Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 13,076–13,100 of 27,380 studies, newest first · page 524 of 1096.
March 2019 20
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2019-03-01
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy
38/100 ✓ Peer-reviewed Disease mechanisms Science translational medicine
Key finding: Direct reduction of Rhes in the rTg4510 mouse by siRNA reproduced the results observed with lonafarnib treatment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-03-01
2019 Alzheimer's disease facts and figures
50/100 ✓ Peer-reviewed How common it is Alzheimer s & Dementia
Between 2000 and 2017, deaths resulting from stroke, heart disease, and prostate cancer decreased, whereas reported deaths from AD increased 145%.
Full summary, score breakdown and related studies → Original source
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2019-03-01
Street Network Models and Measures for Every U.S. City, County, Urbanized Area, Census Tract, and Zillow-Defined Neighborhood
32/100 ✓ Peer-reviewed Risk factors Urban Science
Key finding: This paper reports results from a research project that collected raw street network data from OpenStreetMap using the Python-based OSMnx software for every U.S. city and town, county, urbanized area, census tract, and Zillow-defined neighborhood.
Full summary, score breakdown and related studies → Original source
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2019-03-01
Street Network Models and Measures for Every U.S. City, County, Urbanized Area, Census Tract, and Zillow-Defined Neighborhood
33/100 ✓ Peer-reviewed Risk factors Not indexed
Key finding: This paper reports results from a research project that collected raw street network data from OpenStreetMap using the Python-based OSMnx software for every U.S. city and town, county, urbanized area, census tract, and Zillow-defined neighborhood.
Full summary, score breakdown and related studies → Original source
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2019-03-01
Assessment of Vascular Event Prevention and Cognitive Function Among Older Adults With Preexisting Vascular Disease or Diabetes
53/100 ✓ Peer-reviewed Health systems and care delivery JAMA Network Open
Key finding: Among 45 029 participants undergoing cognitive assessment, mean (SD) age was 67.9 (8.0) years; 80.7% were men. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Individual goal-oriented cognitive rehabilitation to improve everyday functioning for people with early-stage dementia: A multicentre randomised controlled trial (the GREAT trial)
72/100 ✓ Peer-reviewed Cognitive tests and assessment International journal of geriatric psychiatry
Key finding: Participants allocated to CR received 10 weekly sessions over 3 months and four maintenance sessions over 6 months. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry
55/100 ✓ Peer-reviewed TREM2 and immune genetics JAMA network open
Key finding: Some of the unexplained heritability of Alzheimer disease (AD) may be due to rare variants whose effects are not captured in genome-wide association studies because very large samples are needed to observe statistically significant associations. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
57/100 ✓ Peer-reviewed Mild cognitive impairment Nature reviews. Neuroscience
Key finding: Consequently, ATP-requiring processes for cognitive function are impaired, and synaptic dysfunction and neuronal death result, with ensuing thinning of key brain areas.
Full summary, score breakdown and related studies → Original source
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2019-03-01
Dementia in Down syndrome: unique insights for Alzheimer disease research
60/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Nature reviews. Neurology
Key finding: This association is partially due to overexpression of amyloid precursor protein, encoded by APP, as a result of the location of this gene on chromosome 21. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-03-01
High Cortisol and the Risk of Dementia and Alzheimer's Disease: A Review of the Literature
53/100 ✓ Peer-reviewed Risk factors Frontiers in aging neuroscience
Key finding: Clinical studies found that elevated cortisol was associated with poorer overall cognitive functioning, as well as with poorer episodic memory, executive functioning, language, spatial memory, processing speed, and social cognition; while in animals, glucocorticoid administration resulted in cognitive impairment and abnormal behavior. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Neurovascular and Cognitive Dysfunction in Hypertension
54/100 ✓ Peer-reviewed Risk factors Circulation research
Key finding: Long known to be associated with dementia caused by vascular factors, hypertension has more recently been linked also to Alzheimer disease-the major cause of dementia in older people.
