Newest studies

Interventions for subjective cognitive decline: systematic review and meta-analysis

69/100 ✓ Peer-reviewed Prevention trials BMJ open

Key finding: There is a lack of high-quality research in this field. +4 more findings

• Early Stage

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Liraglutide for psychiatric disorders: clinical evidence and challenges

39/100 ✓ Peer-reviewed Drug development Hormone molecular biology and clinical investigation

Key finding: Preliminary clinical evidence has suggested that liraglutide could decrease weight gain, improve cognition and prevent cognitive decline.

• Risk Factors

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Discovery and validation of autosomal dominant Alzheimer's disease mutations

39/100 ✓ Peer-reviewed Risk genes beyond APOE Alzheimer's research & therapy

Key finding: We propose that PSEN1 M84V, PSEN1 A396T, PSEN2 R284G, and APP T719N are likely pathogenic mutations, whereas PSEN1 c.379_382delXXXXinsG and PSEN2 L238F have uncertain pathogenicity. +2 more findings

• Genetics

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Transcranial direct current stimulation combined with cognitive training for the treatment of Parkinson Disease: A randomized, placebo-controlled study

66/100 ✓ Peer-reviewed Prevention trials Brain stimulation

Key finding: We concluded that cognitive training along with active tDCS is a useful combined approach in the management of mood and cognitive dysfunctions in PD. +3 more findings

• Clinical Trials
• Treatments
• Other Dementias

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Alzheimer disease pathology and the cerebrospinal fluid proteome

54/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

Key finding: Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid pathology, and tau-related neurodegeneration have not yet been fully explored. +3 more findings

• Biomarkers

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Sleep disturbances and dementia risk: A multicenter study

69/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02-1.50) and late-life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08-3.49) were associated with a higher dementia risk. +2 more findings

• Risk Factors
• Lifestyle

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Left lateralized cerebral glucose metabolism declines in amyloid-β positive persons with mild cognitive impairment

55/100 ✓ Peer-reviewed Long-term cohort studies NeuroImage. Clinical

Key finding: Previous publications indicate that Alzheimer's Disease (AD) related cortical atrophy may develop in asymmetric patterns, with accentuation of the left hemisphere. +3 more findings

• Early Stage
• Brain Scans

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The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders

53/100 ✓ Peer-reviewed TREM2 and immune genetics The Lancet. Neurology

Key finding: TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and its association with Alzheimer's disease supports the involvement of immune and inflammatory pathways in the cause of the disease, rather than as a consequence of the disease. +3 more findings

• Genetics
• Brain Biology

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Transplanted neural-like cells improve memory and Alzheimer-like pathology in a rat model

32/100 ✓ Peer-reviewed Biomarkers Cytotherapy

Key finding: It should be noted that by improving the neuronal connectivity in AM rat brains, the transplanted NLCs rescue Alzheimer's cognition.

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Nutritional Interventions as Beneficial Strategies to Delay Cognitive Decline in Healthy Older Individuals

41/100 ✓ Peer-reviewed Prevention trials Nutrients

Key finding: Current demographic trends indicate that the population is aging. +2 more findings

• Lifestyle

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Cohort Profile Update: The Irish Longitudinal Study on Ageing (TILDA)

71/100 ✓ Peer-reviewed End-of-life care International Journal of Epidemiology

Key finding: As outlined in the original cohort profile,1 The Irish Longitudinal Study on Ageing (TILDA) is a prospective cohort study designed to provide an evidence base for addressing the challenges and opportunities associated with population ageing in Ireland. +3 more findings

• Risk Factors

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Involvement of Hospitalized Persons With Dementia in Everyday Decisions: A Dyadic Study

46/100 ✓ Peer-reviewed Caregiving The Gerontologist

Key finding: Both members of the dyad rated the PWD, on average, as being "somewhat involved". +4 more findings

• Caregiving

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Brain-wide glymphatic enhancement and clearance in humans assessed with MRI

54/100 ✓ Peer-reviewed How common it is JCI insight

Key finding: Standardized T1-weighted MRI scans were performed before and after intrathecal gadobutrol at defined time points, including at 24 hours, 48 hours, and 4 weeks. +4 more findings

• Brain Scans

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A molecular approach in drug development for Alzheimer's disease

39/100 ✓ Peer-reviewed Treatments Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Key finding: An increase in dementia numbers and global trends in population aging across the world prompts the need for new medications to treat the complex biological dysfunctions, such as neurodegeneration associated with dementia.

