate biomarkers and targets for allele-specific interventions.

• Genetics

Full summary, score breakdown and related studies → Original source