Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,401–12,425 of 27,380 studies, newest first · page 497 of 1096.
October 2019 25
-
2019-10-16
Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases
38/100 ✓ Peer-reviewed Disease mechanisms Neurobiology of disease
Key finding: Accumulating evidence from preclinical and clinical research indicate that gut microbiota, and their associated microbiomes, may influence pathogenic processes and thus the onset and progression of various diseases, including neurological and psychiatric disorders. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2019-10-16
Prediction and Classification of Alzheimer's Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers
55/100 ✓ Peer-reviewed Digital health tools Frontiers in computational neuroscience
Key finding: As a result, our combined method achieved an area under the receiver operating characteristic (AU-ROC) curve of 98.33, 93.59, 96.83, 94.64, 96.43, and 95.24% for AD vs. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2019-10-15
Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study
56/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia (New York, N. Y.)
Key finding: In each cohort, achieving just 10-21.4 min/day moderate-to-vigorous PA related to better executive function ( P P = .02). +2 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-15
Common risk factors for major noncommunicable disease, a systematic overview of reviews and commentary: the implied potential for targeted risk reduction
48/100 ✓ Peer-reviewed Prevention and risk Therapeutic advances in chronic disease
Key finding: Research linking clinical and lifestyle risk factors to increased risk of noncommunicable disease is now well established with examples of confirmed risk factors, including smoking, physical inactivity, obesity and hypertension. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2019-10-14
Head-to-head comparison of tau positron emission tomography tracers [18F]flortaucipir and [18F]RO948
46/100 ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging
Key finding: Neocortical tracer retention was highly comparable using both SUVR and distribution volume ratio-1 values obtained from dynamic scans. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-14
Development and Validation of eRADAR: A Tool Using EHR Data to Detect Unrecognized Dementia
64/100 ✓ Peer-reviewed Digital health tools Journal of the American Geriatrics Society
Key finding: The eRADAR tool uses existing EHR data to detect patients with good accuracy who may have unrecognized dementia.
Full summary, score breakdown and related studies → Original source
-
2019-10-14
Interdisciplinary palliative care for people with advanced Parkinson's disease: a view from the home
43/100 ✓ Peer-reviewed End-of-life care Annals of palliative medicine
Key finding: As our population ages, therapies increase, and the number of individuals living with advanced PD and related disorders grows, so too does the imperative to recognize and address the palliative care needs of such patients and families.
Full summary, score breakdown and related studies → Original source
-
2019-10-14
Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer's Disease
41/100 ✓ Peer-reviewed End-of-life care International journal of molecular sciences
Key finding: The reason behind such imperfect drugs may result from the inefficiencies of the current drugs to target the cause of the disease.
Full summary, score breakdown and related studies → Original source
-
2019-10-14
Trends and Factors Associated with Place of Death for Individuals with Dementia in the United States
53/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: As ADRD deaths at home increase, the need for caregiver support and home-based palliative care may become more critical. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-14
Amyloid PET Quantification Via End-to-End Training of a Deep Learning
36/100 ✓ Peer-reviewed Biomarkers Nuclear medicine and molecular imaging
Key finding: We suggest a one-step quantification method for amyloid PET via a deep learning model.
Full summary, score breakdown and related studies → Original source
-
2019-10-13
Functional ability is associated with higher adherence to behavioral interventions in mild cognitive impairment
47/100 ✓ Peer-reviewed Cognitive tests and assessment The Clinical neuropsychologist
Key finding: Two-hundred and thirty-seven participants completed the 6-month post-intervention follow-up measures, 228 participants completed the 12-month measures, and 218 participants completed the 18-month measures. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-13
Predicting incident dementia 3-8 years after brief cognitive tests in the UK Biobank prospective study of 500,000 people
54/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Prospective studies reporting associations between cognitive performance and subsequent incident dementia have been subject to attrition bias. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-12
Familial Alzheimer's disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability
41/100 ✓ Peer-reviewed Risk genes beyond APOE Aging clinical and experimental research
Key finding: By generating novel tools for measuring Ca2+ in living cells, and combining different approaches, we showed that FAD-linked PS2 mutants significantly alter cell Ca2+ signaling and brain network activity, as summarized below.
