Absolute 10-year risk of dementia by age, sex and APOE genotype: a population-based cohort study
Rasmussen KL, Tybjærg-Hansen A, Nordestgaard BG, Frikke-Schmidt R.. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2018-09-01
Topic: Risk, prevention and care in population studies
Background Dementia is a major cause of disability, and risk-factor reduction may have the potential to delay or prevent the disease. Our aim was to determine the absolute 10-year risk of dementia, by age, sex and apolipoprotein E ( APOE ) genotype. Methods We obtained data from the Copenhagen General Population Study (from 2003 to 2014) and the Copenhagen City Heart Study (from 1991 to 1994 and 2001 to 2003). Participants underwent a questionnaire, physical examination and blood sampling at baseline. Diagnoses of dementia and cerebrovascular disease were obtained from the Danish National Patient Registry up to Nov. 10, 2014. Results Among 104 537 individuals, the absolute 10-year risk of Alzheimer disease in 3017 women and men who were carriers of the APOE ɛ44 genotype was, respectively, 7% and 6% at age 60-69 years, 16% and 12% at age 70-79 years, and 24% and 19% at age 80 years and older. Corresponding values for all dementia were 10% and 8%, 22% and 19%, and 38% and 33%, respectively. Adjusted hazard ratios (HRs) for all dementia increased by genotype, from genotype ɛ22 to ɛ32 to ɛ33 to ɛ42 to ɛ43 to ɛ44 ( p for trend Interpretation Age, sex and APOE genotype robustly identify high-risk groups for Alzheimer disease and all dementia. These groups can potentially be targeted for preventive interventions.
Key findings
- Results Among 104 537 individuals, the absolute 10-year risk of Alzheimer disease in 3017 women and men who were carriers of the APOE ɛ44 genotype was, respectively, 7% and 6% at age 60-69 years, 16% and 12% at age 70-79 years, and 24% and 19% at age 80 years and older.
Why it matters
This population study calculated the 10-year risk of Alzheimer disease and other dementias by age, sex and APOE genotype, finding the highest risks in APOE ɛ44 carriers. The authors suggest these high-risk groups could be targeted for preventive interventions, but the study itself tested no prevention.
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Study details
- Participants537
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, so that was left out: it earned 47 of the 96 points we could judge it on, which is 49 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 537 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 93 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.3 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 3 / 6 | Cited 7.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 24 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Ruth Frikke‐Schmidt: h-index 65 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Rigshospitalet: institution h-index 882 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30181149) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 47 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 47 of the 96 points we could judge it on is 49 out of 100. |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
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APA 7th
Rasmussen, K. L., Tybjærg-Hansen, A., Nordestgaard, B. G., & Frikke-Schmidt, R. (2018). Absolute 10-year risk of dementia by age, sex and APOE genotype: a population-based cohort study. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. https://doi.org/10.1503/cmaj.180066
Vancouver
Rasmussen KL, Tybjærg-Hansen A, Nordestgaard BG, Frikke-Schmidt R. Absolute 10-year risk of dementia by age, sex and APOE genotype: a population-based cohort study. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2018. doi:10.1503/cmaj.180066. PMID: 30181149.
BibTeX
@article{rasmussen2018-30181149,
author = {Rasmussen, K. L. and Tybjærg-Hansen, A. and Nordestgaard, B. G. and Frikke-Schmidt, R.},
title = {{Absolute 10-year risk of dementia by age, sex and APOE genotype: a population-based cohort study}},
journal = {CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne},
year = {2018},
doi = {10.1503/cmaj.180066},
pmid = {30181149},
url = {https://doi.org/10.1503/cmaj.180066}
}
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