• Treatments

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How can a measure improve assessment and management of symptoms and concerns for people with dementia in care homes? A mixed-methods feasibility and process evaluation of IPOS-Dem

45/100 ✓ Peer-reviewed End-of-life care PloS one

Key finding: Key mechanisms of action were: improved observation and awareness of residents, collaborative assessment, comprehensive 'picture of the person', systematic record keeping, improved review and monitoring, care planning and changes to care provision, and facilitated multi-agency communication.

• Care Services

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Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

47/100 ✓ Peer-reviewed Biomarkers Redox biology

Key finding: Daily oral gavage of DMF during six weeks reduced glial and inflammatory markers and improved cognition and motor complications in the AT-NRF2-WT mice compared with the vehicle-treated animals.

• Brain Biology

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Patient perspectives of the experience of a computerized cognitive assessment in a clinical setting

45/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (New York, N. Y.)

Key finding: Careful design and user-testing should be made a priority in the development of computerized assessment interfaces, as well as reevaluating the cognitive assessment process to minimize patient anxiety and discomfort. +1 more finding

• Diagnosis
• Digital Tools

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Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance

39/100 ✓ Peer-reviewed Disease mechanisms Oxidative medicine and cellular longevity

Key finding: Its etiological pathways are not well defined, although many contributory mechanisms have been established. +4 more findings

• Brain Biology

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A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

43/100 ✓ Peer-reviewed Genetics Molecular psychiatry

Key finding: Subsequent genotyping and analysis of available whole-exome sequencing data of additional case/control samples from Germany, UK, and USA identified five variant carriers among AD patients only. +4 more findings

• Genetics

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Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease

38/100 ✓ Peer-reviewed Lewy body dementia Nature nanotechnology

Key finding: Though emerging evidence indicates that the pathogenesis of Parkinson's disease is strongly correlated to the accumulation 1,2 and transmission 3,4 of α-synuclein (α-syn) aggregates in the midbrain, no anti-aggregation agents have been successful at treating the disease in the clinic.

• Other Dementias
• Brain Biology
• Prevention

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CogChamps: impact of a project to educate nurses about delirium and improve the quality of care for hospitalized patients with cognitive impairment

39/100 ✓ Peer-reviewed Health systems and care delivery BMC Health Services Research

Key finding: Observational and audit data were collected for 181 patients (average age = 82.5 years) across the two hospitals. +4 more findings

• Care Services

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TREM2-Dependent Effects on Microglia in Alzheimer's Disease

46/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in aging neuroscience

Key finding: Abnormal protein aggregates in the AD brain are also associated with reactive microglia and astrocytes. +3 more findings

• Brain Biology
• Genetics

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Unsupervised Machine Learning to Identify High Likelihood of Dementia in Population-Based Surveys: Development and Validation Study

59/100 ✓ Peer-reviewed Digital health tools Journal of medical Internet research

Key finding: Unsupervised machine learning identifies high likelihood of dementia in population-based surveys, even without cognitive and behavioral measures and without the need of clinical diagnosis of dementia in a subsample of the population. +1 more finding

• Digital Tools

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Klotho at the Edge of Alzheimer's Disease and Senile Depression

39/100 ✓ Peer-reviewed Risk factors Molecular neurobiology

Key finding: Klotho, encoded by the KL gene, is a single-pass transmembrane protein and a circulating factor that plays a key role in cellular metabolism and body homeostasis and has been associated with age-related diseases.

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Strong Circadian Rhythms in the Choroid Plexus: Implications for Sleep-Independent Brain Metabolite Clearance

39/100 ✓ Peer-reviewed Risk factors Journal of experimental neuroscience

Key finding: CSF dilutes metabolites from neuronal activities and removes them from the brain. +4 more findings

• Lifestyle

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