Newest studies

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

54/100 ✓ Peer-reviewed Genetics Nature reviews. Immunology

Key finding: The central nervous system (CNS) is separated from the blood circulation by the blood-brain barrier. +4 more findings

• Genetics
• Brain Biology

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Identifying Brain Connectivity Using Network-Based Statistics in Amnestic Mild Cognitive Impairment Stratified by β-Amyloid Positivity

46/100 ✓ Peer-reviewed Brain scans and imaging American journal of Alzheimer's disease and other dementias

Key finding: One hundred sixteen participants (Aβ- cognitively normal [CN], n = 35; Aβ- aMCI, n = 42; Aβ+ aMCI, n = 39) were included. +4 more findings

• Early Stage

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Progression in Vascular Cognitive Impairment: Pathogenesis, Neuroimaging Evaluation, and Treatment

41/100 ✓ Peer-reviewed Prevention trials Cell transplantation

Key finding: Vascular cognitive impairment (VCI) defines an entire spectrum of neurologic disorders from mild cognitive impairment to dementia caused by cerebral vascular disease. +4 more findings

• Brain Scans
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Editor’s view

44/100 ✓ Peer-reviewed Health systems and care delivery Age and Ageing

Key finding: Greater spend on social care (including availability of care home places) was associated with reduced spend in health care, with shorter length of hospital stay and decrease in readmissions. +1 more finding

• Care Services
• Clinical Trials

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Epidemiology of Whipple's Disease in the USA Between 2012 and 2017: A Population-Based National Study

41/100 ✓ Peer-reviewed Digital health tools Digestive diseases and sciences

Key finding: In this large population-based study, the overall prevalence of Whipple's disease in the USA is 9.8 cases per 1 million people. +3 more findings

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NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

41/100 ✓ Peer-reviewed Vascular contributions Redox biology

Key finding: A growing body of research data strongly suggests that imbalanced ROS and electrophile overproduction are among the major prodromal factors in the onset and progression of several cerebrovascular and neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), stroke, Alzheimer's disease (AD), Parkinson's disease (PD), and aging (Ma and He, 2012; Ramsey et al., 2017; Salminen et al., 2012; Sandberg et al., 2014; Sarlette et al., 2008; Tanji et al., 2013) [1-6].

• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

miR-34a in Neurophysiology and Neuropathology

38/100 ✓ Peer-reviewed Risk factors Journal of molecular neuroscience : MN

Key finding: Pathologically, its elevations during epileptic seizures and ischemic stroke contribute to neuronal injury and death. +4 more findings

• Brain Biology

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SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)

41/100 ✓ Peer-reviewed Treatments Alzheimer's research & therapy

Key finding: Based on the improved efficacy/safety profile in non-clinical models of SAR228810, a first-in-man single and multiple dose administration clinical study has been initiated in AD patients. +2 more findings

• Treatments
• Side Effects
• Brain Biology

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Current state of Alzheimer's fluid biomarkers

62/100 ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica

Key finding: The number of people living with AD is predicted to increase; however, there are no disease-modifying therapies currently available and none have been successful in late-stage clinical trials. +3 more findings

• Biomarkers
• Treatments

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Dementia Prevalence in Older Adults: Variation by Race/Ethnicity and Immigrant Status

54/100 ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Immigrant status may have complex effects on dementia risk. +4 more findings

• Health Equity

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Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity

47/100 ✓ Peer-reviewed Brain scans and imaging The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: In this subset, we found that inferior temporal tau accumulation was associated with increased fMRI activity in the hippocampus, but showed no clear association with amyloid. +2 more findings

• Brain Scans
• Early Stage

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Melatonin Rescue Oxidative Stress-Mediated Neuroinflammation/ Neurodegeneration and Memory Impairment in Scopolamine-Induced Amnesia Mice Model

38/100 ✓ Peer-reviewed Biomarkers Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

Key finding: Based on the potential neuroprotective effects of melatonin, we here explored the possible underlying mechanisms of the protective effect of melatonin against scopolamine-induced oxidative stress-mediated c-Jun N-terminal kinase (JNK) activation, which ultimately results in synaptic dysfunction, neuroinflammation, and neurodegeneration. +4 more findings

• Brain Biology

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Cognitive tests for the detection of mild cognitive impairment (MCI), the prodromal stage of dementia: Meta-analysis of diagnostic accuracy studies