Full summary, score breakdown and related studies → Original source
-
2019-10-12
Pain Assessment in the Patient Unable to Self-Report: Clinical Practice Recommendations in Support of the ASPMN 2019 Position Statement
38/100 ✓ Peer-reviewed End-of-life care Pain management nursing : official journal of the American Society of Pain Management Nurses
Key finding: Pain is a subjective experience, unfortunately, some patients cannot provide a self-report of pain verbally, in writing, or by other means. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-10
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model
41/100 ✓ Peer-reviewed Genetics The Journal of Experimental Medicine
Key finding: However, to what degree innate immunity contributes to neurodegeneration as compared with pathological protein-induced neurotoxicity, and the requirement of a particular glial cell type in neurodegeneration, are still unclear. +2 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-10
"A priori" Dietary Patterns and Cognitive Function in the SUN Project
52/100 ✓ Peer-reviewed Prevention and risk Neuroepidemiology
Key finding: Adjusted differences showed advantages in the 6-year change in STICS-m score of 0.25 (95% CI 0.04-0.45) for an increase of 1-SD (9 points) in the AHEI-2010 and of 0.27 (95% CI 0.05-0.48) for an increase of 1-SD (1.5 points) in the MIND diet. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-10
Pathogenetic pathways of cognitive dysfunction and dementia in metabolic syndrome
68/100 ✓ Peer-reviewed Risk factors Life sciences
Key finding: A number of studies and meta-analyses have provided evidence for increased risk of dementia in patients with metabolic syndrome (MS) as compared to persons without MS.
Full summary, score breakdown and related studies → Original source
-
2019-10-10
Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk
49/100 ✓ Peer-reviewed TREM2 and immune genetics Brain communications
Key finding: Using transgenic mouse models of amyloid deposition, we previously showed that many of the mouse orthologues of these risk genes are co-expressed and associated with amyloid pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-10
Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities
46/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in cellular neuroscience
Key finding: We have employed an ectopic model of TREM2 and DAP12 expression in HEK293 cells to study selectively TREM2 dependent signaling and phagocytic functions and evaluated the effects of some of the TREM2 mutations associated with AD. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-10
Causal Effect of Lp(a) [Lipoprotein(a)] Level on Ischemic Stroke and Alzheimer Disease: A Mendelian Randomization Study
47/100 ✓ Peer-reviewed Genetics Stroke
Key finding: This study provides evidence to support that high Lp(a) concentrations was causally associated with an increased risk of large artery stroke but a decreased risk of small vessel stroke and Alzheimer disease. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-09
Resolving the fibrotic niche of human liver cirrhosis at single-cell level
64/100 ✓ Peer-reviewed TREM2 and immune genetics Nature
Key finding: There are currently no effective antifibrotic therapies available. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-08
Statistical methods for dementia risk prediction and recommendations for future work: A systematic review
44/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia (New York, N. Y.)
Key finding: We identified three major methodological weaknesses: (1) over-reliance on one data source, (2) poor verification of statistical assumptions of Cox and logistic regression, and (3) lack of validation.
Full summary, score breakdown and related studies → Original source
-
2019-10-08
Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living With Mild to Moderate Alzheimer's Disease: Results From NILVAD
64/100 ✓ Peer-reviewed Treatments Journal of the American Medical Directors Association
Key finding: This study found no effect of ongoing BDZR use on ADAS-Cog scores in those with mild to moderate AD over 18 months. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-07
A combined miRNA-piRNA signature to detect Alzheimer's disease
46/100 ✓ Peer-reviewed Biomarkers Translational psychiatry
Key finding: In this study, we use next-generation sequencing to study the small noncoding RNAome (sncRNAome) in exosomes derived from human cerebrospinal fluid (CSF). +4 more findings
Full summary, score breakdown and related studies → Original source
-
2019-10-07
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
70/100 ✓ Peer-reviewed Getting a diagnosis Nature neuroscience
Key finding: Significant associations were identified between circRNA expression and AD diagnosis, clinical dementia severity and neuropathological severity. +2 more findings
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →