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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 16,201–16,225 of 27,380 studies, newest first · page 649 of 1096.

March 2016 25

  1. 2016-03-29

    The amyloid hypothesis of Alzheimer's disease at 25 years

    ✓ Peer-reviewed Disease mechanisms EMBO Molecular Medicine

    Key finding: The human oligomers also induce hyperphosphorylation of tau at AD-relevant epitopes and cause neuritic dystrophy in cultured neurons. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2016-03-29

    Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease

    ✓ Peer-reviewed Long-term cohort studies Molecular psychiatry

    Key finding: Although beta-amyloid is necessary for the pathologic diagnosis of AD, it is not sufficient to make the pathologic diagnosis or cause dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2016-03-29

    APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

    ✓ Peer-reviewed Genetics Annals of neurology

    Key finding: APOE2 is associated with less cognitive decline during aging. +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2016-03-26

    Gait variability in people with neurological disorders: A systematic review and meta-analysis

    ✓ Peer-reviewed Digital health tools Human movement science

    Key finding: All pathological groups had increased amount of gait variability and loss of fractal structure of gait dynamics compared to healthy controls, and gait variability differentiated distinctive neurological conditions.

    Full summary, score breakdown and related studies → Original source

  5. 2016-03-25

    Higher C-Reactive Protein Levels Predict Postoperative Delirium in Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study

    ✓ Peer-reviewed Clinical safety Biological psychiatry

    Key finding: Elevated preoperative and postoperative plasma levels of C-reactive protein were associated with delirium, suggesting that a preinflammatory state and heightened inflammatory response to surgery are potential pathophysiologic mechanisms of delirium. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2016-03-25

    Dura mater is a potential source of Aβ seeds

    ✓ Peer-reviewed Genetics Acta neuropathologica

    Key finding: However, in contrast to prion diseases, our study suggests that such Aβ seeding is unable to reproduce the full clinicopathological phenotype of AD.

    Full summary, score breakdown and related studies → Original source

  7. 2016-03-24

    Molecular genetics of early-onset Alzheimer's disease revisited

    ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: To conclude, we commented on the relevance of reinvestigating EOAD patients as a means to explore potential new avenues for translational research and therapeutic discoveries.

    Full summary, score breakdown and related studies → Original source

  8. 2016-03-24

    Discussing end-of-life issues in nursing homes: a nationwide study in France

    ✓ Peer-reviewed End-of-life care Age and ageing

    Key finding: Residents who died from non-sudden causes between 1 October 2013 and 31 May 2014 in these facilities were included (n = 674). +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2016-03-23

    Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants

    ✓ Peer-reviewed Genetics Aging

    Key finding: In GWAS, a nicotine receptor locus(CHRNA3, previously associated with increased smoking and lung cancer) was associated with fathers' survival. +2 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2016-03-23

    The importance of understanding individual differences in Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's F1000Research

    Key finding: We argue that, in the context of significant increases in DS life expectancy, a focus on individual differences in trisomy 21 at all levels-genetic, cellular, neural, cognitive, behavioral, and environmental-constitutes one of the best approaches for understanding genotype/phenotype relations in DS and for exploring risk and protective factors for Alzheimer's disease in this high-risk population.

    Full summary, score breakdown and related studies → Original source

  11. 2016-03-23

    The role of interleukin-6 signaling in nervous tissue

    ✓ Peer-reviewed Brain scans and imaging Biochimica et biophysica acta

    Key finding: Profound neuropathological changes, such as multiple sclerosis (MS), Parkinson's and Alzheimer's disease are associated with increased IL-6 expression in brain. +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2016-03-23

    ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials

    ✓ Peer-reviewed Mild cognitive impairment Journal of neurology, neurosurgery, and psychiatry

    Key finding: ADCOMS is proposed as new standard outcome for pAD and mild AD dementia trials, and is progressing in a CAMD-sponsored qualification process for use in registration trials of pAD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2016-03-22

    Hippocampal Pathway Plasticity Is Associated with the Ability to Form Novel Memories in Older Adults

    ✓ Peer-reviewed Prevention trials Frontiers in aging neuroscience

    Key finding: The fornix as main efferent hippocampal pathway is one of the tracts most strongly associated with age-related memory impairment. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2016-03-22

    Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise

    ✓ Peer-reviewed Mild cognitive impairment Molecular psychiatry

    Key finding: We found that PRT but not CCT significantly improved global cognition (F(90)=4.1, P corrected <0.05), and these changes were related to each other (r=0.25, P=0.03). +2 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2016-03-22

    Gender differences in caregiving among family - caregivers of people with mental illnesses

    ✓ Peer-reviewed Caregiving World journal of psychiatry

    Key finding: It has been suggested that there are several societal and cultural demands on women to adopt the role of a family-caregiver. +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2016-03-21

    Single subject prediction of brain disorders in neuroimaging: Promises and pitfalls

    ✓ Peer-reviewed Digital health tools NeuroImage

    Key finding: Moreover, emerging trends such as decentralized data sharing, multimodal brain imaging, differential diagnosis, disease subtype classification and deep learning are also discussed. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2016-03-21

    C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

    ✓ Peer-reviewed Brain tissue and pathology Nature neuroscience

    Key finding: To investigate poly(GA) toxicity, we generated mice that exhibit poly(GA) pathology, neurodegeneration and behavioral abnormalities reminiscent of FTD and ALS. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2016-03-19

    Temporal Trends and Geographic Variations in Dementia Mortality in China Between 2006 and 2012

    ✓ Peer-reviewed Risk factors Alzheimer Disease & Associated Disorders

    Key finding: Dementia mortality varied over 2-fold between DSPs (median rate ratio: 2.59). +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2016-03-18

    Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases

    ✓ Peer-reviewed Risk factors Cellular and molecular neurobiology

    Key finding: The lymphatic clearance pathways of the brain are different compared to the other organs of the body and have been the subject of heated debates. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2016-03-18

    A Feasibility Study with Image-Based Rendered Virtual Reality in Patients with Mild Cognitive Impairment and Dementia

    ✓ Peer-reviewed Prevention trials PloS one

    Key finding: Virtual Reality (VR) has emerged as a promising tool in many domains of therapy and rehabilitation, and has recently attracted the attention of researchers and clinicians working with elderly people with MCI, Alzheimer's disease and related disorders. +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2016-03-17

    Behavioural and psychological symptoms in dementia and the challenges for family carers: systematic review

    ✓ Peer-reviewed Caregiving The British journal of psychiatry : the journal of mental science

    Key finding: Family carers' perceptions of BPSD as challenging are associated with a sense of a declining relationship, transgressions against social norms and underlying beliefs that people with dementia inevitably lose their 'personhood'. +1 more finding

    Full summary, score breakdown and related studies → Original source

  22. 2016-03-16

    Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Nature

    Key finding: Here we show that in transgenic mouse models of early AD, direct optogenetic activation of hippocampal memory engram cells results in memory retrieval despite the fact that these mice are amnesic in long-term memory tests when natural recall cues are used, revealing a retrieval, rather than a storage impairment.

    Full summary, score breakdown and related studies → Original source

  23. 2016-03-16

    The blood-brain barrier in systemic inflammation

    ✓ Peer-reviewed Vascular contributions Brain, behavior, and immunity

    Key finding: We review emerging evidence for two novel concepts: (1) a heightened sensitivity of the diseased, versus healthy, BBB to systemic inflammation, and (2) the contribution of BBB changes induced by systemic inflammation to progression of the primary disease process.

    Full summary, score breakdown and related studies → Original source

  24. 2016-03-16

    Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes

    ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica communications

    Key finding: Alzheimer's disease (AD) is associated with the accumulation of β-amyloid (Aβ) as senile plaques in the brain, thus leading to neurodegeneration and cognitive impairment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2016-03-16

    Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

    ✓ Peer-reviewed TREM2 and immune genetics Neurobiology of aging

    Key finding: Interestingly, a missense variant in TREM-like transcript 2 (TREML2), a structurally similar protein encoded by the same gene cluster with TREM2 on chromosome 6, has been shown to protect against AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →