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Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial
Lilamand M, Cesari M, Cantet C, Payoux P, Andrieu S, Vellas B, the MAPT/DSA study group.. Journal of the American Geriatrics Society, 2018-09-12
Topic: Amyloid, tau and blood-test diagnosis
Objectives To examine the evolution of instrumental activity of daily living (IADL) performance according to the presence of brain amyloid deposition. Design Longitudinal analysis of a randomized controlled trial. Setting Neuroimaging ancillary study from the Multidomain Alzheimer Prevention Trial (MAPT). Participants Community-dwelling individuals aged 70 and older without dementia (N = 269; 60% female, mean age 75±4). Measurements Linear mixed models were used to assess the 36-month evolution of the performance of an IADL questionnaire for primary prevention studies in dementia, the Activity of Daily Living Prevention Instrument (ADL-PI), according to the presence of amyloid deposition using florbetapir positron emission tomography (PET) (standardized uptake value≥1.17). Additional analyses were also conducted to examine the changes in specific domains of daily functioning with and without adjustment for age, sex, apolipoprotein E, randomization group, and time between baseline and PET examination. Results One hundred two (37.9%) participants were amyloid positive. Amyloid-negative participants had statistically significant improvement in ADL-PI total score between baseline and 36 months (p=.04). The difference after 3 years between amyloid-positive and -negative participants was not significant (β=-0.95±0.53 at 36 months, p=.08; adjusted models: β=-1.07±0.56, p=.06). Amyloid-negative participants also improved in memory-related IADLs (p Conclusion Amyloid-positive and -negative older adults are likely to have different trajectories in IADL performance. Future research is needed to better understand the relationship between amyloid plaques and functional limitations.
Key findings
- Results One hundred two (37.9%) participants were amyloid positive.
- Amyloid-negative participants had statistically significant improvement in ADL-PI total score between baseline and 36 months (p=.04).
- The difference after 3 years between amyloid-positive and -negative participants was not significant (β=-0.95±0.53 at 36 months, p=.08; adjusted models: β=-1.07±0.56, p=.06).
Why it matters
In 269 older adults without dementia, those without brain amyloid showed improvement in daily activity scores over 36 months, but the difference between amyloid-positive and amyloid-negative participants was not significant. This means amyloid status was not clearly linked to changes in daily functioning in this group.
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Study details
- Study designrandomized controlled trial
- Participants269
- Effect size37.9%
- Evidence strengthHigh
How this study scored 61/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. We have no data on senior author's track record, so that was left out: it earned 59 of the 96 points we could judge it on, which is 61 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Geriatrics Society) |
| Journal's citation record | 3 / 4 | Journal of the American Geriatrics Society: journal h-index 344 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 269 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 2 / 7 | Cited 13 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.3 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 1 / 6 | Cited 0.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 10 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30207586) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 59 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 59 of the 96 points we could judge it on is 61 out of 100. |
| Total | 61 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Lilamand, M., Cesari, M., Cantet, C., Payoux, P., Andrieu, S., Vellas, B., et al. (2018). Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.15497
Vancouver
Lilamand M, Cesari M, Cantet C, Payoux P, Andrieu S, Vellas B, et al. Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial. Journal of the American Geriatrics Society. 2018. doi:10.1111/jgs.15497. PMID: 30207586.
BibTeX
@article{lilamand2018-30207586,
author = {Lilamand, M. and Cesari, M. and Cantet, C. and Payoux, P. and Andrieu, S. and Vellas, B. and {the MAPT/DSA study group}},
title = {{Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial}},
journal = {Journal of the American Geriatrics Society},
year = {2018},
doi = {10.1111/jgs.15497},
pmid = {30207586},
url = {https://doi.org/10.1111/jgs.15497}
}
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