63/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry

Key finding: Mild cognitive impairment (MCI) is regarded as a prodrome to dementia. +3 more findings

• Diagnosis
• Early Stage

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Redox proteomics and amyloid β-peptide: insights into Alzheimer disease

44/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of neurochemistry

Key finding: Alzheimer disease (AD) is a progressive neurodegenerative disorder associated with aging and characterized pathologically by the presence of senile plaques, neurofibrillary tangles, and neurite and synapse loss. +1 more finding

• Brain Biology

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In vivo molecular imaging of neuroinflammation in Alzheimer's disease

46/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of neurochemistry

Key finding: Increased glial cell activation is consistently reported in both rodent models of AD and in AD patients. +3 more findings

• Genetics
• Brain Biology

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Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

79/100 ✓ Peer-reviewed Prevention and risk The Lancet. Neurology

Key finding: We aimed to present the first detailed analysis of the global prevalence, mortality, and overall burden of dementia as captured by the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016, and highlight the most important messages for clinicians and neurologists. +1 more finding

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Levels of plasma neurofilament light chain and cognitive function in patients with Alzheimer or Parkinson disease

50/100 ✓ Peer-reviewed Biomarkers Scientific reports

Key finding: Plasma NFL was significantly increased in the AD group, compared with the control, MCI, PDND, and PDD groups. +1 more finding

• Biomarkers
• Other Dementias

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Baseline predictors for progression 4 years after Parkinson's disease diagnosis in the De Novo Parkinson Cohort (DeNoPa)

50/100 ✓ Peer-reviewed Hippocampus size on brain scans Movement disorders : official journal of the Movement Disorder Society

Key finding: Cardiovascular risk factors, deregulated blood glucose, uric acid metabolism, and inflammation were identified as risk markers for faster disease progression. +1 more finding

• Diagnosis
• Brain Scans
• Biomarkers

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TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism

44/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in aging neuroscience

Key finding: Recent genetic studies have identified rare variants of the gene encoding the triggering receptor expressed on myeloid cells-2 (TREM2) as significant genetic risk factors in late-onset AD (LOAD). +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Disease progression timeline estimation for Alzheimer's disease using discriminative event based modeling

45/100 ✓ Peer-reviewed Digital health tools NeuroImage

Key finding: We evaluated the proposed method on Alzheimer's Disease Neuroimaging Initiative (ADNI) data and compared the results with existing state-of-the-art EBM methods. +1 more finding

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Body, Brain, Life for Cognitive Decline (BBL-CD): protocol for a multidomain dementia risk reduction randomized controlled trial for subjective cognitive decline and mild cognitive impairment

69/100 ✓ Peer-reviewed Prevention trials Clinical interventions in aging

Key finding: Modifiable lifestyle risk factors have been identified as playing a major role in the development of dementia; hence, interventions addressing these risk factors represent a significant opportunity to reduce the number of people developing dementia. +1 more finding

• Clinical Trials
• Prevention
• Early Stage

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Inflammation in ALS/FTD pathogenesis

52/100 ✓ Peer-reviewed Inflammation and the immune system Acta neuropathologica

Key finding: In ALS/FTD patients, neuroinflammation characterized by innate immune responses of tissue-resident glial cells is uniformly present on end-stage pathology, and human imaging studies and rodent models support that neuroinflammation begins early in disease pathogenesis. +3 more findings

• Brain Biology

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Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease

38/100 ✓ Peer-reviewed Treatments Journal of neuroimmunology

Key finding: Compelling evidence suggests that neuroinflammation stimulated by microglia, the resident macrophage-like immune cells in the brain, play a contributing role in the pathogenesis of Alzheimer's disease (AD). +1 more finding

• Treatments
• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Multifactorial Examination of Caregiver Burden in a National Sample of Family and Unpaid Caregivers

51/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society

Key finding: Caregiver characteristics and provision of caregiving tasks determine caregiver burden more than care recipient characteristics. +4 more findings

• Caregiving

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The risks of long-term use of proton pump inhibitors: a critical review

43/100 ✓ Peer-reviewed Prevention and risk Therapeutic advances in drug safety

Key finding: At least one study has suggested that long-term PPI use increases the risk of dementia. +1 more finding

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