Full summary, score breakdown and related studies → Original source
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2019-03-01
Language Performance of Individuals at Risk for Mild Cognitive Impairment
46/100 ✓ Peer-reviewed Digital health tools Journal of speech, language, and hearing research : JSLHR
Key finding: Language performance deficits can appear early before impairment in episodic memory, visuospatial construction ability, or mental status in individuals at risk for MCI. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study
73/100 ✓ Peer-reviewed How common it is Brain : a journal of neurology
Key finding: The overall conversion rate from iRBD to an overt neurodegenerative syndrome was 6.3% per year, with 73.5% converting after 12-year follow-up. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Dementia Mortality in the United States, 2000-2017
48/100 ✓ Peer-reviewed Disparities National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System
Key finding: In 2017, a total of 261,914 deaths attributable to dementia as an underlying cause of death were reported in the United States. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Racial/Ethnic and Nativity Differences in Cognitive Life Expectancies Among Older Adults in the United States
38/100 ✓ Peer-reviewed Disparities The Gerontologist
Key finding: Among women, the number of years spent living with dementia for Whites, Blacks, U.S.-born Hispanics, and foreign-born Hispanics was 1.6, 3.9, 4.7, and 6.0 years, respectively. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Comparison of Methods for Algorithmic Classification of Dementia Status in the Health and Retirement Study
48/100 ✓ Peer-reviewed Disparities Epidemiology (Cambridge, Mass.)
Key finding: Algorithmic diagnoses provide a cost-effective way to conduct dementia research. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Correlation of In Vivo [18F]Flortaucipir With Postmortem Alzheimer Disease Tau Pathology
52/100 ✓ Peer-reviewed Brain scans and imaging JAMA neurology
Key finding: In this patient, the clinical disease symptoms progressed rapidly in life, paralleled with an annual increase of tau PET retention of 20% to 40% in many cortical regions. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
The Alzheimer's Disease Clinical Spectrum: Diagnosis and Management
54/100 ✓ Peer-reviewed Getting a diagnosis The Medical clinics of North America
Key finding: Evaluation involves structured patient and caregiver history and symptom-function reviews, examination, and testing (laboratory and neuroimaging) to delineate impairment level, determine the cognitive-behavioral syndrome, and diagnose cause. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Assessment of Racial Disparities in Biomarkers for Alzheimer Disease
67/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: There were no racial differences in the frequency of cerebral ischemic lesions noted on results of brain magnetic resonance imaging, mean cortical standardized uptake value ratios for Pittsburgh compound B, or for amyloid-β42 concentrations in CSF. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-03-01
Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders
68/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: Cognitive testing follow-up occurred for 1 to 18 years (mean [SD], 0.98 [2.25] years); autopsy-verified diagnoses were available for 120 of 845 participants with diseases (14.2%). +1 more finding
Full summary, score breakdown and related studies → Original source
February 2019 5
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2019-02-28
Social networks and loneliness in people with Alzheimer's dementia
46/100 ✓ Peer-reviewed Risk factors International journal of geriatric psychiatry
Key finding: The friendship subset of social networks was significantly related to cognition (independent of age, gender, depression, loneliness, and family subset of social network): B = 0.284, P = 0.01. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-02-28
Liraglutide and its Neuroprotective Properties-Focus on Possible Biochemical Mechanisms in Alzheimer's Disease and Cerebral Ischemic Events
41/100 ✓ Peer-reviewed Drug development International journal of molecular sciences
Key finding: The literature starts to suggest that liraglutide may reduce the effects of ischemic stroke by activating anti-apoptotic pathways, as well as limiting the harmful effects of free radicals.
Full summary, score breakdown and related studies → Original source
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2019-02-28
Fructooligosaccharides Ameliorating Cognitive Deficits and Neurodegeneration in APP/PS1 Transgenic Mice through Modulating Gut Microbiota
38/100 ✓ Peer-reviewed Drug development Journal of agricultural and food chemistry
Key finding: The results indicated that FOS treatment ameliorated cognitive deficits and pathological changes in the Tg mice. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-02-28
Treatment patterns and burden of behavioral disturbances in patients with dementia in the United States: a claims database analysis
57/100 ✓ Peer-reviewed End-of-life care BMC neurology
Key finding: Patients with dementia with BD had a higher prevalence of comorbidities, greater use of comedications, and greater healthcare utilization and costs than patients with dementia without BD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-02-28
MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study
60/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Preliminary evidence suggests that protective effects of the MIND diet are geographically generalizable. +1 more finding
Full summary, score breakdown and related studies → Original source
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